Forkhead Box Protein M1

A forkhead box transcription factor that is expressed primarily in adult organs which contain proliferating cells such as the thymus, testis, ovary, and small intestine. It controls the expression of CELL CYCLE genes essential for DNA REPLICATION and MITOSIS, and also functions in DNA REPAIR.

Also Known As:

Networked: 137 relevant articles (1 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lam, Eric W-F: 4 articles (09/2019 - 01/2010)
2.	Kalinichenko, Vladimir V: 4 articles (01/2019 - 02/2006)
3.	Huang, Suyun: 4 articles (01/2017 - 04/2006)
4.	Xie, Keping: 4 articles (02/2015 - 04/2006)
5.	Wang, I-Ching: 4 articles (08/2009 - 12/2005)
6.	Kalin, Tanya V: 3 articles (01/2019 - 02/2006)
7.	Cui, Jiujie: 3 articles (02/2015 - 01/2013)
8.	Millour, Julie: 3 articles (09/2011 - 01/2010)
9.	Costa, Robert H: 3 articles (07/2008 - 12/2005)
10.	Major, Michael L: 3 articles (07/2008 - 12/2005)

Related Diseases

1.	Sepsis (Septicemia) 01/01/2019 - "Hif1af/f/Tie2Cre+ lungs exhibited marked decrease of EC proliferation during recovery after sepsis challenge, which was associated with inhibited expression of forkhead box protein M1 (Foxm1), a reparative transcription factor. "
2.	Neoplasms (Cancer) 09/29/2022 - "We found that the novel FOXM1-PROTAC efficiently entered cells and induced degradation of FOXM1 protein, which strongly inhibits viability as well as migration and invasion in various cancer cell lines, and suppressed tumor growth in HepG2 and MDA-MB-231 cells xenograft mouse models, without detected toxicity in normal tissues. " 01/01/2021 - "Forkhead box protein M1 (FOXM1) is a crucial regulator of cancer development and chemoresistance. " 01/01/2021 - "Forkhead box protein M1 (FOXM1) is a pivotal regulator of G2/M cell cycle progression in many types of cancer. " 01/01/2019 - "Our previous work demonstrated that miR-671-5p serves as a tumor suppressor by targeting Forkhead box protein M1 (FOXM1)-mediated epithelial-to-mesenchymal transition (EMT) in BC. " 01/01/2019 - "RCM-1 decreased FOXM1 protein in the tumors, reduced tumor cell proliferation, and increased tumor cell apoptosis. "
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2019 - "Forkhead box protein M1 was identified as a direct target of microRNA-215-3p and reexpression of forkhead box protein M1 reversed the suppressive impacts of microRNA-215-3p on the growth, mobility, and invasion abilities of colorectal cancer cell. " 01/01/2017 - "The overexpressions of HER2 and FOXM1 protein in colorectal cancer correlate with their clinicopathological characteristics and prognosis. " 05/01/2016 - "Overexpression of forkhead box protein M1 (FOXM1) plays a critical role in colorectal cancer." 10/01/2016 - "Expression and potential correlation among Forkhead box protein M1, Caveolin-1 and E-cadherin in colorectal cancer." 10/01/2016 - "The aim of the present study was to investigate the expression and functions of Forkhead box protein M1 (FoxM1), Caveolin-1 (Cav-1) and E-cadherin in colorectal cancer (CRC), and to determine the correlations among these proteins in CRC development and progression. "
4.	Glioma (Gliomas) 01/01/2022 - "The findings obtained in our study indicate that HULC stabilizes the FOXM1 protein by ubiquitination to upregulate the expression of AGR2 and HIF-1α, which further promote the glycolysis of and maintain the stemness of GSCs, to enhance the tumorigenicity of GSCs, highlighting a novel therapeutic target for glioma." 09/01/2017 - "In vivo studies indicated that ectopic expression of miR-216b impeded the proliferation of glioma xenograft tumours in nude mice, coupled with a decreased in FoxM1 protein expression and the percentage of Ki-67-positive tumour cells. " 04/01/2006 - "The level of FoxM1 protein expression in human glioma tissues was directly correlated with the glioma grade. " 04/01/2018 - "MicroRNA-320 Enhances Radiosensitivity of Glioma Through Down-Regulation of Sirtuin Type 1 by Directly Targeting Forkhead Box Protein M1." 04/01/2018 - "Here, RT-qPCR assay was used to assess the expressions of miR-320 and forkhead box protein M1 (FoxM1) mRNA in glioma tumor tissues and cells. "
5.	Neoplasm Metastasis (Metastasis) 01/01/2023 - "We further found that LINC00857 upregulates FOXM1 protein expression and thus accelerates metastasis in vitro and in vivo. " 01/01/2019 - "In TNBC, forkhead box protein M1 (FOXM1)was found to be an hsa-miR-4756-3p target gene, and FOXM1 knockout completely inhibited hsa-miR-4756-3p-induced cell migration and metastasis, TGF-β1 signalling, and epithelial mesenchymal signal activation, which indicated that hsa-miR-4756-3p functions via the FOXM1-TGFβ1-EMT axis." 01/01/2017 - "Our previous study indicated that miR-370 was able to target forkhead box protein M1 (FOXM1) to inhibit cell growth and metastasis in human osteosarcoma cells. " 01/01/2023 - "Using genetic approaches and small molecules that destabilize the FOXM1 protein, we found that targeting this mechanism induced G2/M cell-cycle arrest and apoptosis, blocked tumor progression, and impaired metastasis. " 04/01/2022 - "A subset of STIL translocate into nucleus and associate with FOXM1 (Forkhead box protein M1) to promote tumor metastasis and stemness via FOXM1-mediated downstream target genes. "

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Proteins (Proteins, Gene)
3.	Phosphotransferases (Kinase)
4.	Cruciform DNA (Holliday Junctions)
5.	Vaccines
6.	Peptides (Polypeptides)
7.	Caveolin 1
8.	STAT1 Transcription Factor
9.	Metalloproteases (Metalloproteinases)
10.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics