Transcription Factor HES-1

A basic-helix-loop-helix transcription factor that functions as a transcriptional repressor for genes transcribed by bHLH proteins. For example, it may negatively regulate MYOGENESIS by inhibiting MyoD1 and ASH1 proteins. It is also required for the stability of FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS and their localization to the cell nucleus in response to DNA DAMAGE.

Also Known As:

Hairy and Enhancer of Split 1 Protein; Hairy-Like Transcription Factor; HES-1, Transcription Factor; Hairy Like Transcription Factor; Transcription Factor HES 1; Transcription Factor, Hairy-Like

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Basic Helix-Loop-Helix Transcription Factors: 510
      - Transcription Factor HES-1: 2
        human HES1 protein
        mouse Hes1 protein
        rat Hes1 protein
        Xenopus hes1 protein
  - DNA-Binding Proteins: 2009
    - Basic Helix-Loop-Helix Transcription Factors: 510
      - Transcription Factor HES-1: 2
        human HES1 protein
        mouse Hes1 protein
        rat Hes1 protein
        Xenopus hes1 protein

Experts

1.	Kerezoudis, Np: 1 article (07/2010)
2.	Kiaris, H: 1 article (07/2010)
3.	Meliou, E: 1 article (07/2010)
4.	Tosios, Ki: 1 article (07/2010)

Related Diseases

1.	Radicular Cyst 07/27/2010 - "In this immunohistochemical study we have examined the expression of the receptor Notch 1, the ligand Delta 1 and the transcription factor HES 1 in the epithelium of well defined periapical cysts. "
2.	Paucibacillary Leprosy 02/01/2023 - "Transcription Factor HES-1: How Is the Expression of This Transcriptional Factor in Paucibacillary Leprosy Patients?"

Related Drugs and Biologics

1.	Notch Receptors
2.	Ligands