Carbonyl Reductase (NADPH)

NADPH-dependent reductase that catalyzes the reduction of many carbonyl compounds including QUINONES; PROSTAGLANDINS; and XENOBIOTICS.

Also Known As:

13,14-dihydroprostaglandin F2 alpha Synthetase; 13,14-dihydroprostaglandin F2alpha Synthetase; Carbonyl Reductase 1; Daunorubicin Reductase; Isatin Reductase; Monomeric Short-Chain Dehydrogenase-Reductase; NADPH-Carbonyl Reductase; NADPH-dependent Carbonyl Reductase; Ovarian Carbonyl Reductase; 13,14 dihydroprostaglandin F2 alpha Synthetase; 13,14 dihydroprostaglandin F2alpha Synthetase; Carbonyl Reductase, NADPH-dependent; Carbonyl Reductase, Ovarian; Dehydrogenase-Reductase, Monomeric Short-Chain; Monomeric Short Chain Dehydrogenase Reductase; NADPH Carbonyl Reductase; NADPH dependent Carbonyl Reductase; Reductase, Daunorubicin; Reductase, Isatin; Reductase, NADPH-Carbonyl; Reductase, NADPH-dependent Carbonyl; Reductase, Ovarian Carbonyl; Short-Chain Dehydrogenase-Reductase, Monomeric; Synthetase, 13,14-dihydroprostaglandin F2alpha

Networked: 45 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        Carbonyl Reductase (NADPH): 45
        C elegans dhrs-4 protein
        human DHRS2 protein

Experts

1.	Miura, Takeshi: 5 articles (09/2019 - 02/2013)
2.	Kim, Sung Soo: 4 articles (10/2018 - 02/2011)
3.	Nishinaka, Toru: 4 articles (11/2017 - 02/2013)
4.	Terada, Tomoyuki: 4 articles (11/2017 - 02/2013)
5.	Blanco, Javier G: 4 articles (01/2016 - 06/2007)
6.	Yokoyama, Yoshihito: 3 articles (10/2019 - 03/2015)
7.	Ha, Joohun: 3 articles (10/2017 - 02/2011)
8.	Shokat, Kevan M: 3 articles (10/2017 - 02/2011)
9.	Beck, Katharina R: 2 articles (01/2021 - 01/2017)
10.	Homer, Natalie Z M: 2 articles (01/2021 - 01/2017)

Related Diseases

1.	Cardiotoxicity 12/01/2022 - "Aidi injection reduces doxorubicin-induced cardiotoxicity by inhibiting carbonyl reductase 1 expression." 04/27/2012 - "Synthesis of anthracycline alcohol metabolites by carbonyl reductase 1 (CBR1) is crucial for the pathogenesis of cardiotoxicity. " 12/01/2010 - "The pathogenesis of anthracycline-related cardiotoxicity has been linked to the intracardiac synthesis of alcohol metabolites by carbonyl reductase 1 (CBR1). " 10/15/2003 - "Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1." 11/17/2017 - "Chronic cardiotoxicity has been known as a critical adverse effect of doxorubicin and is attributed to its metabolite doxorubicinol produced by carbonyl reductase 1 (CBR1, SDR21C1). "
2.	Hepatocellular Carcinoma (Hepatoma) 02/01/2011 - "Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells." 08/01/2010 - "Carbonyl reductase 1 as a novel target of (-)-epigallocatechin gallate against hepatocellular carcinoma." 10/28/2020 - "The epigallocatechin gallate derivative Y6 reduces the cardiotoxicity and enhances the efficacy of daunorubicin against human hepatocellular carcinoma by inhibiting carbonyl reductase 1 expression."
3.	Breast Neoplasms (Breast Cancer) 10/01/2017 - "Inhibition of Carbonyl Reductase 1 Safely Improves the Efficacy of Doxorubicin in Breast Cancer Treatment." 12/01/2014 - "Gene expression of 13 aldo-keto reductases (AKRs), carbonyl reductase 1, and 10 cytochromes P450 (CYPs) was assessed using quantitative real-time polymerase chain reaction in tumors and paired adjacent nonneoplastic tissues from 68 posttreatment breast carcinoma patients. " 08/01/2023 - "In pooled human placenta, the following xenobiotic and steroid disposition proteins were detected (highest to lowest), 1) enzymes: glutathione S-transferase P, carbonyl reductase 1, aldo-keto reductase 1B1, hydroxysteroid dehydrogenases (HSD3B1 and HSD11B1), aromatase, epoxide hydrolase 1 (EPHX1) and steryl-sulfatase, and 2) transporters: monocarboxylate transporters (MCT1 and 4), organic anion transporting polypeptide 2B1, organic anion transporter 4, and breast cancer resistance protein (BCRP). "
4.	Leukemia 01/01/1979 - "Daunorubicin reductase activity was estimated in peripheral leukocytes drawn from 23 patients with acute or chronic leukemia. " 01/01/1979 - "Daunorubicin reductase activity in leukemia leukocyte homogenates." 09/15/2018 - "Correction: Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide." 08/15/2012 - "Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide." 09/01/1987 - "Characterization of daunorubicin resistance in K562 leukemia cells lacking daunorubicin reductase activity."
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/01/2012 - "Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia." 12/01/1972 - "High-dose daunorubicin therapy for acute nonlymphocytic leukemia: correlation of response and toxicity with pharmacokinetics and intracellular daunorubicin reductase activity." 12/01/2012 - "The present study aimed to investigate the role of expression of daunorubicin-metabolizing enzymes carbonyl reductase 1 and 3 (CBR1 and CBR3) on the in vitro cytotoxicity of daunorubicin in primary acute myeloid leukemia (AML) cells and the effect of genetic variants in CBR1 and CBR3 on the plasma pharmacokinetics of daunorubicin and daunorubicinol (DOL) in AML patients. "

Related Drugs and Biologics

1.	Daunorubicin (Cerubidine)
2.	Doxorubicin (Adriamycin)
3.	epigallocatechin gallate (epigallocatechin-3-gallate)
4.	Anthracyclines
5.	Oxidoreductases (Dehydrogenase)
6.	Enzymes
7.	Proteins (Proteins, Gene)
8.	daunorubicinol
9.	NADP (NADPH)
10.	Arsenic Trioxide (Trisenox)

Related Therapies and Procedures

1.	Liver Transplantation
2.	Therapeutics
3.	Radiotherapy