Membrane glycosylphosphatidylinositol-anchored glycoproteins that may aggregate into rod-like structures. The prion protein (PRNP) gene is characterized by five TANDEM REPEAT SEQUENCES that encode a highly unstable protein region of five octapeptide repeats. Mutations in the repeat region and elsewhere in this gene are associated with CREUTZFELDT-JAKOB DISEASE; FATAL FAMILIAL INSOMNIA; GERSTMANN-STRAUSSLER DISEASE; Huntington disease-like 1, and KURU.
Also Known As:
AltPrP; Alternative Prion Protein; CD230 Antigen; Creutzfeldt-Jakob Disease Protein; Fatal Familial Insomnia Protein; Major Prion Protein; Prion Protein; Antigen, CD230; Creutzfeldt Jakob Disease Protein; Prion Protein, Alternative; Prion Protein, Major; PrP Proteins