PTB-Associated Splicing Factor

An RNA splicing factor that also binds DNA. It is essential for pre-mRNA spicing in the formation of early SPLICEOSOMES and catalytic step II. It binds specifically to polypyrimidine tracts in INTRONS and is involved in the regulation of ALTERNATIVE SPLICING by SIGNAL TRANSDUCTION PATHWAYS.

Also Known As:

PSF Splicing Factor; Polypyrimidine Tract-Binding Protein-Associated Splicing Factor; SFPQ Protein; Splicing Factor Proline-Glutamine Rich Protein; PTB Associated Splicing Factor; Polypyrimidine Tract Binding Protein Associated Splicing Factor; Splicing Factor Proline Glutamine Rich Protein; Splicing Factor, PSF; Splicing Factor, PTB-Associated

Networked: 16 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Haniu, Hisao: 3 articles (01/2015 - 01/2013)
2.	Matsuda, Yoshikazu: 3 articles (01/2015 - 01/2013)
3.	Tsukahara, Tamotsu: 3 articles (01/2015 - 01/2013)
4.	Grindheim, Ann Kari: 1 article (10/2021)
5.	Hollås, Hanne: 1 article (10/2021)
6.	Patil, Sudarshan S: 1 article (10/2021)
7.	Romanyuk, Sofya: 1 article (10/2021)
8.	Sakya, Siri Aastedatter: 1 article (10/2021)
9.	Saraste, Mikko E V: 1 article (10/2021)
10.	Strand, Elin: 1 article (10/2021)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2018 - "By considering its promotive effects on malignant tumor behaviors, in the present study, it was identified that upregulated MALAT-1 released the binding of PTB-associated splicing factor (PSF) to its target gene, GAGE6, and thus promoted proliferation, migration and invasion of A549 cells following hypoxia exposure. " 01/01/2022 - "Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript-1." 04/20/2013 - "Several lines of evidence support the notion that increased RNA-binding ability of polypyrimidine tract-binding (PTB) protein-associated splicing factor (PSF) and aberrant expression of long non-coding RNAs (lncRNAs) are associated with mouse and human tumors. " 04/23/2020 - "These kinases play an important role controlling the expression of specific proteins involved in cell cycle, cell survival and cell motility via eukaryotic initiation factor 4E (eIF4E) regulation, but also through other substrates such as heterogeneous nuclear ribonucleoprotein A1, polypyrimidine tract-binding protein-associated splicing factor and Sprouty 2. In this review, we provide an overview of the role of MNK in human cancers, describing the studies conducted to date to elucidate the mechanism involved in the action of MNKs, as well as the development of MNK inhibitors in different hematological cancers and solid tumors."
2.	Colonic Neoplasms (Colon Cancer) 01/01/2013 - "Our previous study demonstrated that PTB-associated splicing factor (PSF) is an important regulator of cell death and plays critical roles in the survival and growth of colon cancer cells. " 01/01/2015 - "Our previous study suggested that PTB-associated splicing factor (PSF) is a PPARγ-interacting protein and growth regulator of colon cancer cells. " 01/01/2013 - "Here, using a proteomic approach, we identify PTB-associated splicing factor (PSF) as a novel PPARγ-interacting protein and demonstrate that PSF is involved in several important regulatory steps of colon cancer cell proliferation. " 01/01/2013 - "PTB-associated splicing factor (PSF) is a PPARγ-binding protein and growth regulator of colon cancer cells."
3.	Hypoxia (Hypoxemia) 07/01/2018 - "By considering its promotive effects on malignant tumor behaviors, in the present study, it was identified that upregulated MALAT-1 released the binding of PTB-associated splicing factor (PSF) to its target gene, GAGE6, and thus promoted proliferation, migration and invasion of A549 cells following hypoxia exposure. " 07/01/2018 - "Hypoxia exposure upregulates MALAT-1 and regulates the transcriptional activity of PTB-associated splicing factor in A549 lung adenocarcinoma cells."
4.	Renal Cell Carcinoma (Grawitz Tumor) 01/11/2007 - "A subset of papillary renal cell carcinomas (RCC) is characterized by the expression of a TFE3 fusion protein, where the fusion partner can be any of the several proteins identified so far such as PSF (PTB associated splicing factor), NonO, PRCC, CLTC and ASPL. " 01/01/2016 - "The analysis of proteins from three human sarcomas cell lines (RD, U-2 OS and SK-UT-1B), three human renal adenocarcinomas cell lines (A-498, 769-P and OKP-GS), and two prostate adenocarcinomas cell lines (DU-145 and PC-3) revealed several electrophoretic isoforms of SFPQ protein. "
5.	Retinal Neovascularization 01/01/2021 - "In Vldlr-/- mice, we used fundus fluorescein angiography and retinal flat mount staining to observe the effect of polypyrimidine tract-binding protein-associated splicing factor (PSF) on pathological retinal neovascularization in vivo. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Eukaryotic Initiation Factor-4E
3.	Phosphotransferases (Kinase)
4.	Heterogeneous Nuclear Ribonucleoprotein A1
5.	Polypyrimidine Tract-Binding Protein
6.	Carrier Proteins (Binding Protein)
7.	RNA (Ribonucleic Acid)
8.	PPAR gamma
9.	Poly(A)-Binding Proteins (Poly(A)-Binding Protein)
10.	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)