Cancer Pain

Pain that may be caused by or related to cellular, tissue, and systemic changes that occur during NEOPLASM growth, tissue invasion, and METASTASIS.

Also Known As:

Cancer-Associated Pain; Cancer-Related Pain; Neoplasm-Associated Pain; Neoplasm-Related Pain; Oncological Pain; Oncology Pain; Tumor-Associated Pain; Tumor-Related Pain; Cancer Associated Pain; Cancer Pains; Cancer Related Pain; Cancer-Associated Pains; Cancer-Related Pains; Neoplasm Associated Pain; Neoplasm Related Pain; Neoplasm-Associated Pains; Neoplasm-Related Pains; Oncological Pains; Oncology Pains; Pain, Cancer; Pain, Cancer-Associated; Pain, Cancer-Related; Pain, Neoplasm-Associated; Pain, Neoplasm-Related; Pain, Oncological; Pain, Oncology; Pain, Tumor-Associated; Pain, Tumor-Related; Pains, Cancer; Pains, Cancer-Associated; Pains, Cancer-Related; Pains, Neoplasm-Associated; Pains, Neoplasm-Related; Pains, Oncological; Pains, Oncology; Pains, Tumor-Associated; Pains, Tumor-Related; Tumor Associated Pain; Tumor Related Pain; Tumor-Associated Pains; Tumor-Related Pains

Networked: 6033 relevant articles (772 outcomes, 1175 trials/studies)

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions
- Signs and Symptoms
  - Neurologic Manifestations: 7102
    - Pain: 219111
      - Cancer Pain: 6033

Related Diseases

1.	Pain (Aches)
2.	Neoplasms (Cancer)
3.	Neuralgia (Stump Neuralgia)
4.	Chronic Pain
5.	Nausea

Experts

1.	Mercadante, Sebastiano: 84 articles (05/2022 - 05/2002)
2.	Bruera, Eduardo: 68 articles (01/2022 - 02/2002)
3.	Kaasa, Stein: 42 articles (01/2021 - 08/2002)
4.	Bhatnagar, Sushma: 40 articles (02/2022 - 06/2008)
5.	Bennett, Michael I: 38 articles (01/2022 - 02/2005)
6.	Klepstad, Pål: 35 articles (02/2020 - 08/2002)
7.	Radbruch, L: 30 articles (01/2018 - 01/2000)
8.	Caraceni, Augusto: 28 articles (03/2022 - 05/2004)
9.	Casuccio, Alessandra: 27 articles (05/2022 - 05/2002)
10.	Sjøgren, Per: 25 articles (01/2022 - 11/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cancer Pain:

