Sodium-Hydrogen Exchanger 1

A sodium-hydrogen antiporter expressed by many cell types, especially on the basolateral surfaces of EPITHELIAL CELLS. It functions through an inward sodium ion chemical gradient to eliminate acids (protons) generated by metabolism and regulate intracellular pH. It is highly sensitive to AMILORIDE.

Also Known As:

Networked: 51 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Karmazyn, Morris: 4 articles (12/2014 - 10/2006)
2.	Yang, Xuekang: 4 articles (12/2013 - 09/2010)
3.	Rajapurohitam, Venkatesh: 3 articles (12/2014 - 01/2011)
4.	Dong, Wei: 3 articles (03/2011 - 09/2010)
5.	Dou, Kefeng: 3 articles (03/2011 - 09/2010)
6.	Song, Zhenshun: 3 articles (03/2011 - 09/2010)
7.	Wang, Desheng: 3 articles (03/2011 - 09/2010)
8.	Li, Peng: 2 articles (01/2019 - 01/2016)
9.	Kilić, Ana: 2 articles (12/2014 - 01/2011)
10.	Pedersen, Stine F: 2 articles (01/2014 - 01/2014)

Related Diseases

1.	Lactic Acidosis 10/01/2012 - "Selective sodium-hydrogen exchanger 1 (NHE1) inhibitors have been shown to improve haemodynamics and reduce mortality in animal studies of acute lactic acidosis and should also be examined further. " 05/01/2011 - "Potential role of NHE1 (sodium-hydrogen exchanger 1) in the cellular dysfunction of lactic acidosis: implications for treatment." 05/01/2011 - "Recent research suggests that lactic acidosis can be associated with activation of the sodium-hydrogen exchanger 1 (NHE1), potentially giving rise to deleterious increases in cellular sodium and calcium ion concentrations, which can cause cardiac stunning and arrhythmias, extend cerebral damage, and worsen kidney function. "
2.	Weight Gain 03/01/2014 - "Treatment of ob/ob mice with the UII receptor antagonist SB657510 significantly improved glucose levels, blood pressure, hyperlipidemia, expression of myocardial SERCA2a, intracellular Na(+) and Ca(2+) and cardiac function in association with a decrease in weight gain, and mammalian target of rapamycin (mTOR) and sodium/hydrogen exchanger 1 (NHE-1) protein expression compared with vehicle (P<0.05). "
3.	Hyperlipidemias (Hyperlipidemia) 03/01/2014 - "Treatment of ob/ob mice with the UII receptor antagonist SB657510 significantly improved glucose levels, blood pressure, hyperlipidemia, expression of myocardial SERCA2a, intracellular Na(+) and Ca(2+) and cardiac function in association with a decrease in weight gain, and mammalian target of rapamycin (mTOR) and sodium/hydrogen exchanger 1 (NHE-1) protein expression compared with vehicle (P<0.05). "
4.	Leukemia 05/15/2015 - "The aim of this study was to estimate the reversal effects of down-regulation of Na(+)/H(+) exchanger 1 (NHE1) on the chemoresistance of BCR-ABL-positive leukemia patients' cells and cell lines. " 09/01/2011 - "The present study was undertaken to estimate the therapeutic benefit to down-regulate the Na(+)/H(+) exchanger 1 (NHE1) for reversing chemoresistance of BCR-ABL-positive leukemia patient cells and cell lines. "
5.	Diabetic Neuropathies (Diabetic Neuropathy) 08/01/2013 - "The aim of this study was to evaluate whether Na(+)/H(+) exchanger 1 inhibition reverses experimental peripheral diabetic neuropathy. " 08/01/2013 - "In conclusion, these findings support an important role for Na(+)/H(+) exchanger 1 in functional, structural, and biochemical manifestations of peripheral diabetic neuropathy and provide the rationale for development of Na(+)/H(+) exchanger 1 inhibitors for treatment of diabetic vascular and neural complications. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	TOR Serine-Threonine Kinases
3.	Glucose (Dextrose)
4.	SB 657510
5.	Protons (Proton)
6.	Calcineurin
7.	Atrial Natriuretic Factor (ANF)
8.	Amiloride (Midamor)
9.	Adenosine Triphosphatases (ATPase)
10.	cariporide

Related Therapies and Procedures

1.	Radiotherapy