Member 1 Subfamily D ATP Binding Cassette Transporter

ATP-binding cassette transporter that functions in the import of long chain (13-21 carbons) and very long chain fatty acids (> 22 carbons), or their acyl-CoA-derivatives, into PEROXISOMES. Mutations in the ABCD1 gene are associated with the X-linked form of ADRENOLEUKODYSTROPHY.

Also Known As:

ATP Binding Cassette Transporter, Subfamily D, Member 1; ABCD1 Protein; ABCD1 Transporter; ATP Binding Cassette Transporter, Sub-Family D, Member 1; Adrenoleukodystrophy Protein

Networked: 62 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Pujol, Aurora: 6 articles (01/2022 - 12/2012)
2.	Kemp, Stephan: 5 articles (01/2021 - 03/2010)
3.	Fourcade, Stéphane: 4 articles (01/2022 - 12/2012)
4.	Singh, Jaspreet: 4 articles (01/2022 - 01/2009)
5.	Shimozawa, Nobuyuki: 4 articles (08/2021 - 06/2007)
6.	Singh, Inderjit: 4 articles (01/2017 - 01/2009)
7.	Theodoulou, Frederica L: 4 articles (12/2011 - 01/2009)
8.	Ferrer, Isidre: 3 articles (01/2022 - 12/2012)
9.	Ruiz, Montserrat: 3 articles (01/2022 - 08/2013)
10.	Imanaka, Tsuneo: 3 articles (01/2019 - 06/2007)

Related Diseases

1.	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 01/01/2021 - "The gene mutations of the ATP-binding-cassette transporter subfamily D member 1 (ABCD1) can lead to the inherited neuro-metabolic malfunction disease X-linked adrenoleukodystrophy (X-ALD). " 01/01/2019 - "The stability of each mutant ABCD1-GFP in CHO cells was similar to the corresponding mutant ABCD1 protein in X-ALD fibroblasts. " 01/01/2019 - "Stability of the ABCD1 Protein with a Missense Mutation: A Novel Approach to Finding Therapeutic Compounds for X-Linked Adrenoleukodystrophy." 12/01/2017 - "X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by a mutation in the ATP-binding cassette transporter subfamily D member 1 (ABCD1) gene. " 03/01/2016 - "In adrenoleukodystrophy, the uptake of VLCFAs by peroxisomes is impaired by defects of the ABCD1 transporter. "
2.	Peroxisomal Disorders (Peroxisomal Disorder) 01/01/2017 - "X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by mutations in the ABCD1 gene, leading to a defect in the peroxisomal adrenoleukodystrophy protein (ALDP), which inhibits the β-oxidation of very long chain fatty acids (VLCFAs). " 12/01/2001 - "X-linked adrenoleukodystrophy, representing the other group of peroxisomal disorders, is caused by the lack of the adrenoleukodystrophy protein, with an accumulation of very long chain fatty acids. " 06/28/2013 - "X-linked adrenoleukodystrophy (X-ALD), an inherited peroxisomal disorder, is caused by mutations in the ABCD1 gene encoding the peroxisomal ATP-binding cassette (ABC) transporter ABCD1 (adrenoleukodystrophy protein, ALDP). " 05/01/1999 - "Inherited defects in the peroxisomal ATP-binding cassette (ABC) transporter adrenoleukodystrophy protein (ALDP) lead to the lethal peroxisomal disorder X-linked adrenoleukodystrophy (X-ALD), for which no efficient treatment has been established so far. " 03/27/1998 - "The interaction of the adrenoleukodystrophy protein (ALDP), mutated in the peroxisomal disorder X-linked adrenoleukodystrophy, and the very long-chain acyl-CoA synthetase (VLACS), the enzyme whose function is missing in this disease, remains obscure. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2019 - "Mutations in the ABCD1 gene that encodes peroxisomal ABCD1 protein cause X-linked adrenoleukodystrophy (X-ALD), a rare neurodegenerative disorder. " 04/25/2012 - "X-linked adrenoleukodystrophy (ALD; MIM #300100) is a neurodegenerative disorder caused by mutations in the ABCD1 adrenoleukodystrophy protein gene. " 05/01/2015 - "X-linked Adrenoleukodystrophy (X-ALD), an inherited peroxisomal metabolic neurodegenerative disorder, is caused by mutations/deletions in the ATP-binding cassette transporter (ABCD1) gene encoding peroxisomal ABC transporter adrenoleukodystrophy protein (ALDP). " 01/01/2023 - "X-linked adrenoleukodystrophy (X-ALD; OMIM:300100) is a progressive neurodegenerative disorder caused by a congenital defect in the ATP-binding cassette transporters sub-family D member 1 gene (ABCD1) producing adrenoleukodystrophy protein (ALDP). "
4.	Inborn Genetic Diseases (Disease, Hereditary) 04/14/2022 - "X-linked adrenoleukodystrophy (X-ALD) is a genetic disorder caused by pathogenic variants in the ATP-binding cassette subfamily D member 1 gene (ABCD1) that encodes the adrenoleukodystrophy protein (ALDP). " 08/11/2021 - "Adrenoleukodystrophy (X-ALD) is an X-linked genetic disorder caused by mutation of the ATP-binding cassette subfamily D member 1 gene, which encodes the peroxisomal membrane protein, adrenoleukodystrophy protein (ALDP). "
5.	Coma (Comas) 01/01/2009 - "COMATOSE (CTS), the Arabidopsis homologue of human Adrenoleukodystrophy protein (ALDP), is required for import of substrates for peroxisomal beta-oxidation. " 01/01/2009 - "COMATOSE (CTS), the plant homologue of Adrenoleukodystrophy protein, is a full length ABC transporter localized in peroxisomes. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Amino Acids
3.	Fatty Acids (Saturated Fatty Acids)
4.	Adenosine Triphosphate (ATP)
5.	ATP-Binding Cassette Transporters (ABC Transporters)
6.	Membrane Proteins (Integral Membrane Proteins)
7.	Enzymes
8.	Subfamily D ATP Binding Cassette Transporter
9.	Endocannabinoids
10.	Acyl-CoA Oxidase

Related Therapies and Procedures

1.	Therapeutics