AAA Proteins

A large, highly conserved and functionally diverse superfamily of NTPases and nucleotide-binding proteins that are characterized by a conserved 200 to 250 amino acid nucleotide-binding and catalytic domain, the AAA+ module. They assemble into hexameric ring complexes that function in the energy-dependent remodeling of macromolecules. Members include ATPASES ASSOCIATED WITH DIVERSE CELLULAR ACTIVITIES.

Also Known As:

Networked: 25 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Buck, Martin: 3 articles (05/2010 - 03/2004)
2.	Breakefield, Xandra O: 2 articles (09/2014 - 04/2007)
3.	Ogura, Teru: 2 articles (02/2010 - 05/2004)
4.	Bordes, Patricia: 2 articles (05/2004 - 03/2004)
5.	Zhang, Xiaodong: 2 articles (05/2004 - 03/2004)
6.	Fong, Loren G: 1 article (01/2019)
7.	Gill, Navjot Kaur: 1 article (01/2019)
8.	Kapoor, Tarun M: 1 article (01/2019)
9.	Kim, Paul H: 1 article (01/2019)
10.	Luxton, G W Gant: 1 article (01/2019)

Related Diseases

1.	Dystonia musculorum deformans type 1 04/24/2007 - "TorsinA is an AAA(+) protein located predominantly in the lumen of the endoplasmic reticulum (ER) and nuclear envelope responsible for early onset torsion dystonia (DYT1). " 03/17/2004 - "TorsinA is an "AAA" protein thought to reside in the endoplasmic reticulum (ER), yet both its cellular function and the basis for neuronal dysfunction in DYT1 remain unknown. " 05/22/2000 - "Recent cloning of the gene responsible for this disease, TOR1A (DYT1), identified the encoded protein, torsinA, as a member of the AAA+ superfamily of chaperone proteins and revealed highest levels of expression in dopaminergic neurons in human brain. " 02/01/2009 - "The TOR1A (also named DYT1) gene encodes a protein, TorsinA, a member of the AAA+ superfamily of ATPases. " 01/01/2019 - "DYT1 dystonia is a neurological movement disorder that is caused by a loss-of-function mutation in the DYT1/TOR1A gene, which encodes torsinA, a conserved luminal ATPases-associated with various cellular activities (AAA+) protein. "
2.	Neoplasms (Cancer) 01/01/2018 - "As a member of the AAA+ superfamily, Pontin becomes highly expressed in several malignant tumors, which contributes to tumor progression and influences tumor prognosis. " 02/09/2007 - "TIP48 and TIP49 are two related and highly conserved eukaryotic AAA(+) proteins with an essential biological function and a critical role in major pathways that are closely linked to cancer. " 01/01/2023 - "Obg-like ATPase 1 (OLA1) is a member of the Obg family of P-loop NTPases and has recently been detected in several human cancer cells. " 01/01/2019 - "Dysregulation of AAA proteins has been linked to several diseases, including cancer, suggesting a possible therapeutic role for inhibitors of these enzymes. "
3.	Shock 03/15/2004 - "The Escherichia coli transcription activator PspF (phage shock protein F) is a member of the sigma54-dependent transcriptional activators that belong to the AAA protein family. " 05/14/2004 - "Using the phage shock protein F (PspF) EBP, we identify P-loop residues responsible for nucleotide binding and hydrolysis, consistent with their roles in other P-loop NTPases. " 05/14/2010 - "For one type of member AAA(+) protein (phage shock protein F, PspF), we identified and established the functional significance of strategically placed arginine and glutamate residues that form interacting pairs in response to nucleotide binding. "
4.	Frontotemporal Dementia (Semantic Dementia) 08/01/2012 - "Missense mutations that occur at the interface between two functional domains in the AAA protein p97 lead to suboptimal performance in its enzymatic activity and impaired intracellular functions, causing human disorders such as inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia (IBMPFD). " 02/01/2010 - "Cdc48p/p97 is a highly conserved essential AAA protein that is required for many cellular processes, and is identified as a causative gene for an autosomal dominant human disorder, inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia (IBMPFD). "
5.	Muscular Diseases (Myopathy) 08/01/2012 - "Missense mutations that occur at the interface between two functional domains in the AAA protein p97 lead to suboptimal performance in its enzymatic activity and impaired intracellular functions, causing human disorders such as inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia (IBMPFD). " 02/01/2010 - "Cdc48p/p97 is a highly conserved essential AAA protein that is required for many cellular processes, and is identified as a causative gene for an autosomal dominant human disorder, inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia (IBMPFD). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Adenosine Triphosphatases (ATPase)
3.	Spastin
4.	Glutamic Acid (Glutamate)
5.	Nucleotides
6.	beta Catenin
7.	Small Nucleolar Ribonucleoproteins
8.	Telomerase (Telomerase Reverse Transcriptase)
9.	Phenobarbital (Luminal)
10.	Enzymes