Patched-2 Receptor

A patched receptor that may function redundantly with the PATCHED-1 RECEPTOR to modulate hedgehog signaling. It may also play a role in epidermal development and as a TUMOR SUPPRESSOR PROTEIN. Mutations in the patched-2 gene are associated with BASAL CELL NEVUS SYNDROME; CARCINOMA, BASAL CELL; and MEDULLOBLASTOMA.

Also Known As:

PTCH2 Protein; Patched Homolog-2; Patched Receptor-2; Patched-2 Protein; Patched 2 Protein; Patched 2 Receptor; Patched Homolog 2; Patched Receptor 2; Receptor, Patched-2

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Patched Receptors: 58
        Patched-2 Receptor: 3
        human PTCH2 protein
        mouse Ptch2 protein
  - Neoplasm Proteins: 2
    - Tumor Suppressor Proteins: 1683
      - Patched Receptors: 58
        Patched-2 Receptor: 3
        human PTCH2 protein
        mouse Ptch2 protein

Experts

1.	Bieber, Marcia: 1 article (08/2011)
2.	He, Biao: 1 article (08/2011)
3.	Jablons, David: 1 article (08/2011)
4.	Schmid, Seraina: 1 article (08/2011)
5.	Teng, Nelson N H: 1 article (08/2011)
6.	Zhang, Fang: 1 article (08/2011)
7.	Zhang, Mallory: 1 article (08/2011)
8.	Dolf, G: 1 article (07/2008)
9.	Drögemüller, C: 1 article (07/2008)
10.	Leeb, T: 1 article (07/2008)

Related Diseases

1.	T-Cell Leukemia (Leukemia, T Cell) 04/01/2006 - "Pair-wise comparisons suggested that some genes (zinc finger protein 350 [ZNF350], solute carrier family 1, member 6 [SLC1A6], F-box protein 7 [FBX07] and vacuole 14 protein homolog [VAC14]) distinguished most classes of fatigued subjects from healthy subjects, whereas others (patched homolog 2 [PTCH2] and T-cell leukemia/lymphoma [TCL1A]) differentiated specific fatigue classes. "
2.	Ovarian Neoplasms (Ovarian Cancer) 08/01/2011 - "Using real-time polymerase chain reaction, we studied 16 primary grade 3 International Federation of Gynecology and Obstetrics stage III serous ovarian cancer samples for expression of the Wnt pathway gene AXIN2, fibroblast growth factor 9, and Hh pathway gene expressions of glioma-associated oncogene 1, glioma-associated oncogene 2, patched homolog 1, patched homolog 2, Indian Hedgehog (HH), sonic HH, and Smoothened, a G protein-coupled receptor protein. "
3.	Neoplasms (Cancer) 08/01/2011 - "More than half of the tumor samples showed involvement of Hh signaling or pathway activation either by expression of transcription factors and Hh ligands or by overexpression of Indian HH/sonic HH and the receptor-encoding patched homolog 1/patched homolog 2. We found a wide variation in fold expression of genes involved in the Wnt and Hh pathway between patient samples."
4.	Lymphoma (Lymphomas) 04/01/2006 - "Pair-wise comparisons suggested that some genes (zinc finger protein 350 [ZNF350], solute carrier family 1, member 6 [SLC1A6], F-box protein 7 [FBX07] and vacuole 14 protein homolog [VAC14]) distinguished most classes of fatigued subjects from healthy subjects, whereas others (patched homolog 2 [PTCH2] and T-cell leukemia/lymphoma [TCL1A]) differentiated specific fatigue classes. "
5.	Glioma (Gliomas) 08/01/2011 - "Using real-time polymerase chain reaction, we studied 16 primary grade 3 International Federation of Gynecology and Obstetrics stage III serous ovarian cancer samples for expression of the Wnt pathway gene AXIN2, fibroblast growth factor 9, and Hh pathway gene expressions of glioma-associated oncogene 1, glioma-associated oncogene 2, patched homolog 1, patched homolog 2, Indian Hedgehog (HH), sonic HH, and Smoothened, a G protein-coupled receptor protein. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Fibroblast Growth Factor 9
3.	F-Box Proteins
4.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
5.	Transcription Factors (Transcription Factor)
6.	Ligands
7.	Patched-1 Receptor