Endothelial Protein C Receptor

A glycosylated transmembrane receptor for PROTEIN C that is highly expressed by endothelial cells on the surface of large blood vessels in the heart and lungs. It facilitates protein C activation by the THROMBIN and THROMBOMODULIN complex in blood coagulation.

Also Known As:

Networked: 405 relevant articles (16 outcomes, 65 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Esmon, Charles T: 28 articles (12/2021 - 07/2002)
2.	Lavstsen, Thomas: 21 articles (01/2021 - 06/2013)
3.	Turner, Louise: 14 articles (01/2021 - 06/2013)
4.	Bae, Jong-Sup: 14 articles (04/2015 - 03/2007)
5.	Ruf, Wolfram: 13 articles (01/2022 - 06/2002)
6.	Theander, Thor G: 13 articles (03/2020 - 06/2013)
7.	Griffin, John H: 11 articles (01/2022 - 03/2003)
8.	Esmon, C T: 11 articles (11/2014 - 03/2000)
9.	Ku, Sae-Kwang: 10 articles (04/2015 - 09/2013)
10.	Smith, Joseph D: 9 articles (01/2022 - 06/2013)

Related Diseases

1.	Sepsis (Septicemia) 02/01/2022 - "In general, ISO suppressed sepsis-induced ALI in mice by activating an EPCR-dependent JAK2/STAT3 pathway." 11/12/2018 - "Under pathophysiological conditions like sepsis, the interactions between EPCR and PC become impaired. " 03/01/2018 - "Using the preceding and current sepsis definitions, sEPCR levels and the H3 haplotype were not associated with sepsis severity and the risk of poor outcomes in septic patients; however, the EPCR H3 allele contributed to higher levels of sEPCR." 04/01/2017 - "Conclusions EPCR polymorphisms may be associated with increased risk of sepsis, but this has no effect on the release of sEPCR in patients with sepsis." 04/01/2017 - "Plasma sEPCR levels of sepsis patients were higher than controls and showed no correlation with EPCR gene polymorphisms. "
2.	Malaria 12/01/2015 - "It has been hypothesized that elevated sEPCR levels, possibly linked to the PROCR H3 genetic variant, may confer protection against severe forms of malaria. " 12/01/2015 - "The PROCR H3 allele was associated with higher levels of sEPCR, confirming earlier findings, however, in this Tanzanian population; neither PROCR haplotype nor level of sEPCR was associated with severe malaria, however, larger studies are needed to confirm these findings." 12/01/2015 - "This study determined the frequencies of PROCR haplotypes H1-4 and plasma levels of sEPCR in a Tanzanian study population to investigate a possible association with severe malaria. " 03/17/2014 - "In this study, the association of PROCR rs867186 with severe malaria is examined in Thai population. " 01/01/2014 - "Here we present the first analysis of genetic variation in the PROCR gene in the context of severe malaria in African subjects and show that genetic variation in the PROCR gene in our study population does not influence susceptibility to major severe malaria phenotypes."
3.	Inflammation (Inflammations) 04/01/2013 - "This study demonstrates an important protective role for EPCR in vivo against vascular leakage during inflammation and suggests that EPCR-dependent vascular protection is organ-specific." 11/21/2023 - ": Abca1, Casp1, Lpl, Procr, and Tnfrsf1a may promote the pathogenesis of ischemic or hypoxic SCI by regulating vascular damage, inflammation, and immune infiltration." 10/20/2023 - "Importantly, inflammation-dependent EPCR expression on tissue-resident macrophages was also observed in vivo. " 08/01/2013 - "Because of the pleiotropic nature of EPCR and TM, these data implicate disruption of the endothelial protective properties at vulnerable sites and particularly in the brain, linking coagulation and inflammation with IE sequestration. " 05/01/2012 - "However, the discovery of the cytoprotective, anti-inflammatory and anti-apoptotic features of the activated PC (APC) and the required involvement of EPCR for APC to exert such actions did place the receptor in a privileged position in the crosstalk between coagulation and inflammation. "
4.	Hemophilia A (Haemophilia) 08/14/2014 - "Here, we study whether EPCR facilitates rhFVIIa hemostasis in hemophilia using a mouse model system. " 05/01/2014 - "Wild-type, EPCR-deficient, EPCR-overexpressing and hemophilia A mice were used in the studies. " 01/01/2020 - "The present data indicate that EPCR could be an attractive new target to prevent joint damage in hemophilia patients." 01/01/2020 - "For this, we first generated hemophilia A (FVIII-/-) mice lacking EPCR (EPCR-/-FVIII-/-) or overexpressing EPCR (EPCR++ FVIII-/-). " 01/01/2017 - "These data implied a role of EPCR in the action of hFVIIa in hemophilia treatment. "
5.	Cerebral Malaria 11/17/2020 - "EPCR binding is a major determinant of cerebral malaria whereas the ICAM-1-binding role is still questioned. " 01/11/2016 - "Erratum to: Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding." 12/08/2015 - "Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding." 12/01/2015 - "These data reveal a previously unknown functional heterogeneity in the interaction between P. falciparum and EPCR and have major implications for understanding the distinct clinical pathologies of cerebral malaria and developing new treatment strategies. " 05/01/2015 - "High plasma levels of soluble endothelial protein C receptor are associated with increased mortality among children with cerebral malaria in Benin."

Related Drugs and Biologics

1.	Endothelial Protein C Receptor
2.	Thrombin
3.	activated protein C receptor
4.	Factor VII (Proconvertin)
5.	Heme Oxygenase-1
6.	Messenger RNA (mRNA)
7.	PAR-1 Receptor
8.	HMGB1 Protein (HMG1)
9.	Heterophile Antigens
10.	HLA Antigens (Human Leukocyte Antigens)

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Renal Dialysis (Hemodialysis)
4.	Rewarming
5.	Punctures