1.	Opioid Analgesics (Opioids)IBA 01/01/2018 - "Opioids are highly effective for cancer pain but are associated with multiple adverse effects and risk of addiction. " 01/01/2017 - "Perceptions about the efficacy and appropriateness of opioids for the management of chronic non-cancer pain (CNCP) have dramatically transformed in recent decades. " 06/01/2014 - "This article describes the major opioid analgesics available for the treatment of cancer-related pain and reviews the key elements for safe and effective prescribing, including selection of the best drug and route, approaches to titration and long-term administration of baseline and supplemental doses, rotation from one drug to another in poorly responsive patients, and management of opioid risks." 06/01/2011 - "In general, opioids are highly effective against cancer-related pain. " 03/01/2002 - "Students agreed most strongly (mean +/- standard deviation [SD]) that the educational material on the CD-ROM was presented clearly (3.9 +/- 1.1), the CD-ROM format was easy to use (4.0 +/- 0.8), the CD-ROM course improved knowledge of opioid use for cancer pain (4.0 +/- 0.7), and the course improved understanding of opioid-related side effects (4.0 +/- 0.7). "
2.	Analgesics (Analgesic Drugs)IBA 12/01/1990 - "Many studies have demonstrated that cancer pain can be relieved in most cases by suitable analgesic medication. " 01/01/2015 - "The WHO analgesic guidelines for treatment of cancer pain have been proven safe and effective for most patients. " 03/01/2010 - "In most patients, cancer pain is effectively treated with conservative medical management consisting of oral and/or transdermal analgesics. " 01/01/1993 - "Cancer pain can be relieved with oral analgesics in most cases but 10 to 20% of patients do not respond. " 02/01/2012 - "Optimal management of breakthrough cancer pain (BTCP) requires analgesics with a rapid onset of action, consistent efficacy, improved patient acceptability and tolerability and ease of use. "
3.	Morphine (MS Contin)FDA LinkGeneric 11/01/1993 - "Intrathecal mu agonists, particularly morphine, are effective for most patients with cancer pain, though in some patients rapid tolerance or marked resistance develop. " 06/01/2021 - "The cisterna Intrathecal Drug Delivery system (IDDS) with morphine has proven to be effective in treating refractory cancer pain above the middle thoracic vertebrae level in some countries. " 09/01/2020 - "60% of the providers were certain that cancer pain cannot be relieved by morphine while only 33% believed that morphine can cause complete relief. " 04/01/2001 - "In paediatric haematology/oncology, pain control by oral long-acting morphine proved to be safe and effective even in the very young patients. " 02/01/2021 - "Targeting microglia different polarization states by the inhibition of their deleterious pro-inflammatory neurotoxicity and/or enhancing their beneficial anti-inflammatory protective function seems to be an effective treatment for cancer pain and morphine tolerance."
4.	Fentanyl (Sublimaze)FDA LinkGeneric 01/01/2014 - "Advancements in the formulations and delivery of fentanyl have provided a safer and more effective treatment for breakthrough cancer pain. " 04/01/2016 - "Transdermal fentanyl is effective for the treatment of moderate to severe cancer-related pain but is unsuitable for fast titration. " 12/01/2013 - "Fentanyl matrix use is known to be effective in patients with chronic cancer pain. " 01/01/2013 - "A fentanyl patch is widely used for the treatment of cancer pain. " 03/01/2004 - "Evaluation of safety and efficacy of transdermal therapeutic system-fentanyl in adult patients with gynecological cancer-related pain."
5.	Oxycodone (Oxycontin)FDA LinkGeneric 08/05/2004 - "CR oxycodone is a good alternative in the treatment of non-cancer pain and can be recommended as first-line treatment for the above-mentioned indications." 05/01/2011 - "Oxycodone is widely used for the treatment of cancer pain, but little is known of its pharmacokinetics in cancer pain patients. " 10/01/2009 - "While our clinical audit is a primitive one, we may conclude that the continuous subcutaneous administration of the compound oxycodone injection should be effective and safe in clinical use for cancer pain control." 01/01/2022 - "This study aimed to explore optimal titration strategy of controlled-release (CR) oxycodone hydrochloride in patients with cancer pain. " 06/02/2021 - "This model is an important starting point for further studies to optimize oxycodone dosing regiments in patients with cancer-related pain."
