Peroxisomal Targeting Signals

Protein sorting signals that target proteins to PEROXISOMES.

Also Known As:

PTS1 Peptide; PTS2 Peptide; Peroxisomal Targeting Signal 1; Peroxisomal Targeting Signal 2; Peroxisome Targeting Signal 1; Peroxisome Targeting Signal 2; Peroxisome Targeting Signals; PTS1 Peptides; PTS2 Peptides; Peptide, PTS1; Peptide, PTS2; Peptides, PTS1; Peptides, PTS2; Peroxisomal Targeting Signal; Peroxisome Targeting Signal; Signal, Peroxisomal Targeting; Signal, Peroxisome Targeting; Signals, Peroxisomal Targeting; Signals, Peroxisome Targeting; Targeting Signal, Peroxisomal; Targeting Signal, Peroxisome; Targeting Signals, Peroxisomal; Targeting Signals, Peroxisome

Networked: 17 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Boisvert, François-Michel: 1 article (01/2022)
2.	Bolt, Alicia: 1 article (01/2022)
3.	Braverman, Nancy: 1 article (01/2022)
4.	Dahabieh, Michael S: 1 article (01/2022)
5.	Del Rincón, Sonia V: 1 article (01/2022)
6.	Di Pietro, Erminia: 1 article (01/2022)
7.	Flores González, Raúl Ernesto: 1 article (01/2022)
8.	Goncalves, Christophe: 1 article (01/2022)
9.	Heath, John: 1 article (01/2022)
10.	Huang, Fan: 1 article (01/2022)

Related Diseases

1.	Zellweger Syndrome (Zellweger's Syndrome) 01/01/2021 - "Mutations in PEX5, encoding the peroxisomal targeting signal 1 receptor, can cause peroxisomal biogenesis disorders of the Zellweger spectrum. " 05/18/2007 - "Three mutations in the gene encoding Pex5p, the peroxisomal targeting signal type-1 (PTS1) receptor, have been reported, each associated with a disorder of the Zellweger spectrum of different severity. " 05/01/1993 - "The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein import deficiencies of Zellweger syndrome cells--the PAS8 protein binds to the COOH-terminal tripeptide peroxisomal targeting signal, and is a member of the TPR protein family." 01/01/2023 - "Zellweger spectrum disorders (ZSD) are rare autosomal recessive disorders caused by defects in peroxisome biogenesis factor (PEX; peroxin) genes leading to impaired transport of peroxisomal proteins with peroxisomal targeting signals (PTS). " 01/01/2000 - "In both cases, the enzyme appears to be synthesized as a precursor protein with a N-terminal cleavable presequence containing a peroxisomal targeting signal (PTS) type 2. Levels of the enzyme protein were found to be strongly reduced in human fibroblasts derived from Zellweger syndrome and rhizomelic chondrodysplasia punctata patients. "
2.	Peroxisomal Disorders (Peroxisomal Disorder) 09/01/1999 - "One of the milder clinical variants within the PBDs is neonatal adrenoleukodystrophy (NALD), a disease that is usually associated with partial defects in the import of peroxisomal matrix proteins that carry the type 1 or type 2 peroxisomal targeting signals. " 05/01/1999 - "In a particular neonatal adrenoleukodystrophy cell line, characterized by the absence of a functional peroxisomal targeting signal 1 receptor, the precursor form of the enzyme was detected in Western blots at levels comparable to that of the mature enzyme in control fibroblasts. " 04/24/1998 - "In a neonatal adrenoleukodystrophy patient with an isolated import deficiency of proteins carrying the peroxisomal targeting signal type 1, the precursor form of alkyl-dihydroxyacetonephosphate synthase was detected at a level comparable to that of the mature form in control fibroblasts, in line with an intraperoxisomal localization. " 02/01/2003 - "This region includes the PEX7 gene, which codes for the peroxin 7 receptor protein required for peroxisomal import of proteins containing a peroxisomal targeting signal type 2. Mutations in PEX7 normally cause rhizomelic chondrodysplasia punctata type 1, a severe peroxisomal disorder. "
3.	Rhizomelic Chondrodysplasia Punctata 01/01/1999 - "Mutations in the PEX7 gene encoding a peroxisome targeting signal 2 (PTS2) were identified in two patients with rhizomelic chondrodysplasia punctata (RCDP). " 11/01/1999 - "Remarkably, dihydroxyacetonephosphate acyltransferase activity was strongly reduced to a level comparable to the activities measured in fibroblasts from patients affected by the classical form of rhizomelic chondrodysplasia punctata (caused by a defect in peroxisomal targeting signal type 2 import). " 11/01/1999 - "This interpretation implies that the deficiency of dihydroxyacetonephosphate acyltransferase (targeted by a peroxisomal targeting signal type 1) in the classic form of rhizomelic chondrodysplasia punctata is a consequence of the absence of the alkyl-dihydroxyacetonephosphate synthase protein (targeted by a peroxisomal targeting signal type 2)." 01/01/2000 - "In both cases, the enzyme appears to be synthesized as a precursor protein with a N-terminal cleavable presequence containing a peroxisomal targeting signal (PTS) type 2. Levels of the enzyme protein were found to be strongly reduced in human fibroblasts derived from Zellweger syndrome and rhizomelic chondrodysplasia punctata patients. "
4.	Peroxisome biogenesis disorders 08/01/1998 - "Mutations in the peroxisome targeting signal (PTS) 1 receptor gene, PEX5 , are responsible for complementation group (CG) 2 of the peroxisome biogenesis disorders (PBD). " 08/27/1999 - "To investigate mechanisms related to functions of the peroxisome targeting signal (PTS) 1 receptor, Pex5p, we analyzed peroxisome matrix protein import in fibroblasts from three patients with peroxisome biogenesis disorders, all with different mutations in the PEX5 gene. " 01/01/2022 - ": ABCD3/PMP70: ATP binding cassette subfamily D member 3; ACOX1: acyl-CoA oxidase 1; AP: autophagosome; COX: cytochrome c oxidase; CQ: chloroquine; CRISPRi: clustered regularly interspaced short palindromic repeats interference; DLBCL: diffuse large B-cell lymphoma; GO: gene ontology; dCas9: Cas9 endonuclease dead, or dead Cas9; HDACi: histone deacetylase inhibitors; IHC: Immunohistochemistry; LAMP2: lysosomal associated membrane protein 2; LCFAs: long-chain fatty acids; LFQ-MS: label-free quantitation mass spectrometry; LPC: lysophoshatidylcholine; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MTOR: mechanistic target of rapamycin kinase; PBD: peroxisome biogenesis disorders; PTS1: peroxisomal targeting signal 1; ROS: reactive oxygen species; sgRNA: single guide RNA; VLCFAs: very-long chain fatty acids; Vor: vorinostat; WO: wash-off."
5.	Overactive Urinary Bladder (Overactive Bladder) 02/01/2018 - "Propiverine, a frequently-prescribed pharmaceutical for the treatment of symptoms associated with overactive bladder syndrome, provoked massive intranuclear and cytosolic protein inclusions in rat proximal tubule epithelium, primarily consisting of the peroxisomal targeting signal 1 (PTS1) containing protein d-amino acid oxidase (DAAO). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Enzymes
3.	Histone Deacetylase Inhibitors
4.	Lysosomal-Associated Membrane Protein 2
5.	Acyl-CoA Oxidase
6.	Sirolimus (Rapamycin)
7.	Complementary DNA (cDNA)
8.	Reactive Oxygen Species (Oxygen Radicals)
9.	Phytanic Acid
10.	Phosphotransferases (Kinase)