Bcl-2-Like Protein 11

A BCL-2-like protein that has a C-terminal BCL-2 homology (BH3) domain and forms heterodimers with other BCL-2 FAMILY PROTEINS. It is a strong inducer of APOPTOSIS and ANOIKIS; several isoforms are expressed (BimEL, Bim L, Bim-alpha, Bim-s; and Bim-gamma) that have different potencies for inducing apoptosis.

Also Known As:

BCL2L11 Protein; BIM Protein; Bcl-2-Binding Protein, BIM; Bcl-2-Interacting Mediator of Cell Death; 11, Bcl-2-Like Protein; BIM Bcl-2-Binding Protein; Bcl 2 Binding Protein, BIM; Bcl 2 Interacting Mediator of Cell Death; Bcl 2 Like Protein 11; Protein 11, Bcl-2-Like; Protein, BCL2L11; Protein, BIM; Protein, BIM Bcl-2-Binding

Networked: 139 relevant articles (0 outcomes, 10 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Strasser, Andreas: 9 articles (01/2016 - 11/2003)
2.	Bouillet, Philippe: 6 articles (09/2012 - 11/2003)
3.	Hersey, Peter: 3 articles (11/2014 - 10/2003)
4.	Adams, Jerry M: 3 articles (07/2011 - 02/2004)
5.	Häcker, Georg: 3 articles (11/2008 - 10/2004)
6.	Kwon, Taeg Kyu: 2 articles (01/2020 - 01/2014)
7.	Min, Kyoung-Jin: 2 articles (01/2020 - 01/2014)
8.	Woo, Seon Min: 2 articles (01/2020 - 01/2014)
9.	Katz, Samuel G: 2 articles (11/2019 - 06/2012)
10.	Gurzov, Esteban N: 2 articles (01/2018 - 12/2011)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 11/01/2016 - "Our data demonstrate that Bim protein expression is significantly inversely correlated with melanoma features that are associated with worse prognosis. " 11/01/2016 - "Bim protein expression was assessed by immunohistochemistry in primary and metastatic melanomas and correlated with clinical and histopathological features. " 11/01/2016 - "We aimed to investigate Bim protein expression in cutaneous melanoma (CM). " 11/01/2016 - "BH3-only protein Bim predicts advanced stage of cutaneous melanoma." 07/10/2013 - "Melanoma cells are characterized by apoptosis deficiency coinciding with reduced expression of the proapoptotic Bcl-2 protein Bim. "
2.	Neoplasms (Cancer) 10/19/2022 - "Signaling pathway analyses revealed that VitD co-treatments triggered cancer cell death by increasing the expression of the pro-apoptotic BCL-2 family protein BIM. " 01/01/2022 - "Expression of this dual binder in a subset of cancer cells induced apoptotic cell death at levels significantly higher than those induced by the pro-apoptotic BIM protein. " 09/01/2019 - "Therefore, we hypothesized that TA activates the JNK pathway to increase the transcription of the proapoptotic protein Bim, thereby inhibiting Bcl-xL and reversing MDR in tumor cells. " 12/19/2017 - "Bcl-2 is often upregulated in cancers to neutralize the BH3-only protein Bim at the mitochondria. " 05/23/2017 - "Conclusions: Overexpression of miR-17-92 gene plays a pivotal role in growth, proliferation, apoptosis and cell cycle of DU145 cells through down-regulation of apoptotic protein BIM and tumor suppressor PTEN and activation of Akt and ERK signaling pathway. "
3.	B-Cell Lymphoma (Lymphoma, B Cell) 01/01/2012 - "The B-cell lymphoma 2 interacting mediator of cell death (Bim) protein was dispensable for proapoptotic response to BITC in MCF-7 and MDA-MB-231 cells as judged by RNA interference studies. " 11/02/2022 - "We showed that silencing PRDX1 led to the loss of B-cell lymphoma 2 (Bcl-2) and activated Bcl-2-like protein 11 (Bim) which further induced Bax activation. " 10/01/2013 - "Bcl-2-interacting mediator of cell death (Bim) is a pro-apoptotic B-cell lymphoma 2 family member implicated in numerous apoptotic stimuli. " 09/19/2019 - "Ovotransferrin induced apoptosis of matured osteoclasts, accompanied by increased expression of Bcl-2-like protein 11 (Bim) and Bcl-2-assoicated death promoter (Bad), but decreased expression of B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma-extra-large (Bcl-xl). " 09/24/2015 - "Although lowering the levels of the antiapoptotic B-cell lymphoma (BCL)2 family proteins, BA treatment induces the proapoptotic protein BIM and exerts dose-dependent lethality against cultured and primary MCL cells. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2013 - "Further studies showed that silencing of the PERK gene with siRNA attenuated VacA-mediated phosphorylation of eIF2-alpha, CHOP induction, expression of BH3-only protein Bim and Bax activation, and cell death induced by VacA with ammonium chloride, indicating that ER stress may lead to mitochondrial dysfunction during VacA-induced toxicity. " 11/01/2014 - "FoxO proteins' nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells." 11/01/2014 - "FoxO transcription factors effectively heightened BH3-only protein Bim expression, which in turn, being a direct activator of proapoptotic protein Bax, altered Bax/Bcl-2 ratio, culminating into mitochondrial dysfunction, caspases activation, and DNA fragmentation. " 12/01/2019 - "Accumulating pre-clinical evidence shows that miR-124 may act through calpain 1/p25/cyclin-dependent kinases 5 (CDK5), nuclear factor-kappa B (NF-κB), signal transducer and activator of transcription 3 (STAT3), Bcl-2-interacting mediator of cell death (Bim), 5' adenosine monophosphate-activated protein kinase (AMPK) and extracellular signal-regulated kinase (ERK)-mediated pathways to regulate cell survival, apoptosis, autophagy, mitochondrial dysfunction, oxidative damage and neuroinflammation in PD. "
5.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2017 - "Several studies have shown that the antiapoptotic proteins Bcl-xL and Mcl-1, as well as the proapoptotic protein Bim, are key elements to be modulated to kill ovarian cancer cells. " 06/24/2011 - "Here we show that degradation of the Bcl-2 homology 3-only proapoptotic protein Bim plays an important role in cisplatin resistance in ovarian cancer. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	ErbB Receptors (EGF Receptor)
3.	Small Interfering RNA (siRNA)
4.	Transforming Growth Factor beta (TGF-beta)
5.	Simvastatin (Zocor)
6.	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)
7.	Ammonium Chloride (Sal Ammoniac)
8.	Gefitinib (Iressa)
9.	phenoxodiol
10.	nitroxoline

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)