Cytochrome P450 Family 21

A cytochrome P450 enzyme family that includes STEROID 21-HYDROXYLASE, which functions in the biosynthesis of STEROIDS.

Also Known As:

CYP21 Enzymes; CYP21 Family

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 21: 4
        Steroid 21-Hydroxylase: 743
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - Cytochrome P450 Family 21: 4
      - Steroid 21-Hydroxylase: 743
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 21: 4
        Steroid 21-Hydroxylase: 743

Experts

1.	Cai, Yanna: 1 article (11/2018)
2.	Cheng, Jing: 1 article (11/2018)
3.	Feng, Zhichun: 1 article (11/2018)
4.	Liu, Li: 1 article (11/2018)
5.	Su, Ling: 1 article (11/2018)
6.	Wu, Dongyan: 1 article (11/2018)
7.	Yin, Xi: 1 article (11/2018)
8.	Chen, Wuyan: 1 article (02/2012)
9.	Finkielstain, Gabriela P: 1 article (02/2012)
10.	McDonnell, Nazli B: 1 article (02/2012)

Related Diseases

1.	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 07/01/1999 - "The analysis of the evolutionary mutation pattern, and the pattern of pseudogenes and damaged alleles of the CYP21 family (found in patients with congenital adrenal hyperplasia) does not confirm the widely accepted hypothesis that mutations arising in pseudogenes are transduced to normal alleles of the CYP21 gene through gene conversion." 11/01/2018 - "Classical 21-hydroxylase deficiency (21-OHD) due to mutations in the cytochrome P450 family 21 subfamily A member 2 (CYP21A2) gene is the most common type of congenital adrenal hyperplasia (CAH). " 03/01/2011 - "The high homology between the CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2) and CYP21A1P (cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene) genes is the major obstacle to risk-free genetic diagnosis of congenital adrenal hyperplasia, especially regarding the quantification of gene dosage. " 02/01/2012 - "Chimeric CYP21A1P/CYP21A2 genes, caused by homologous recombination between CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2) and its highly homologous pseudogene CYP21A1P (cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene), are common in patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD). "
2.	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 11/01/2018 - "Classical 21-hydroxylase deficiency (21-OHD) due to mutations in the cytochrome P450 family 21 subfamily A member 2 (CYP21A2) gene is the most common type of congenital adrenal hyperplasia (CAH). " 02/01/2012 - "Chimeric CYP21A1P/CYP21A2 genes, caused by homologous recombination between CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2) and its highly homologous pseudogene CYP21A1P (cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene), are common in patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD). "

Related Drugs and Biologics

1.	Peptides (Polypeptides)