Pancreatitis-Associated Proteins

C-type lectins that restrict growth of bacteria in the intestinal epithelia and have bactericidal activity against gram-positive and gram-negative bacteria. They also regulate proliferation and differentiation of KERATINOCYTES following injury. Human pancreatitis-associated protein-1 (Reg3a) is overexpressed by pancreatic ACINAR CELLS in patients with CHRONIC PANCREATITIS. It is also highly expressed by pancreatic, bladder, and gastrointestinal cancer cells and may serve as a diagnostic biomarker.

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Networked: 165 relevant articles (5 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dagorn, Jean-Charles: 6 articles (01/2014 - 01/2002)
2.	Iovanna, J L: 5 articles (01/2016 - 03/2001)
3.	Iovanna, Juan L: 5 articles (09/2012 - 03/2003)
4.	Kiyama, Hiroshi: 5 articles (09/2012 - 06/2005)
5.	Zenilman, Michael E: 5 articles (07/2012 - 01/2000)
6.	Sommerburg, Olaf: 4 articles (01/2020 - 10/2010)
7.	Folch-Puy, Emma: 4 articles (11/2017 - 03/2003)
8.	Bluth, Martin H: 4 articles (07/2012 - 05/2008)
9.	Closa, Daniel: 4 articles (01/2007 - 03/2003)
10.	Xiang, Ming: 3 articles (01/2022 - 12/2014)

Related Diseases

1.	Pancreatitis 01/01/1997 - "The aims of this study were, first, to assess the specificity of serum pancreatitis associated protein (PAP) serology test and second, to evalute the usefulness of the test for prediciting complications in acute pancreatitis on admission to the hospital. " 07/14/2012 - "Acute pancreatitis in aging animals: loss of pancreatitis-associated protein protection?" 04/01/2011 - "The expression of Reg3β (pancreatitis-associated protein) is highly induced in experimental diabetes and acute pancreatitis, but its precise role has not been established. " 10/01/2010 - "Pancreatitis associated proteins (PAP) are highly upregulated in acute pancreatitis and other inflammatory states and have been shown to possess immunomodulatory properties. " 05/01/2008 - "Pancreatitis-associated proteins (PAPs) are induced in acute pancreatitis and antisense-mediated gene knockdown of PAP decreased PAP gene expression and worsened pancreatitis. "
2.	Type 2 Diabetes Mellitus (MODY) 09/01/2020 - "Association of serum regenerating islet-derived protein 3-beta and oncostatin-M levels with the risk of acute coronary syndrome in patients with type 2 diabetes mellitus - A pilot study." 07/01/2022 - "The aim of our study was to test the hypothesis that administration of Regenerating islet-derived protein 3α (Reg3α), a protein described as having protective effects against oxidative stress and anti-inflammatory activity, could participate in the control of glucose homeostasis and potentially be a new target of interest in the treatment of type 2 diabetes. "
3.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/01/2022 - "Regenerating islet-derived protein 3 gamma (Reg3g), a member of the pancreatic regenerative gene family, has been reported to improve type 1 diabetes by promoting β-cell regeneration. " 01/01/2007 - "We previously suggested that Reg proteins act as autoantigens in type 1 diabetes, based on evidence that a member of the Reg family (hepatocellular carcinoma intestine pancreas [HIP]/pancreatitis-associated protein [PAP]) was overexpressed in the islets of a patient who died after sudden onset of type 1 diabetes, and that, in NOD mice, Reg-specific T-cells adoptively transferred diabetes. "
4.	Colitis 03/01/2020 - "Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice." 11/01/2019 - "Oral delivery of pancreatitis-associated protein by Lactococcus lactis displays protective effects in dinitro-benzenesulfonic-acid-induced colitis model and is able to modulate the composition of the microbiota."
5.	Fibrosis (Cirrhosis) 01/01/2020 - "Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) confers protection against hepatic fibrosis through downregulation of transforming growth factor β receptor II."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Glucose (Dextrose)
3.	Dexamethasone (Maxidex)
4.	Transforming Growth Factors (Transforming Growth Factor)
5.	benzenesulfonic acid (benzenesulfonate)
6.	Messenger RNA (mRNA)
7.	Biomarkers (Surrogate Marker)
8.	Antimicrobial Peptides
9.	Ceruletide
10.	Chemokines

Related Therapies and Procedures

1.	Blood Transfusion (Blood Transfusions)
2.	Fecal Microbiota Transplantation