Cell-Free Nucleic Acids

Nucleic acids (DNA or RNA) found circulating in SERUM; PLASMA; or other BODY FLUIDS.

Also Known As:

Cell-Free DNA; Cell-Free Deoxyribonucleic Acid; Cell-Free Nucleic Acid; Cell-Free RNA; Cell-Free Ribonucleic Acid; Circulating Cell-Free Nucleic Acids; Circulating DNA; Circulating Nucleic Acids; Circulating RNA; cfDNA; cfRNA; cirDNA; cirRNA; Acid, Cell-Free Deoxyribonucleic; Acid, Cell-Free Ribonucleic; Acid, Circulating Nucleic; Acids, Circulating Nucleic; Cell Free DNA; Cell Free Deoxyribonucleic Acid; Cell Free Nucleic Acid; Cell Free Nucleic Acids; Cell Free RNA; Cell Free Ribonucleic Acid; Circulating Cell Free Nucleic Acid; Circulating Cell Free Nucleic Acids; DNA, Cell-Free; DNA, Circulating; Deoxyribonucleic Acid, Cell-Free; Nucleic Acid, Cell-Free; Nucleic Acid, Circulating; Nucleic Acids, Cell-Free; Nucleic Acids, Circulating; RNA, Cell-Free; RNA, Circulating; Ribonucleic Acid, Cell-Free; Circulating Cell-Free Nucleic Acid; Circulating Nucleic Acid

Networked: 5287 relevant articles (188 outcomes, 843 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleic Acids: 11752
  - Cell-Free Nucleic Acids: 5287
    - Circulating Tumor DNA: 2988
    - Circulating MicroRNA: 467