6.	Methadone (Dolophine)FDA LinkGeneric 09/01/2014 - "The proven therapeutic efficacy of methadone in cancer pain is hindered by a challenging pharmacokinetic-pharmacodynamic profile, considerable interpatient variation, and increasing concern about the complexities of dosing. " 11/01/2017 - "Methadone has been shown to be effective for cancer pain. " 03/01/2013 - "Methadone is effective in the treatment of cancer-related pain in adults. " 02/01/2020 - "Emerging Challenges to the Safe and Effective Use of Methadone for Cancer-Related Pain in Paediatric and Adult Patient Populations." 10/03/2023 - "This approach is peculiar because methadone is not used as a first-line treatment in cancer pain management and is not often used as a second-line treatment as well. "
7.	TabletsIBA 01/01/2008 - "OxyContin tablets demonstrated fast onset of cancer pain control, superior efficacy in relieving both moderate and severe cancer pain and a good safety profile." 01/01/2021 - "The application of low-dose oxycodone hydrochloride sustained-release tablets as the initial medication for patients with mild cancer pain was safe and effective, and the adverse reactions were easy to manage." 09/01/2019 - "Sublingual fentanyl tablets (SFTs) have been shown to be a safe and effective option in controlling breakthrough cancer pain (BTcP). " 06/01/2012 - "To compare the efficacy of fentanyl effervescent buccal tablet (FBT), sublingual oral transmucosal fentanyl citrate (ODT) and compressed lozenge oral transmucosal fentanyl citrate (OTFC) for the treatment of breakthrough cancer pain (BTcP). " 06/01/2021 - "Efficacy, safety, and tolerability of sublingual fentanyl orally disintegrating tablet in the treatment of breakthrough cancer pain: a randomized, double-blind, placebo-controlled study."
8.	CannabinoidsIBA 11/01/2019 - "Cannabinoids not very effective for chronic non-cancer pain." 01/01/2020 - "Good preclinical animal data and a large body of observational evidence point to the potential efficacy of cannabinoids for cancer pain management. " 08/27/2022 - "Various preclinical and observational studies have aimed to prove that cannabinoids could be effective in cancer pain management. " 06/14/2017 - "We sought to determine whether cannabinoids are an effective treatment for chronic non-cancer pain. " 06/14/2017 - "Are cannabinoids an effective treatment for chronic non-cancer pain?"
9.	Hydromorphone (Dilaudid)FDA LinkGeneric 09/15/2009 - "The results of this extension study suggest that long-term repeated dosing with once-daily OROS(R) hydromorphone can be beneficial in the continuing management of persistent, moderate-to-severe cancer pain." 05/01/1996 - "A randomized, double-blind, double-dummy, crossover trial comparing the safety and efficacy of oral sustained-release hydromorphone with immediate-release hydromorphone in patients with cancer pain. " 09/15/1994 - "Controlled release hydromorphone administered every 12 hours is as effective as immediate release hydromorphone administered every 4 hours in the management of patients with chronic severe cancer pain. " 05/01/1996 - "To evaluate the safety and efficacy of a new slow-release preparation of hydromorphone (SRH) in the treatment of cancer pain. " 09/15/2009 - "An open-label, 1-year extension study of the long-term safety and efficacy of once-daily OROS(R) hydromorphone in patients with chronic cancer pain."
10.	Ketamine FDA LinkGeneric 06/01/2011 - "to oral ketamine is safe and effective in cancer pain patients." 01/01/2022 - "The objective of our study was to determine safety and pharmacology (pharmacokinetics and preliminary efficacy) of intranasal (IN) ketamine for uncontrolled cancer-related pain. " 01/01/2019 - "Economic evaluation of the randomised, double-blind, placebo-controlled study of subcutaneous ketamine in the management of chronic cancer pain." 05/01/2021 - "The aim of this retrospective was to analyze the efficacy of subanesthetic ketamine infusion in the ambulatory setting over an extended follow-up period of 3 months for symptoms related to refractory cancer pain. " 01/01/2018 - "Although early studies of intranasal ketamine are promising in a number of indications, information is more limited in its use as an adjunct in cancer-related pain. "

