Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.

Also Known As:

SHIP Phosphatases; Src Homology 2 Domain-Containing Inositol Phosphatases; Phosphatases, SHIP; Src Homology 2 Domain Containing Inositol Phosphatases

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Monoester Hydrolases: 7477
        Phosphoinositide Phosphatases: 50
        Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases: 4
        human INPP5D protein
        human INPPL1 protein
        mouse Inpp5d protein
        mouse Inppl1 protein
        rat Inppl1 protein
        zebrafish inpp5d protein
        zebrafish inppl1a protein

Experts

1.	Green, Julie M: 1 article (11/2012)
2.	Huttenlocher, Anna: 1 article (11/2012)
3.	Lam, Pui-ying: 1 article (11/2012)
4.	Yoo, Sa Kan: 1 article (11/2012)
5.	Cheng, Jing: 1 article (10/2012)
6.	DeFrances, Marie C: 1 article (10/2012)
7.	Debelius, Daniel R: 1 article (10/2012)
8.	Kane, Lawrence P: 1 article (10/2012)
9.	Anzelon-Mills, Amy N: 1 article (10/2010)
10.	Bolland, Silvia: 1 article (10/2010)

Related Diseases

1.	Leukemia 10/01/2001 - "A third functional tyrosine-based inhibitory motif, one that fails to bind the SHP-1, SHP-2, and SHIP phosphatases, was identified in parallel studies of FcepsilonRI-bearing rat basophilic leukemia (RBL) cells transfected with constructs having mutations in the PIR-B cytoplasmic region. "
2.	B-Cell Lymphoma (Lymphoma, B Cell) 10/25/2010 - "Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases."
3.	Wounds and Injuries (Trauma) 11/01/2012 - "Depletion of SHIP phosphatases using morpholino oligonucleotides led to increased neutrophil 3D motility and neutrophil infiltration into wounds. "
4.	Neoplasms (Cancer) 10/01/2012 - "Several negative regulators of this pathway have already been described and characterized: the lipid phosphatases SHIP, inositol polyphosphate-4-phosphatase, type II (INPP4B), and phosphatase and tensin homolog (PTEN), the latter of which are tumor suppressors. "
5.	Inflammation (Inflammations) 11/01/2012 - "Taken together, our findings suggest that SHIP phosphatases control neutrophil inflammation by limiting neutrophil motility in vivo."

Related Drugs and Biologics

1.	Tyrosine (L-Tyrosine)
2.	Morpholinos
3.	Phosphoric Monoester Hydrolases (Phosphatases)
4.	Lipids
5.	Inositol (Myoinositol)
6.	Tensins