S100 Calcium-Binding Protein A4

An S100 protein characterized by four helix bundles that form N- and C-terminal EF HAND MOTIFS. It functions as a homodimer and interacts with both intracellular and extracellular signaling proteins. Aberrant S100A4 activity is associated with NEOPLASM METASTASIS; FIBROSIS; and RHEUMATOID ARTHRITIS.

Also Known As:

Networked: 188 relevant articles (0 outcomes, 19 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Grigorian, Mariam: 13 articles (01/2019 - 04/2004)
2.	Ambartsumian, Noona: 12 articles (01/2019 - 04/2004)
3.	Lukanidin, Eugene: 10 articles (02/2015 - 04/2004)
4.	Klingelhöfer, Jörg: 8 articles (01/2019 - 06/2004)
5.	Grigorian, M: 6 articles (11/2008 - 12/2000)
6.	Lukanidin, E: 5 articles (12/2006 - 12/2000)
7.	Yang, Tao: 4 articles (03/2022 - 10/2014)
8.	Georgieva, S G: 4 articles (05/2019 - 03/2016)
9.	Pankratova, E V: 4 articles (05/2019 - 03/2016)
10.	Portseva, T N: 4 articles (05/2019 - 03/2016)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2018 - "The purpose of this study was to characterize the cellular localization of the S100A4 protein in MCs of human tissues with inflammatory or tumor disorders and, to determine the consequence of reducing its expression in MC response. " 01/01/2018 - "Cytoplasmic expression of S100A4 protein was demonstrated in the tumor tissue of 132 patients (89.2%) out of a total of 148 study patients. " 08/01/2008 - "In this study we applied KOC and S100A4 protein immunocytochemistry to assess their potential use as adjunct markers in differentiating benign from malignant cells, and improve the diagnostic sensitivity of this method for pancreatobiliary malignancies. " 05/01/2007 - "Further studies of the implications of these interactions in different molecular pathways may shed additional light on the role of S100A4 protein in the control of tumor cell motility and migration. " 06/16/2003 - "The S100A4 protein has been associated with increased metastatic capacity of cancer cells, and recent studies have suggested a correlation between the expression level of S100A4 and the prognostic outcome for patients with various types of cancer. "
2.	Breast Neoplasms (Breast Cancer) 03/01/2019 - "The results of the study show that the ability of breast cancer cells to migrate depends on the S100A4 protein concentration in the cell." 09/05/2008 - "The purpose of the study was to determine the expression of S100A4 protein in the invasion status and metastatic potential of breast cancer by using tissue microarray and to determine its role in breast cancer based on the expression of S100A4 gene product. " 01/01/2023 - "Specifically, STC1 upregulates the expression of S100 calcium-binding protein A4 (S100A4) by facilitating the phosphorylation of EGFR and ERK signaling in breast cancer cells. " 03/01/2019 - "The Expression Level of S100A4 Protein Affects the Migration Activity of Breast Cancer Cells." 09/05/2008 - "S100A4 protein expression appears widely expressed in early and advanced breast cancer stages compared with normal breast. "
3.	Neoplasm Metastasis (Metastasis) 06/01/2023 - "S100 calcium binding protein A4 (S100A4), which promotes metastasis, have recently been discovered as an effective inflammatory factor and elevated in bronchoalveolar lavage fluid in asthmatic mice. " 01/01/2018 - " The S100 calcium binding protein A4 (S100A4) predicts metastasis formation and reduced CRC patient survival. " 03/28/2017 - "The S100 calcium-binding protein A4 (S100A4) induces epithelial mesenchymal transition, migration, invasion, angiogenesis and metastasis. " 08/01/2015 - "We demonstrate our approach by studying the mechanism of metastasis promotion by the S100A4 protein, and suggest therapeutic strategies. " 04/01/2013 - "S100 calcium binding protein A4 (S100A4) is directly involved in tumour metastasis. "
4.	Stomach Neoplasms (Stomach Cancer) 11/01/2018 - "Our study demonstrated that IL-1β promote the nuclear translocation of S100A4 protein in gastric cancer cells MGC803, which are PI3K dependent, suggesting the existence of IL-1β-PI3K-S100A4 pathway for the first time. " 11/01/2018 - "We speculate that IL-1β might promote the nuclear translocation of S100A4 protein in MGC803 gastric cancer cells and therefore enhance their stem-like properties. " 11/01/2018 - "IL-1β promotes the nuclear translocaiton of S100A4 protein in gastric cancer cells MGC803 and the cell's stem-like properties through PI3K pathway." 09/01/2007 - "S100A4 protein expression was also determined by immunohistochemical method in 131 samples of gastric cancer and 20 samples of matched metastatic lymph nodes. " 01/01/2010 - "The present study investigated the clinical significance of S100 calcium binding protein A4 in the development, progression, and metastasis of gastric cancer. "
5.	Colorectal Neoplasms (Colorectal Cancer) 08/01/2003 - "The aim of the present study was to analyse the expression of the S100A4 protein in colorectal cancer. " 10/02/2019 - "By microarray profiling of HMGA2-driven gene signature and subsequent Connectivity Map (CMap) database mining, we identified that S100 calcium-binding protein A4 (S100A4) may be a druggable vulnerability for HMGA2-overexpressing colorectal cancer. " 02/01/2015 - "Moreover, PX-12 decreased S100A4 protein expression in the colorectal cancer cells. " 02/01/2012 - "A total of 526 colorectal cancer patients were examined for S100A4 protein by immunohistochemistry using tissue microarrays. " 07/01/2009 - "Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer."

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