Experts

1.	Pantel, Klaus: 32 articles (11/2022 - 06/2004)
2.	Lanman, Richard B: 28 articles (01/2022 - 01/2015)
3.	Nicolaides, K H: 26 articles (01/2021 - 01/2013)
4.	Douvdevani, Amos: 24 articles (12/2022 - 11/2009)
5.	Lo, Y M Dennis: 22 articles (10/2022 - 03/2003)
6.	Hoon, Dave S B: 22 articles (01/2022 - 01/2004)
7.	Zhang, Wei: 20 articles (01/2022 - 01/2017)
8.	Schwarzenbach, Heidi: 20 articles (12/2020 - 06/2004)
9.	Martens, John W M: 19 articles (05/2022 - 12/2016)
10.	Mouliere, Florent: 19 articles (01/2022 - 10/2010)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2010 - "Improved detection methods have led to increased knowledge on cell-free DNA, and recent studies showed that most cancer patients have increased levels of cell-free DNA. " 01/01/2022 - "In recent years, due to the development of highly sensitive molecular technologies, cfDNA-based assays are now being introduced into the clinic as the so called "liquid biopsy." The advantages of a liquid biopsy over traditional biopsy and imaging have led to the implementation in the clinic for early cancer detection, improved cancer staging, early detection of relapse, real-time monitoring of therapeutic efficacy, and detection of therapeutic targets and resistance mechanisms. " 01/01/2019 - "Assessment of the tumor-derived cfDNA modifications combined with high-throughput analysis techniques holds promise for developing highly specific noninvasive diagnostic tests. " 01/01/2023 - "Overall, this proof-of-concept study provides a technical platform to utilize multimodal cfDNA features for improved cancer detection." 01/01/2023 - "Next, we performed an ANOVA test on these genes, resulting in the identification of 12 genes that showed statistically significant higher levels of 5hmC in cfDNA and gDNA from cancer patients compared to healthy individuals. "
2.	Breast Neoplasms (Breast Cancer) 03/01/2017 - "In this review, the results of 14 relevant studies, investigating the efficacy of cell-free DNA methylation screening for breast cancer diagnosis, have been summarized. " 01/01/2023 - "Improved cfMeDIP-seq were utilized to characterize both cfDNA methylation and fragmentation profiles in 49 plasma samples from both healthy individuals and patients with breast cancer. " 07/01/2018 - "Our meta-analysis indicated that cfDNA was associated with poor PFS and OS, thus it may help to predict outcomes of patients with breast cancer. " 04/12/2011 - "The results demonstrate for the first time the existence of amplified HER2 in cfDNA in the follow-up of breast cancer patients who are otherwise disease free. " 05/22/2006 - "Analysis of RARbeta2 and RASSF1A methylation in the total cirDNA provides 95% diagnostic coverage in breast cancer patients, 60% in patients with benign lesions, and is without false-positive results in healthy women. "
3.	Aneuploidy (Aneuploid) 01/01/2022 - "In conclusion, our study has shown that genome-wide cfDNA screening for the presence of rare autosomal aneuploidies can be beneficial for both patients and their healthcare practitioners. " 01/01/2018 - "Cell-free DNA screening appears to be effective in detecting the common autosomal aneuploidies, but one-third of our cohort with high-risk results rejected confirmatory testing. " 01/01/2014 - "The possibilities of screening for other aneuploidies in the first trimester and an outline of recent methods to improve overall screening performance are highlighted and the review will suggest some possible options for the future in which Cell Free DNA techniques may become part of an improved overall screening strategy. " 04/01/2017 - "There is an evolving tension between improved screening performance for common aneuploidies offered by cfDNA testing, and the increasing diagnostic utility of molecular karyotyping. " 07/23/2023 - "This study aimed to evaluate whether crown-rump length discordance in dichorionic twins between 11 and 14 weeks of gestation is associated with a higher risk of aneuploidy, structural anomalies, or adverse perinatal outcomes and to assess the performance of cell-free DNA screening in dichorionic twin pregnancies with crown-rump length discordance. "
4.	Down Syndrome (Down's Syndrome) 04/01/2018 - "Our study has shown that first-trimester risk assessment for trisomy 21 that includes a detailed ultrasound examination as well as NT measurement and is followed by cfDNA testing is associated with a significant reduction in the false-positive rate compared with FTCS. " 11/23/2020 - "While primary cfDNA screening improved the trisomy 21 DR by 3-5%, it was more costly and more women required diagnostic testing. " 01/01/2019 - "The performance of cfDNA testing for trisomy 21 in twin pregnancy is similar to that reported in singleton pregnancy and is superior to that of the first-trimester combined test or second-trimester biochemical testing. " 01/01/2015 - "Screening for trisomy 21 by analysis of cfDNA in maternal blood is superior to that of all other traditional methods of screening, with higher DR and lower FPR. " 10/01/2023 - "Cell-free DNA testing is effective in screening for trisomy 21 in twin gestations from the first trimester of pregnancy. "
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2023 - "Efficacy of cell-free DNA methylation-based blood test for colorectal cancer screening in high-risk population: a prospective cohort study." 12/09/2022 - "Evolution of RAS Mutations in Cell-Free DNA of Patients with Tissue RAS Wild-Type Metastatic Colorectal Cancer Receiving First-Line Treatment: The PERSEIDA Study." 01/23/2018 - "The prognostic efficacy of cell-free DNA hypermethylation in colorectal cancer." 01/01/2021 - "Our study aimed to establish reference intervals and to evaluate the association between cfDNA and demographic and clinical variables, including colorectal cancer (CRC). " 08/01/2020 - "This study evaluated the clinical utility of cfDNA to predict primary or secondary resistance to EGFR blockade in patients with metastatic colorectal cancer. "

Related Drugs and Biologics

1.	Cell-Free Nucleic Acids
2.	DNA (Deoxyribonucleic Acid)
3.	Biomarkers (Surrogate Marker)
4.	dichlorobis(azomycin)platinum II
5.	Nucleosomes (Nucleosome)
6.	Circulating Tumor DNA
7.	MicroRNAs (MicroRNA)
8.	Antigens
9.	Nucleic Acids
10.	Immunoglobulin M (IgM)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Neoadjuvant Therapy
4.	Immunotherapy
5.	Aftercare (After-Treatment)