MDS1 and EVI1 Complex Locus Protein

A DNA binding protein, transcriptional regulator, and proto-oncogene protein that contains 10 CYS2-HIS2 ZINC FINGERS. It functions as a positive or negative regulator of expression for target genes involved in organism development.

Also Known As:

Ecotropic Virus Integration Site 1 Protein Homolog; MECOM Protein; Myelodysplasia Syndrome-Associated Protein 1; Zinc Finger Protein Evi1; Myelodysplasia Syndrome Associated Protein 1

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Sukhanova, Madina: 2 articles (01/2022 - 01/2013)
2.	Altman, Jessica: 1 article (01/2022)
3.	Chen, Qing: 1 article (01/2022)
4.	Chen, Yi-Hua: 1 article (01/2022)
5.	Frankfurt, Olga: 1 article (01/2022)
6.	Gao, Juehua: 1 article (01/2022)
7.	Gurbuxani, Sandeep: 1 article (01/2022)
8.	Jennings, Lawrence: 1 article (01/2022)
9.	Ji, Peng: 1 article (01/2022)
10.	Kocherginsky, Masha: 1 article (01/2022)

Related Diseases

1.	Leukemia 01/01/2013 - "High-density whole-genome SNP array analysis of leukemia cells showed a number of submicroscopic copy number abnormalities, including a deletion of the MECOM (MDS1 and EVI1 complex locus protein EVI1) gene at 3q26. " 12/06/2011 - "The zinc finger protein EVI1 is causally associated with acute myeloid leukemogenesis, and inhibition of its function with a small molecule therapeutic may provide effective therapy for EVI1-expressing leukemias. " 01/01/2020 - "Deregulation of cellular metabolism, leading to development of leukemia, occurs through abnormally high expression of transcription factors such as MYC and Ecotropic Virus Integration site 1 protein homolog (EVI1). "
2.	Neoplasms (Cancer) 01/01/2022 - "Our results demonstrated that myeloid neoplasms with nonclassic 3q26.2/MECOM rearrangements encompass a diverse group of diseases with poor clinical outcome, overexpression of Mecom protein as a result of the nonclassic mechanism of MECOM activation." 01/01/2016 - "MDS1 and EVI1 complex locus protein EVI1 (MECOM) is an oncogenic transcription factor in several kinds of cancers. "
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/01/2012 - "In acute myeloid leukemia (AML), increased ecotropic virus integration site 1 protein homolog (EVI1) gene expression is prognostically unfavorable. "
4.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2019 - "Ecotropic virus integration site 1 protein homolog (EVI1), a well-known oncogenic transcriptional factor of hematopoietic cells, contributes to pancreatic cancer oncogenicity through increased expression of KRAS. "

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)

Related Therapies and Procedures

1.	Therapeutics