Apolipoprotein A-V

A minor apolipoprotein that associates with HIGH-DENSITY LIPOPROTEINS (HDL), VERY-LOW-DENSITY LIPOPROTEINS (VLDL), and CHYLOMICRONS. It regulates levels of plasma TRIGLYCERIDES by activating APOLIPOPROTEIN C-II LIPOPROTEIN LIPASE and inhibiting hepatic VLDL triglyceride hydrolysis.

Also Known As:

APOA5 Protein; Apo A-V Protein; Apo A5 Protein; ApoA-V Protein; Apolipoprotein A5; Apo A V Protein; ApoA V Protein; Apolipoprotein A V

Networked: 193 relevant articles (4 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lee, Jong Ho: 9 articles (08/2015 - 10/2004)
2.	Melegh, Béla: 7 articles (06/2011 - 01/2006)
3.	Li, Rong: 6 articles (06/2022 - 01/2016)
4.	Kisfali, Péter: 6 articles (06/2011 - 01/2007)
5.	Maász, Anita: 6 articles (06/2011 - 01/2006)
6.	Ordovas, Jose M: 6 articles (12/2009 - 10/2004)
7.	Dai, Wen: 5 articles (09/2021 - 01/2017)
8.	Kao, Jau-Tsuen: 5 articles (01/2018 - 10/2003)
9.	Chae, Jey Sook: 5 articles (08/2015 - 04/2009)
10.	Jang, Yangsoo: 5 articles (07/2012 - 10/2004)

Related Diseases

1.	Hypertriglyceridemia 08/15/2006 - "We apply the proposed method to the hypertriglyceridemia study and identifies 3 haplotypes in the apolipoprotein A5 gene that are associated with increased risk for hypertriglyceridemia. " 02/01/2006 - "We applied the proposed approach to study the association between hypertriglyceridemia and the apolipoprotein A5 gene. " 08/01/2013 - "Mutations in apolipoprotein A5 (APOA5) have been associated with hypertriglyceridemia in humans and mice. " 12/01/2011 - "Resequencing the apolipoprotein A5 (APOA5) gene in patients with various forms of hypertriglyceridemia." 10/01/2010 - "Hypertriglyceridemia in obese subjects: caused by reduced apolipoprotein A5 plasma levels?"
2.	Obesity 01/01/2020 - "Apolipoprotein A5 (ApoA5) has been shown to influence the prevalence and pathogenesis of obesity. " 08/01/2013 - "Apolipoprotein A5 deficiency aggravates high-fat diet-induced obesity due to impaired central regulation of food intake." 03/01/2019 - "The association of risk allele C of genetic variant rs662799 of Apolipoprotein A5 gene with dyslipidaemia and obesity may lead to the development of metabolic syndrome in the Pakistan adult population." 09/01/2013 - "Apolipoprotein A-V level may contribute to the development of obesity-associated dyslipidemia." 05/01/2013 - "The role of apolipoprotein A5 in obesity and the metabolic syndrome."
3.	Chronic Kidney Failure (Chronic Renal Failure) 04/01/2007 - "Marked decrease of apolipoprotein A-V in both diabetic and nondiabetic patients with end-stage renal disease." 01/01/2022 - "Apolipoprotein A5 gene polymorphism (rs662799) and cardiovascular disease in end-stage kidney disease patients."
4.	Pulmonary Hypertension 08/08/2022 - "Apolipoprotein A5 ameliorates MCT induced pulmonary hypertension by inhibiting ER stress in a GRP78 dependent mechanism."
5.	Body Weight (Weight, Body) 04/01/2009 - "Overexpression of apolipoprotein A5 in mice is not protective against body weight gain and aberrant glucose homeostasis."

Related Drugs and Biologics

1.	Metformin (Glucophage)
2.	Glucose (Dextrose)
3.	Endoplasmic Reticulum Chaperone BiP
4.	Triglycerides (Triacylglycerol)
5.	Lipids
6.	Apolipoproteins
7.	Lipoproteins (Lipoprotein)
8.	Apolipoproteins A
9.	Proteins (Proteins, Gene)
10.	HDL Cholesterol

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Injections