ERG1 Potassium Channel

One of three members of the ether-a-go-go (EAG) POTASSIUM CHANNELS gene family comprising ether-a-go-go (eag), eag-like (elk) and eag-related (erg) subfamilies. Ether-a-go-go-related gene 1 (ERG1) also known as KCNH2, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel that plays an essential role in the final repolarization of ventricular action potential. Loss-of-function mutations in human hERG1 is associated with life-threatening ARRHYTHMIA.

Also Known As:

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dong, Mei: 2 articles (06/2019 - 12/2017)
2.	Zhi, Duo: 2 articles (06/2019 - 12/2017)
3.	Alvarez, Chikezie K: 1 article (03/2022)
4.	Smith, Emily: 1 article (03/2022)
5.	Weissler-Snir, Adaya: 1 article (03/2022)
6.	Fang, Yongkang: 1 article (09/2021)
7.	Jia, Yuchao: 1 article (09/2021)
8.	Kang, Huicong: 1 article (09/2021)
9.	Kirsch, Heidi: 1 article (09/2021)
10.	Lan, Lili: 1 article (09/2021)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2019 - "The human ether-a-go-go-related potassium channel 1 (hERG1) is a functional component of the voltage-gated Kv11.1 potassium channel, which is commonly described as a crucial factor in the tumorigenesis of a variety of tumors. " 12/01/2017 - "The human ether-a-go-go-related potassium channel 1 (hERG1) is a component of the voltage-gated Kv11.1 potassium channel, which has been recently indicated to have a crucial role in the tumorigenesis of multiple tumors, including pancreatic carcinoma. " 01/01/2020 - "Five core targets including potassium voltage-gated channel subfamily H member 2 (KCNH2), cyclin-dependent kinase 1 (CDK1), matrix metalloproteinase 2 (MMP2), mitogen-activated protein kinase1 (MAPK1), and tumor protein p53 (TP53) and 29 core compounds (beta-sitosterol, quercetin, kaempferol, etc.) were collected. "
2.	Carcinogenesis 06/01/2019 - "The human ether-a-go-go-related potassium channel 1 (hERG1) is a functional component of the voltage-gated Kv11.1 potassium channel, which is commonly described as a crucial factor in the tumorigenesis of a variety of tumors. " 12/01/2017 - "The human ether-a-go-go-related potassium channel 1 (hERG1) is a component of the voltage-gated Kv11.1 potassium channel, which has been recently indicated to have a crucial role in the tumorigenesis of multiple tumors, including pancreatic carcinoma. "
3.	Long QT Syndrome 01/01/2019 - "Heterologous expression systems play a vital role in the characterization of potassium voltage-gated channel subfamily H member 2 (KCNH2) gene mutations, such as E637K which is associated with long QT syndrome type 2 (LQT2). " 09/04/2021 - "Long QT syndrome with potassium voltage-gated channel subfamily H member 2 gene mutation mimicking refractory epilepsy: case report."
4.	Pancreatic Neoplasms (Pancreatic Cancer) 12/01/2017 - "The human ether-a-go-go-related potassium channel 1 (hERG1) is a component of the voltage-gated Kv11.1 potassium channel, which has been recently indicated to have a crucial role in the tumorigenesis of multiple tumors, including pancreatic carcinoma. "
5.	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 03/01/2022 - "Dual myosin binding protein C3 and potassium voltage-gated channel subfamily H member 2 co-inherited pathogenic variants in a patient with hypertrophic cardiomyopathy and long QT 2 syndrome: A case report."

Related Drugs and Biologics

1.	Potassium Channels (Potassium Channel)
2.	Matrix Metalloproteinase 2 (Gelatinase A)
3.	CDC2 Protein Kinase (Protein p34cdc2)
4.	Quercetin
5.	Proteins (Proteins, Gene)
6.	Myosins (Myosin)
7.	Mitogens
8.	Ion Channels (Ion Channel)
9.	Ether (Diethyl Ether)
10.	Carrier Proteins (Binding Protein)