ATPases Associated with Diverse Cellular Activities

A large highly conserved family of ATPases with diverse functions in cells that are characterized by the presence of a P-LOOP and a ring shape. They couple the energy generated by ATP hydrolysis to remodeling or mechanical translocation of their target molecules.

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Networked: 163 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Houry, Walid A: 4 articles (01/2020 - 04/2016)
2.	Chou, Tsui-Fen: 3 articles (01/2022 - 07/2014)
3.	Zolkiewski, Michal: 3 articles (05/2021 - 01/2014)
4.	Deshaies, Raymond J: 3 articles (03/2021 - 07/2014)
5.	Anderson, Daniel J: 3 articles (01/2021 - 11/2015)
6.	Le Moigne, Ronan: 3 articles (01/2021 - 11/2015)
7.	Zhou, Han-Jie: 3 articles (01/2021 - 11/2015)
8.	Langer, Thomas: 3 articles (11/2019 - 10/2005)
9.	Lander, Gabriel C: 3 articles (01/2019 - 10/2018)
10.	Roll-Mecak, Antonina: 3 articles (01/2019 - 04/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Here, we report that the expression of RuvB like AAA ATPase 1 (RUVBL1) is upregulated in ENZR cells and xenograft models and prostate tumors in patients. " 01/07/2020 - "High level of the multifunctional AAA-ATPase p97/VCP is often correlated to the development of cancer; however, the underlying mechanism is not understood completely. " 01/01/2020 - "TRIP13, encoding an AAA-ATPase, is a key component of the spindle assembly checkpoint, and recurrent homozygous nonsense variants and a splicing variant in TRIP13 are reported to cause Wilms tumors in children. " 01/01/2020 - "VCP/p97, an AAA-ATPase, is reported to be overexpressed in many types of cancers. " 01/01/2020 - "RUVBL1 and RUVBL2 (collectively RUVBL1/2) are essential AAA+ ATPases that function as co-chaperones and have been implicated in cancer. "
2.	Carcinogenesis 01/01/2015 - "Recent studies have implicated the AAA+ ATPase pontin in many cellular activities that are highly relevant to carcinogenesis. " 09/01/2008 - "Studies in model organisms or cultured human cells suggest potential implications in carcinogenesis for the AAA+ ATPases Pontin and Reptin. " 07/01/2013 - "The AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis." 10/01/2020 - "The AAA+ ATPase and bromodomain factor ATAD2/ANCCA is overexpressed in many types of cancer, but how it contributes to tumorigenesis is not understood. " 01/01/2020 - "RUVBL1 and RUVBL2 are highly conserved ATPases that belong to the AAA+ (ATPases Associated with various cellular Activities) superfamily and are involved in various complexes and cellular processes, several of which are closely linked to oncogenesis. "
3.	AIDS-Related Complex (ARC) 04/01/2004 - "Deletion mutants of the Rhodococcus erythropolis ARC AAA ATPase were generated and characterized by biochemical analysis and electron microscopy. " 03/20/1998 - "Characterization of ARC, a divergent member of the AAA ATPase family from Rhodococcus erythropolis." 01/01/2015 - "Phylogenetic classification made by CLANS, positioned this sequence into the ARC divergent branch of the AAA ATPase family of proteins. " 04/30/2010 - "The structure of the CED-4 apoptosome reveals shared principles for the NB-ARC family of AAA(+) ATPases and suggests a mechanism for the activation of CED-3." 04/01/2004 - "The N-terminal domain of related AAA ATPases mediates the interaction with substrates or co-factors, suggesting a regulatory function for the N-terminal coiled coil of the ARC ATPase. "
4.	Hepatocellular Carcinoma (Hepatoma) 12/01/2018 - "The AAA+ ATPase Reptin is overexpressed in hepatocellular carcinoma and preclinical studies indicate that it could be a relevant therapeutic target. " 01/01/2020 - "RuvBL1 is an AAA+ ATPase whose expression in hepatocellular carcinoma (HCC) correlates with a poor prognosis. "
5.	Endometrial Neoplasms (Endometrial Cancer) 06/01/2015 - "This study aimed to explore the clinical significance of AAA+ (ATPases associated with various cellular activities) nuclear coregulator cancer-associated (ANCCA) protein expression in endometrial carcinoma (EC). "

Related Drugs and Biologics

1.	Proteasome Endopeptidase Complex (Proteasome)
2.	Ubiquitin
3.	Ubiquitin-Activating Enzymes (Ubiquitin-Activating Enzyme)
4.	Proteins (Proteins, Gene)
5.	Proteome
6.	Valosin Containing Protein
7.	Adenosine Triphosphatases (ATPase)
8.	Spastin
9.	Glutamic Acid (Glutamate)
10.	Adenosine Triphosphate (ATP)

Related Therapies and Procedures

1.	Therapeutics