Subfamily A ATP Binding Cassette Transporter

A large, highly conserved, subfamily of ATP binding cassette transporters structurally characterized by a membrane-spanning domain composed of six ALPHA-HELICES, a large extracellular loop, nucleotide-binding domain, and a conserved cytoplasmic 80 amino acid sequence. In humans, it includes ABCA1(ATP BINDING CASSETTE TRANSPORTER 1) through ABCA10, as well as ABCA12 and ABCA13.

Also Known As:

Networked: 12 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Pahnke, Jens: 2 articles (04/2021 - 01/2021)
2.	Halliday, Glenda M: 2 articles (01/2015 - 01/2012)
3.	Kim, Woojin Scott: 2 articles (01/2015 - 01/2012)
4.	Dib, Shiraz: 1 article (04/2021)
5.	Gosselet, Fabien: 1 article (04/2021)
6.	Bascuñana, Pablo: 1 article (01/2021)
7.	Brackhan, Mirjam: 1 article (01/2021)
8.	Koldamova, Radosveta: 1 article (01/2021)
9.	Möhle, Luisa: 1 article (01/2021)
10.	Namasivayam, Vigneshwaran: 1 article (01/2021)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 04/27/2021 - "Several studies, including genome wide association studies (GWAS), have strongly suggested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer's disease (AD). " 01/01/2021 - "Strategies to gain novel Alzheimer's disease diagnostics and therapeutics using modulators of ABCA transporters." 11/15/2007 - "Accumulated evidence suggests that ABCA-transporters play critical roles in the pathogenesis of complex multifactorial disorders with a high incidence; such as atherosclerosis, age-related macula degeneration and Alzheimer's disease." 01/01/2015 - "Certain ABCA transporters regulate amyloid-β protein precursor (AβPP) processing to generate amyloid-β peptides (Aβ) and are associated with an increased risk for late-onset Alzheimer's disease (AD). "
2.	Type 2 Diabetes Mellitus (MODY) 02/01/2008 - "The aim of the present study was to investigate the relationship between R219K, M883I, and R1587K variants of the ATP-binding cassette transporter subfamily A number 1 (ABCA1) gene and response to rosiglitazone treatment in newly diagnosed patients with type 2 diabetes. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2022 - "ATP-binding cassette subfamily A (ABCA) transporters control the movement of lipids across cellular membranes and are implicated in a number of neurodegenerative diseases. " 01/01/2012 - "Lipids are transported around the brain by a group of proteins called ATP-Binding Cassette subfamily A (ABCA) transporters and in recent years there has been mounting evidence indicating that ABCA transporters regulate a number of neurodegenerative disease processes. "
4.	Frontotemporal Dementia (Semantic Dementia) 01/01/2022 - "We therefore undertook a comprehensive analysis of the expression of ABCA transporters (ABCA1-13) in five key brain regions (amygdala, inferior temporal cortex, superior frontal cortex, cerebellum and parietal cortex) in FTLD-TDP and controls. " 01/01/2022 - "These results suggest substantial dysregulation of ABCA transporters and lipid metabolism in FTLD-TDP and these changes are associated with neuroinflammation." 01/01/2022 - "However, very little is known about the role of ABCA transporters in frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), which is a common form of younger-onset dementia. "
5.	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/01/2022 - "However, very little is known about the role of ABCA transporters in frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), which is a common form of younger-onset dementia. "

Related Drugs and Biologics

1.	Rosiglitazone (Avandia)
2.	Lipids
3.	Adenosine Triphosphate (ATP)
4.	Proteins (Proteins, Gene)
5.	Biomarkers (Surrogate Marker)
6.	Peptides (Polypeptides)
7.	Amyloid (Amyloid Fibrils)

Related Therapies and Procedures

1.	Therapeutics