IFIH1 Interferon-Induced Helicase

A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.

Also Known As:

Interferon-Induced Helicase, IFIH1; CADM-140 Autoantigen; Helicard; IFIH1 Protein; Interferon Induced with Helicase C Domain 1; Interferon-Induced Helicase C Domain-Containing Protein 1; Melanoma Differentiation-Associated Protein 5; Autoantigen, CADM-140; CADM 140 Autoantigen; Helicase, IFIH1 Interferon-Induced; Interferon Induced Helicase C Domain Containing Protein 1; Interferon Induced Helicase, IFIH1; Melanoma Differentiation Associated Protein 5

Networked: 133 relevant articles (1 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ho, Roy: 2 articles (11/2022 - 01/2022)
2.	Lam, Tommy Tsz-On: 2 articles (11/2022 - 01/2022)
3.	Lau, Chak Sing: 2 articles (11/2022 - 01/2022)
4.	Li, Wai Ling: 2 articles (11/2022 - 01/2022)
5.	Mok, Chi Chiu: 2 articles (11/2022 - 01/2022)
6.	So, Ho: 2 articles (11/2022 - 01/2022)
7.	So, Jacqueline: 2 articles (11/2022 - 01/2022)
8.	Tam, Lai-Shan: 2 articles (11/2022 - 01/2022)
9.	Wong, Victor Tak-Lung: 2 articles (11/2022 - 01/2022)
10.	Wang, Qian: 2 articles (01/2021 - 09/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "Recently three new myositis-specific autoantibodies (MSA) predicting the risk of cancer have been discovered: melanoma differentiation-associated protein 5 (anti-MDA-5), transcription intermediary factor 1γ (TIF-1γ), and nuclear matrix protein NXP-2. " 01/01/2023 - "No cancer association, positive or negative, was observed for patients with antisynthetase, anti-melanoma differentiation-associated protein 5 (anti-MDA-5), or anti-hydroxymethylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies. " 11/01/2021 - "BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy against distant untreated tumors. "
2.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/01/2012 - "Therefore, the aim of this study is to provide evidence for the association between type 1 diabetes and two polymorphisms (rs3747517, rs1990760) from interferon induced with helicase C domain 1 (IFIH1). " 01/01/2018 - "Association between interferon-induced helicase (IFIH1) rs1990760 polymorphism and seasonal variation in the onset of type 1 diabetes mellitus." 12/01/2013 - "The role of interferon induced with helicase C domain 1 (IFIH1) in the development of type 1 diabetes mellitus." 03/01/2013 - "The Interferon-induced with helicase C domain 1 (IFIH1) gene has been hypothesized as involved in the viral etiology of type 1 diabetes (T1D) and other autoimmune disorders, since it is implicated in viral recognition. " 03/01/2013 - "Interferon induced with helicase C domain 1 (IFIH1): trends on helicase domain and type 1 diabetes onset."
3.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 06/01/2018 - "Evaluation of Impact of Interferon-Induced Helicase C Domain-Containing Protein 1 Gene in Egyptian Systemic Lupus Erythematosus Patients and its Relationship With Vascular Manifestations of the Disease." 06/01/2018 - "This study aims to investigate the impact of interferon-induced helicase C domain-containing protein 1 (IFIH1) gene single nucleotide polymorphism on interferon pathway signaling in systemic lupus erythematosus (SLE) patients specifically with vascular affection. " 10/01/2010 - "The aim of the present study was to evaluate whether the interferon-induced helicase (IFIH1) Ala946Thr (rs1990760 A>G) polymorphism is associated with susceptibility to systemic lupus erythematosus (SLE) and dermatomyositis (DM) or polymyositis (PM) in the Japanese population. " 10/01/2010 - "Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis/polymyositis." 10/01/2014 - "This study aimed to demonstrate possible associations between genetic polymorphisms in Toll-like receptor 3, interferon induced with helicase C domain 1 (IFIH1) and DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 and systemic lupus erythematosus (SLE), including the phenotypes lupus nephritis and malar rash, as well as the presence of autoantibodies against nucleic acid-containing complexes. "
4.	Dermatomyositis (Dermatopolymyositis) 08/01/2023 - "Cardiac involvement in a case of juvenile dermatomyositis with positive anti-melanoma differentiation associated protein 5 antibody." 04/28/2021 - "Melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (DM) displays unique cutaneous and pathologic features. " 01/01/2021 - "Objective: To elucidate the 18F-fluorodeoxyglucose (FDG) PET/CT characteristics and its prognostic value in the patients with anti-melanoma differentiation associated protein 5 antibody positive (anti-MDA5+) dermatomyositis (DM). " 06/01/2020 - "Rapidly progressive anti-melanoma differentiation-associated protein 5 (MDA-5)-positive dermatomyositis." 01/01/2019 - "Antihelix/helix violaceous macules in Japanese patients with anti-melanoma differentiation-associated protein 5 (MDA5) antibody-associated dermatomyositis."
5.	Infections 10/01/2014 - "HepG2-HFL cells represent a new system to study the interaction between HCV and the innate immune system, solidifying the importance of IFN-λ in hepatic response to HCV infection and revealing non-redundant roles of RIG-I and melanoma differentiation-associated protein 5 in HCV recognition and repression of infection." 12/01/2018 - "The RIG-I-like receptor, melanoma differentiation-associated protein 5 (MDA5), is also required for IFN induction and IRF3 phosphorylation during MNoV infection. " 01/01/2020 - "Previous research has shown that infection with coronaviruses activates an innate immune response upon sensing of viral RNA by interferon-induced with helicase C domain 1 (IFIH1), also known as MDA5. " 01/01/2019 - "Infectious bursal disease virus (IBDV) infection triggers the induction of type I IFN, which is mediated by melanoma differentiation-associated protein 5 recognition of the viral genomic double-stranded RNA (dsRNA). " 02/01/2016 - "Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks."

Related Drugs and Biologics

1.	Toll-Like Receptor 3
2.	Poly I-C
3.	eIF-2 Kinase (eIF 2 Kinase)
4.	BO-112
5.	Interferons
6.	Proteins (Proteins, Gene)
7.	Tretinoin (Retinoic Acid)
8.	Autoantibodies
9.	Toll-Like Receptors (Toll-Like Receptor)
10.	Viral RNA

Related Therapies and Procedures

1.	Immunotherapy