MutS Proteins

DNA repair proteins that include the bacterial MutS DNA mismatch-binding protein and its eukaryotic homologs that function in DNA MISMATCH REPAIR and recombination of DNA during MEIOSIS. MutS has a conserved mismatch recognition domain characterized by GxFxE, or similar AMINO ACID MOTIFS that also occur in eukaryotic homologs such as MSH1, MSH6, and MSH8. All MutS proteins also contain a highly-conserved ATP-binding domain and most have weak ATPase activity.

Also Known As:

Networked: 144 relevant articles (0 outcomes, 21 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Rossi, Benedito Mauro: 3 articles (10/2012 - 07/2002)
2.	Li, Wei: 2 articles (01/2022 - 12/2020)
3.	Dai, Min: 2 articles (12/2021 - 01/2019)
4.	Zhang, Bin: 2 articles (12/2021 - 01/2019)
5.	Abedalthagafi, Malak: 2 articles (06/2021 - 01/2020)
6.	Akamizu, Takashi: 2 articles (04/2020 - 09/2017)
7.	Ariyasu, Hiroyuki: 2 articles (04/2020 - 09/2017)
8.	Doi, Asako: 2 articles (04/2020 - 09/2017)
9.	Furuta, Hiroto: 2 articles (04/2020 - 09/2017)
10.	Inoshita, Naoko: 2 articles (04/2020 - 09/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "Several studies have shown that MutS homolog 2 (MSH2) is highly expressed in many cancer tissues. " 12/01/2022 - "MutS homolog 2 (MSH2) is a mismatch repair gene that plays a critical role in DNA repair pathways, and its mutations are associated with different cancers. " 01/01/2022 - "A Pan-Cancer Analysis on the Systematic Correlation of MutS Homolog 2 (MSH2) to a Malignant Tumor." 12/07/2021 - "An integrative pan-cancer analysis reveals the oncogenic role of mutS homolog 6 (MSH6) in human tumors." 12/01/2020 - "Patients with EMAST-negative tumors were younger; their tumors exhibited well differentiation, less venous invasion, and greater mutS homolog 3 expression. "
2.	Colorectal Neoplasms (Colorectal Cancer) 05/01/2018 - "Analysis of human MutS homolog 2 missense mutations in patients with colorectal cancer." 03/01/1996 - "The recently identified hMSH2 (human MutS homolog 2) gene in colorectal carcinomas possesses sequence homologies to DNA mismatch repair genes in bacteria and yeast. " 12/01/2018 - "Thereafter, to confirm the accuracy of this assay, we examined 317 colorectal cancer (CRC) specimens, comprising of 105 dMMR [45 MutL homolog (MLH)1-deficient, 45 MutS protein homolog (MSH)2-deficient, and 15 MSH6-deficient tumors] and 212 MMR-proficient (pMMR) tumors as a test set. " 01/01/2018 - "mutS homolog 2 (MSH2) deficiency may be involved in the development of microsatellite instability found in certain sporadic colorectal tumors. " 04/01/2012 - "Down-regulation of MutS homolog 3 by hypoxia in human colorectal cancer."
3.	Hereditary Nonpolyposis Colorectal Neoplasms (Hereditary Nonpolyposis Colorectal Cancer) 01/01/2022 - "MutS homolog 2 (MSH2) is a crucial participant in human DNA repair, and lots of the studies functionally associated with it were begun with hereditary nonpolyposis colorectal cancer (HNPCC). " 05/01/2018 - "Germline mutations of DNA mismatch repair gene human MutS homolog 2 (hMSH2) are associated with hereditary nonpolyposis colorectal cancer (HNPCC). " 12/17/1993 - "Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer." 04/01/2017 - "We present a case of an endometrial cancer patient with germline mutation in MutS homolog 6 (MSH6), associated with Lynch syndrome. " 01/25/2001 - "The human mutS homolog gene MSH2 is essential for DNA mismatch repair (MMR) and defects in this gene can result in increased mutagenesis, genomic instability and hereditary nonpolyposis colorectal cancer (HNPCC). "
4.	Breast Neoplasms (Breast Cancer) 12/01/2010 - "In this study, we reported that TGF-β downregulated the mutS homolog 2 (MSH2), a central component of the DNA mismatch repair (MMR) system, in HER2-transformed MCF10A mammary epithelial cells and in breast cancer (BC) cells. " 01/01/2020 - "Novel, deleterious variants in mesotheliomas included MutS homolog 3 (1% [one of 84]; 95% confidence interval [CI]: 0%-7%), breast cancer gene 1-associated ring domain 1 (1% [one of 84]; 95% CI: 0%-7%), and RecQ-like helicase 4 (2% [two of 84]; 95% CI: 0%-9%). " 04/01/2014 - "Family history, clinical characteristics, and IHC data (breast cancer 1, early onset [BRCA1], breast cancer 2, early onset [BRCA2], mutS homolog 2 [MSH2], mutL homolog 1 [MLH1]) were collected for all cases from the patients' medical charts. " 12/01/2010 - "Context-dependent bidirectional regulation of the MutS homolog 2 by transforming growth factor β contributes to chemoresistance in breast cancer cells." 06/07/1999 - "A large deletion of 1476 bp, as well as point mutations in human MutS homolog 2 (hMSH2) cDNA, was revealed in breast carcinomas. "
5.	Carcinoma (Carcinomatosis) 06/01/2013 - "Immunohistochemical tests for mutS homolog 2 showed a lack of expression in both eyelid carcinomas." 06/01/2011 - "Immunohistochemical analysis of the patient's colon carcinoma and his GBM both revealed loss of the mismatch repair proteins mutS homolog 2 (MSH2) and mutS homolog 6 (MSH6)." 02/01/2006 - "Mutation of human mutL homolog 1 (MLH-1) and human mutS homolog 2 (MSH-2) has been linked with the pathogenesis of colorectal carcinoma in hereditary nonpolyposis colorectal cancer syndrome and other carcinomas. " 11/01/2013 - "The aim of this study was to investigate the clinicopathological characteristics of colorectal serrated lesions associated with invasive carcinoma and high-grade intraepithelial neoplasm (HIN), as well as to determine the immunohistochemical expression of MutL homolog 1 (MLH1), MutS homolog 2 (MSH2), K-ras and O6-methylguanine-DNA methyltransferase (MGMT). " 12/01/2020 - "The development and progression of carcinomas are closely associated with DDR pathway aberrations, including the epigenetic silencing of gene O6-alkylguanine-DNA methyltransferase (MGMT); deficiencies of mismatch repair (MMR) genes, including MutL homolog 1 (MLH1), MutS protein homologue (MSH)-2 (MSH2), MSH6, and PMS1 homolog 2; the mismatch repair system component (PMS2); and mutations of homologous recombination repair (HRR) genes, such as the breast cancer susceptibility gene 1/2 (BRCA1/2). "

Related Drugs and Biologics

1.	MutL Protein Homolog 1
2.	Proteins (Proteins, Gene)
3.	Methyltransferases
4.	DNA (Deoxyribonucleic Acid)
5.	Platinum
6.	Alkylating Agents
7.	Long Noncoding RNA
8.	Growth Differentiation Factor 9
9.	O(6)-Methylguanine-DNA Methyltransferase
10.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Adjuvant Chemotherapy
4.	Semiconductors
5.	Electrodes (Electrode)