Methyl-Accepting Chemotaxis Proteins

Transmembrane sensor receptor proteins that are central components of the chemotactic systems of a number of motile bacterial species which include ESCHERICHIA COLI and SALMONELLA TYPHIMURIUM. Methyl-accepting chemotaxis proteins derive their name from a sensory adaptation process which involves methylation at several glutamyl residues in their cytoplasmic domain. Methyl-accepting chemotaxis proteins trigger chemotactic responses across spatial chemical gradients, causing organisms to move either toward favorable stimuli or away from toxic ones.

Also Known As:

MACP-I; MACP-II; Methyl Accepting Chemotaxis Protein 1; Methyl Accepting Chemotaxis Protein 2; Methyl Accepting Chemotaxis Protein 3; Methyl-Accepting Chemotaxis Protein I; Methyl-Accepting Chemotaxis Protein II; Methyl-Accepting Chemotaxis Protein III; Chemotaxis Protein, Methyl-Accepting; Chemotaxis Proteins, Methyl-Accepting; Methyl Accepting Chemotaxis Protein; Methyl Accepting Chemotaxis Protein I; Methyl Accepting Chemotaxis Protein II; Methyl Accepting Chemotaxis Protein III; Methyl Accepting Chemotaxis Proteins; Protein, Methyl-Accepting Chemotaxis; Proteins, Methyl-Accepting Chemotaxis; Methyl-Accepting Chemotaxis Protein

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Methyl-Accepting Chemotaxis Proteins: 9

Experts

1.	Imada, Katsumi: 1 article (01/2019)
2.	Kawagishi, Ikuro: 1 article (01/2019)
3.	Nishiyama, So-Ichiro: 1 article (01/2019)
4.	Sumita, Kazumasa: 1 article (01/2019)
5.	Takahashi, Yohei: 1 article (01/2019)
6.	Chen, Changjun: 1 article (07/2016)
7.	Han, Xu: 1 article (07/2016)
8.	Ren, Weichao: 1 article (07/2016)
9.	Shao, Wenyong: 1 article (07/2016)
10.	Zhou, Mingguo: 1 article (07/2016)

Related Diseases

1.	Infections 01/01/2016 - "This pathway required the methyl-accepting chemotaxis protein (MCP) Tsr and energy taxis toward host-derived nitrate, which we found to be generated by inducible nitric oxide synthase (iNOS) in the ileal mucosa prior to infection. " 03/01/2015 - "The results also indicate the importance of a group of proteins that may not be directly related to the classical virulence factors, but that are likely fundamental to the success of the initial stages of the infection, such as methyl-accepting chemotaxis protein (Mcp) and phosphate specific transport (Pst). " 01/01/2023 - "As expected, enrichment in methyl-accepting chemotaxis protein, an integral membrane protein involved in directed motility of microbes to chemical cues and environment, occurred prior to circumcision, while the filamentous hemagglutinin pathway (a strong immunogenic protein) was depleted after circumcision CONCLUSIONS: Our results offer greater insight into the host-microbiota relationship of penile circumcision and may serve to lay the groundwork for future studies focused on drivers of inflammation, infection, and oncogenesis. "
2.	Carcinogenesis 01/01/2023 - "As expected, enrichment in methyl-accepting chemotaxis protein, an integral membrane protein involved in directed motility of microbes to chemical cues and environment, occurred prior to circumcision, while the filamentous hemagglutinin pathway (a strong immunogenic protein) was depleted after circumcision CONCLUSIONS: Our results offer greater insight into the host-microbiota relationship of penile circumcision and may serve to lay the groundwork for future studies focused on drivers of inflammation, infection, and oncogenesis. "
3.	Inflammation (Inflammations) 01/01/2023 - "As expected, enrichment in methyl-accepting chemotaxis protein, an integral membrane protein involved in directed motility of microbes to chemical cues and environment, occurred prior to circumcision, while the filamentous hemagglutinin pathway (a strong immunogenic protein) was depleted after circumcision CONCLUSIONS: Our results offer greater insight into the host-microbiota relationship of penile circumcision and may serve to lay the groundwork for future studies focused on drivers of inflammation, infection, and oncogenesis. "
4.	Starvation 06/01/2005 - "In-frame deletion mutants of homologues of CheW (DeltacheW(3a)and DeltacheW(3b)), CheR (DeltacheR(3)), CheA (DeltacheA(3)) and a methyl-accepting chemotaxis protein (Deltamcp(3)) are defective in starvation-induced formation of heat and desiccation resistant cyst cells. " 02/01/1994 - "DMSO (> 0.1 M) or nutrient depletion triggered a repellent response: cell swarming was inhibited and FrzCD (a methyl-accepting chemotaxis protein) was demethylated; higher concentrations of DMSO (> 0.3 M) or prolonged starvation induced an additional response which involved cellular morphogenesis: DMSO caused cells to convert from rod-shaped vegetative cells to spherical, environmentally resistant "DMSO spores," and starvation induced myxospore formation in the fruiting bodies. "
5.	Malnutrition (Nutritional Deficiencies) 08/23/2023 - "Here, we show that stroke patients have (1) increased Parabacteroides and Escherichia_Shigella, but decreased Prevotella and Fecalibacterium; (2) higher transposase and peptide/nickel transport system substrate-binding protein, but lower RNA polymerase sigma-70 factor and methyl-accepting chemotaxis protein, which are suggestive of malnutrition. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Membrane Proteins (Integral Membrane Proteins)
3.	Hemagglutinins (Hemagglutinin)
4.	Transposases
5.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
6.	Virulence Factors (Pathogenicity Factors)
7.	DNA-Directed RNA Polymerases (RNA Polymerase)
8.	Phosphoric Monoester Hydrolases (Phosphatases)
9.	Phosphates (Orthophosphate)
10.	Peptides (Polypeptides)