Patched-1 Receptor

A patched receptor for several HEDGEHOG PROTEINS that associates with the SMOOTHENED RECEPTOR to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN; mutations in the patched-1 gene are associated with BASAL CELL NEVUS SYNDROME; SQUAMOUS CELL CARCNIOMA of the ESOPHAGUS; trichoepitheliomas, and CARCINOMA, TRANSITIONAL CELL of the URINARY BLADDER.

Also Known As:

Networked: 50 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jeng, Kuo-Shyang: 3 articles (02/2013 - 01/2013)
2.	Jeng, Wen-Juei: 3 articles (02/2013 - 01/2013)
3.	Sheen, I-Shyan: 3 articles (02/2013 - 01/2013)
4.	Yu, Ming-Che: 3 articles (02/2013 - 01/2013)
5.	Chen, Feng: 2 articles (01/2016 - 01/2015)
6.	Hong, Yingying: 2 articles (01/2016 - 01/2015)
7.	Li, Tiejun: 2 articles (01/2016 - 01/2015)
8.	Li, Xuefen: 2 articles (01/2016 - 01/2015)
9.	Qu, Jiafei: 2 articles (01/2016 - 01/2015)
10.	Zhang, Heyu: 2 articles (01/2016 - 01/2015)

Related Diseases

1.	Basal Cell Nevus Syndrome (Gorlin Syndrome) 01/01/2016 - "This study indicates that germline PTCH1 heterozygous mutations play a major role in bone metabolism in patients with NBCCS, in particular in those with PTCH1 protein truncation mutations. " 08/01/2012 - "Mutations in the Patched homolog 1 (PTCH1) gene lead to an autosomal dominant disorder known as nevoid basal cell carcinoma syndrome (NBCCS) or Gorlin syndrome (GS). " 08/01/2012 - "Patched homolog 1 gene mutation (p.G1093R) induces nevoid basal cell carcinoma syndrome and non-syndromic keratocystic odontogenic tumors: A case report." 07/01/2012 - "These results clearly demonstrate that a selective haploinsufficiency of longer isoforms of the PTCH1 protein, PTCHL and PTCHM, but not PTCHS is sufficient to cause NBCCS. " 07/01/2012 - "Selective haploinsufficiency of longer isoforms of PTCH1 protein can cause nevoid basal cell carcinoma syndrome."
2.	Neoplasms (Cancer) 01/01/2017 - "Mice heterozygous for patched homolog 1 mutations, like heterozygous patched 1 humans, have a higher incidence of Shh subgroup medulloblastoma (MB) and other tumors. " 01/15/2013 - "Patched homolog 1 (PTCH1) is a known tumor suppressor that regulates the Hedgehog (Hh) pathway and has been implicated in tumorigenesis. " 01/01/2023 - "The patched/hedgehog intracellular signaling pathway is responsible for regulating cell growth and tumor formation by inactivating mutation of protein patched homolog 1 (PTCH1) or activating mutation of Smoothened (SMOm). " 12/01/2017 - "Tumor-associated astrocytes (TAA) secrete the ligand sonic hedgehog (Shh), which is required for maintaining MB cell proliferation despite the absence of its primary receptor Patched-1 (Ptch1). " 05/28/2010 - "This result was consistent with a dose-dependent reduction of the protein levels of antiapoptotic BCL-2 and the tumor suppressor patched 1 protein (PTCH). "
3.	Basal Cell Carcinoma (Rodent Ulcer) 01/01/2019 - "Evaluation of Patched-1 Protein Expression Level in Low Risk and High Risk Basal Cell Carcinoma Subtypes." 06/01/2011 - "For example, hedgehog pathway studies of mutations in the patched homolog 1 (PTCH1) gene, which constitutively activates Smoothened (SMO), led to development of an oral SMO inhibitor active in advanced basal cell carcinoma and which, in very high-risk Gorlin syndrome patients (germ line PTCH1 mutation), is nearly completely clinically effective in intercepting basal cell neoplasia. "
4.	Infections 04/12/2009 - "Using an improved discovery technology, Random Homozygous Gene Perturbation (RHGP), we identified the PTCH1 protein as an essential host target that critically controls influenza virus infection. "
5.	Glioma (Gliomas) 01/01/2016 - "In case of the Hh pathway, EGCG/TF could also reduce expressions of glioma-associated oncogene homolog 1 (Gli1) and SMO (smoothened homolog) along with up-regulation of PTCH1 (patched homolog 1). " 01/01/2013 - "To study the activation of the Shh pathway, we examined the mRNA expressions of Shh, patched homolog 1 (Ptch-1), glioma-associated oncogene homolog 1 (Gli-1), and smoothened homolog (Smoh) by real-time polymerase chain reaction of both CD133+ and CD133- cells. " 06/01/2021 - "Are glioma-associated oncogene homolog 1, 2, and 3 (GLI1, 2, and 3) and protein patched homolog 1 (PTCH1) specific markers for precursor theca cells in human ovaries as in mouse ovaries? " 12/10/2020 - "Hedgehog signaling pathway was then found to be suppressed by Jer, as proved by the decreased expression of Sonic Hedgehog (Shh), Hedgehog receptor protein patched homolog 1 (PTCH1), smoothened (SMO) and glioma-associated oncogene homolog 1 (Gli1) in NSCLC cells. " 09/01/2019 - "The placental expression levels of surrogate markers of the SHH pathway, patched homolog 1 (PTCH1) and glioma-associated oncogene homolog (GLI) 2, were evaluated using quantitative real-time PCR, western blot analysis, and immunohistochemistry. "

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6.	beta Catenin
7.	TRPC Cation Channels
8.	Intercellular Signaling Peptides and Proteins (Growth Factors)
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10.	Guanine Nucleotides

Related Therapies and Procedures

1.	Therapeutics