Therapies and Procedures

1.	Therapeutics 11/01/2017 - "Thus a panel of Latin-American experts met in Madrid in March 2017 in order to review the published literature, discuss the best approach for cancer pain classification and evaluation and also make recommendations of pharmacological and nonpharmacological therapies for cancer pain management improvement in Latin-American countries. " 03/01/2014 - "Improvement in cancer-related pain resulting from antitumor therapy is an important treatment benefit that can support drug approval and labeling claims when adequately measured if study results demonstrate statistically and clinically significant findings. " 10/01/2014 - "The CPGTs significantly improved standardization, efficiency, and efficacy of cancer pain therapy in China. " 01/01/2022 - "Improvement in disease control with more effective therapies may reduce cancer pain in this population." 01/01/2017 - "The development of novel treatment options will hopefully lead to more effective therapies in the treatment of cancer-related pain."
2.	Analgesia 03/01/2000 - "To determine the most efficacious, cost-effective, and user-friendly option to manage cancer pain, several factors must be considered: the ability of the patient to use a specific type of delivery system, the efficacy of that system to deliver acceptable analgesia, the ease of use for the patient and family, the potential or actual complications associated with that system, and the cost. " 09/01/2004 - "Epidural and intrathecal analgesia is effective in treating refractory cancer pain." 09/01/2023 - "Effective and safe analgesia can be provided with multimodal analgesia to manage pediatric cancer pain." 08/01/2005 - "With their skills and expertise in regional analgesia and pharmacological analgesia, anaesthesiologists have improved management of severe cancer pain. " 08/01/1985 - "Over time, there was a consistent mean improvement in analgesia scores ranging from 50% to 70% of the control levels for 16 of the patients with cancer-related pain. "
3.	Pain Management 01/01/2021 - "Cancer pain prevalence is high despite well-established international guidelines on pain management and improved accessibility to treatment. " 12/10/2018 - "In this review, we explore the possible reasons for the ongoing high prevalence of cancer pain and discuss possible future directions for improvement in personalised pain management. " 08/01/2012 - "Though majority of patients with cancer pain can be effectively treated with conventional medical management, still a significant portion of patients required some form of interventional pain management techniques. " 09/01/1996 - "Peripheral nerve catheterization proved beneficial in two patients who presented with difficult pain management problems and should be more widely considered for the relief of severe cancer-related pain in both the upper and lower limbs." 01/01/2023 - "Through alleviating stigma, patients may be better able to make decisions regarding their pain management which lead to freedom from cancer-related pain and improved QoL."
4.	Drug Therapy (Chemotherapy) 01/01/2019 - "Meta-analysis of 19 out of 34 reviews showed the followings: (1) acupuncture had a beneficial effect on the frequency of hot flushes, (2) yoga had a beneficial effect on depression and health-related QOL, (3) mindfulness-based stress reduction (MBSR) had a beneficial effect on anxiety and depression, (4) combination of herbal medicine and chemotherapy synergistically improved clinical outcomes, (5) acupuncture did not show significant effect on the severity of hot flushes and cancer-related pain, (6) yoga was unable to be confirmed as having an effect on cancer-related pain and physical well-being. " 01/01/2016 - "Acupuncture plus drug therapy is more effective than conventional drug therapy alone for cancer-related pain. " 03/01/1987 - "Drug therapy represents the mainstay of treatment for patients with cancer pain. " 01/01/2021 - "Recent studies have also demonstrated efficacy for cancer-related pain and chemotherapy induced neuropathy with these techniques. " 11/13/2023 - "Therefore, drug and non-drug therapies should be applied even more consistently to patients with tumor-associated pain. "
5.	Palliative Care (Palliative Therapy) 01/01/2022 - "This study was the first to test the efficacy of a psychoeducational cancer pain self-management intervention in a German-speaking context, with most patients receiving palliative care. " 03/01/1994 - "Data from three clinical studies are also presented, which showed the efficacy of the WHO Method of Cancer Pain Relief among samples of Philippine patients, and that cancer pain relief alone did not significantly improve overall quality of life, demonstrating the need for comprehensive palliative care." 01/01/2020 - "Unfolding Role of Erector Spinae Plane Block for the Management of Chronic Cancer Pain in the Palliative Care Unit." 01/01/2003 - "Nevertheless, recognition of the critical need for improved cancer pain management was the genesis of modern palliative care. " 10/16/2023 - "This study was conducted as a preplanned secondary analysis of a multicenter prospective longitudinal study of inpatients with cancer pain who received specialized palliative care for cancer pain relief. "