Dual Oxidases

NADPH oxidases that contain two additional EF HAND MOTIFS and an N-terminal PEROXIDASE domain. They are expressed by THYROCYTES and EPITHELIAL CELLS of the kidney, liver, trachea, lung, and glandular tissues such as the testis, pancreas, and prostate. They are critical for the activity of THYROID PEROXIDASE and play a role in the production of thyroid hormones; they may also have antimicrobial activity through the generation of REACTIVE OXYGEN SPECIES.

Also Known As:

DUOX1; DUOX2; Dual Oxidase 1; Dual Oxidase 2; Duox Proteins; NADPH Thyroid Oxidase 2; Thyroid Oxidase 2; Oxidase 1, Dual; Oxidase 2, Dual; Oxidase 2, Thyroid; Oxidase, Dual; Oxidases, Dual; Proteins, Duox; Dual Oxidase

Networked: 298 relevant articles (4 outcomes, 41 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Doroshow, James H: 13 articles (11/2019 - 06/2009)
2.	van der Vliet, Albert: 12 articles (01/2022 - 02/2007)
3.	Grasberger, Helmut: 12 articles (01/2021 - 07/2006)
4.	Hristova, Milena: 10 articles (01/2021 - 02/2007)
5.	Habibovic, Aida: 9 articles (01/2022 - 03/2013)
6.	Dupuy, Corinne: 9 articles (01/2021 - 04/2007)
7.	Knaus, Ulla G: 8 articles (01/2021 - 02/2008)
8.	Juhasz, Agnes: 8 articles (11/2019 - 06/2009)
9.	Meitzler, Jennifer L: 8 articles (11/2019 - 08/2011)
10.	Roy, Krishnendu: 8 articles (11/2019 - 06/2009)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2017 - "Iodonium analogs with anticancer activity, including the first generation of targeted agents with improved specificity against DUOX2, may provide a novel therapeutic approach to NOX-driven tumors." 11/01/2021 - "It was found that the expression levels of DUOX2 in metastatic sites were significantly higher than those in primary tumor tissues, and this was demonstrated to be associated with poor prognosis. " 11/01/2021 - "Mounting evidence suggests that DUOX2 plays a crucial role in the occurrence and development of cancers. " 01/01/2021 - "Although DUOX1 is normally prominently expressed in epithelial lineages, it is frequently silenced in epithelial-derived cancers by epigenetic mechanisms. " 01/01/2021 - "DUOX2 has been reported to highly express in several types of cancers. "
2.	Infections 10/01/2009 - "Moreover, simultaneous overexpression of NOD2 and DUOX2 was found to result in cooperative protection against bacterial cytoinvasion using the Listeria monocytogenes infection model. " 01/01/2023 - "Duox1 did not affect lung histology assessed at days 0, 30, and 90 post-Mtb infection. " 01/01/2023 - "Mtb titers in the lung, spleen and liver were not different 30 days after infection between WT and Duox1 KO mice. " 01/01/2018 - "Such in vitro and in vivo temporal behaviors of the endogenous H2O2 generation showed a good correlation with those of Duox2 expression after infection. " 01/01/2018 - "We studied the contribution of Duox2 in mucosal host defense against influenza A virus (IAV) infection in in vivo lung. "
3.	Fibrosis (Cirrhosis) 01/01/2021 - "DUOX1 was silenced or overexpressed to investigate its role in fibrosis. " 01/01/2021 - "However, the role of dual oxidase 1 (DUOX1)-induced ROS production and pyroptosis in cardiac fibrosis remains largely unknown. " 01/01/2021 - "NADPH oxidase DUOX1 sustains TGF-β1 signalling and promotes lung fibrosis." 11/01/2018 - "Metformin Protects Against Radiation-Induced Pneumonitis and Fibrosis and Attenuates Upregulation of Dual Oxidase Genes Expression." 01/01/2021 - "The knockdown of DUOX1 protected cardiomyocytes against activin A-induced fibrosis via the inhibition of ROS, cytokine release, and pyroptosis."
4.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/01/2016 - "Reactive oxygen species generated by invading and resident central nervous system (CNS) macrophages have been implicated in mediating demyelination and axonal damage, but demyelination and neurodegeneration proceed even in the absence of obvious immune cell infiltration, during clinical recovery in chronic MS. Here, we employ intravital NAD(P)H fluorescence lifetime imaging to detect functional NADPH oxidases (NOX1-4, DUOX1, 2) and, thus, to identify the cellular source of oxidative stress in the CNS of mice affected by experimental autoimmune encephalomyelitis (EAE) in the remission phase of the disease. "
5.	Demyelinating Diseases (Demyelinating Disease) 01/01/2016 - "Reactive oxygen species generated by invading and resident central nervous system (CNS) macrophages have been implicated in mediating demyelination and axonal damage, but demyelination and neurodegeneration proceed even in the absence of obvious immune cell infiltration, during clinical recovery in chronic MS. Here, we employ intravital NAD(P)H fluorescence lifetime imaging to detect functional NADPH oxidases (NOX1-4, DUOX1, 2) and, thus, to identify the cellular source of oxidative stress in the CNS of mice affected by experimental autoimmune encephalomyelitis (EAE) in the remission phase of the disease. "

Related Drugs and Biologics

1.	NADPH Oxidases (NAD(P)H oxidase)
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Messenger RNA (mRNA)
4.	NAD (NADH)
5.	Metformin (Glucophage)
6.	Liraglutide
7.	nephrin
8.	Dual Oxidases
9.	Iodides
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Hepatectomy
4.	Aftercare (After-Treatment)
5.	Proctectomy