Tumor Protein p73

A homolog of p53 TUMOR SUPPRESSOR PROTEIN that encodes full-length trans-activating and N-terminally-truncated (DeltaN) isoforms. Detection of splice variants and isoforms in the nervous system (human TELENCEPHALON, CHOROID PLEXUS; CEREBROSPINAL FLUID), embryonic tissue, human BREAST CANCER; OVARIAN CANCER, suggest roles in cellular differentiation.

Also Known As:

Protein p73; TP73 Protein; Tap73 Protein, Human; Tumor Suppressor Protein p73; p73 Protein; p73-alpha; p73-beta; Human Tap73 Protein; Protein p73, Tumor; Protein, Human Tap73; Protein, TP73; Protein, p73; p73 alpha; p73 beta; p73, Protein; p73, Tumor Protein

Networked: 103 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sterba, Jaroslav: 4 articles (09/2015 - 12/2007)
2.	Zitterbart, Karel: 4 articles (09/2015 - 12/2007)
3.	Sznarkowska, Alicja: 3 articles (01/2018 - 02/2010)
4.	Zawacka-Pankau, Joanna: 3 articles (01/2018 - 02/2010)
5.	Sun, Xiao-Feng: 3 articles (07/2006 - 01/2002)
6.	Melino, Gerry: 2 articles (12/2020 - 07/2007)
7.	Kawiak, Anna: 2 articles (01/2018 - 02/2010)
8.	Kostecka, Anna: 2 articles (01/2018 - 02/2010)
9.	Aloe, L: 2 articles (01/2017 - 03/2007)
10.	Neradil, Jakub: 2 articles (09/2015 - 01/2013)

Related Diseases

1.	Neoplasms (Cancer) 08/30/2002 - "To study the biological role of p73 alpha, a member of the p53 tumor suppressor family, we performed a yeast two-hybrid screen of a human cDNA library. " 01/01/2022 - "Tumor protein P73 (TP73) plays an integral role in a wide range of human malignancies, but its gene expression profile, prognostic value, and potential mechanisms in HNSC remain to be comprehensively explored. " 01/01/2022 - "Sporadic TP53 mutations are related to almost half of global cancers since p53 in addition to p73 protein represent essential players in anticancer cellular protection. " 04/15/2021 - "Targeting Post-Translational Modifications of the p73 Protein: A Promising Therapeutic Strategy for Tumors." 09/22/2020 - "Presently, the endeavors focus on reactivating p53 exclusively, neglecting the potential of the restoration of p73 protein for cancer eradication. "
2.	Carcinogenesis 12/01/2004 - "The present study shows that p73 protein is likely to play important roles in skin differentiation rather than proliferation or carcinogenesis of the skin." 04/24/2008 - "We previously showed that loss of p73 protein expression associates with malignant conversion in vivo and ionizing radiation (IR) resistance in vitro in a clonal model of mouse epidermal carcinogenesis. " 01/15/2006 - "The p53-related p73 protein is an important mediator of apoptosis, development and tumorigenesis. " 09/01/2002 - "Immunohistochemical demonstration of p73 protein in the early stages of DMBA-induced squamous-cell carcinogenesis in hamster buccal pouch." 12/01/2007 - "Our results indicate the involvement of p73 protein in MB tumorigenesis and define TP73 as a potential prognostic and therapeutic target for medulloblastoma."
3.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/23/2017 - "The aim of this study was to investigate the tumor protein p73 (TP73) G4C14-A4T14 polymorphism and to perform a meta-analysis to assess TP73 expression in cervical cancer and precancerous tissue. " 01/01/2019 - "Owing to the lack of reports on the correlation between TP73 protein expression and clinicopathologic features of cervical cancer, the aim of our research was to explore the clinical and prognostic significance of TP73 protein expression in cervical cancer patients. " 02/01/2006 - "Ad-p73, but not Ad-p53 (p53 adenovirus), inhibited the growth in vitro of three different HPV positive cervical cancer cell lines, HeLa, ME180, and SiHa, efficiently, which correlated with stable expression of functional p73 protein. " 02/01/2006 - "Therapeutic potential of an adenovirus expressing p73 beta, a p53 homologue, against human papilloma virus positive cervical cancer in vitro and in vivo." 03/15/2008 - "p73 protein expression correlates with radiation-induced apoptosis in the lack of p53 response to radiation therapy for cervical cancer."
4.	Medulloblastoma 12/01/2007 - "Our results indicate the involvement of p73 protein in MB tumorigenesis and define TP73 as a potential prognostic and therapeutic target for medulloblastoma." 03/01/2007 - "The aim of our study was to investigate the role of nerve growth factor (NGF) on the expression of the p73 protein in human ependymoblastoma (EP) and medulloblastoma (MB) cells. " 10/01/2010 - "Our results provide a basis for future studies on the causes and function of distinct intracellular localization of p73 protein isoforms with respect to different protein-protein interactions in medulloblastoma cells."
5.	Carcinoma (Carcinomatosis) 10/01/2008 - "To study the clinical significance of the expression of p53, p63 and p73 protein and the correlation of p53 and p63 in nasal and paranasal sinus carcinoma (NPSC). " 07/07/1999 - "By immunohistochemistry, we detected p73 protein in 61 (32%) of the 193 carcinomas examined. " 06/01/1999 - "Immunostaining of p73 protein was detected in 17/41 carcinomas examined (41%). " 01/01/2012 - "Most of ovarian epithelial tumors express p73 protein with mean values higher in ovarian carcinomas than those in the borderline and benign tumors. " 12/01/2005 - "p73 protein and PCNA protein in LSCC shows stronger expression than that in adjacency carcinoma, which is statistically significant (P <0.05). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Protein Isoforms (Isoforms)
3.	DNA (Deoxyribonucleic Acid)
4.	Nerve Growth Factor (NGF)
5.	Paraffin
6.	dehydroleucodine
7.	benz(a)anthracene (benzanthracene)
8.	Messenger RNA (mRNA)
9.	Transcription Factors (Transcription Factor)
10.	Cyclin-Dependent Kinase Inhibitor p15

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Radiotherapy