Checkpoint Kinase 1

A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle.

Also Known As:

Networked: 311 relevant articles (7 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Karnitz, Larry M: 6 articles (01/2022 - 07/2005)
2.	Morgan, Meredith A: 6 articles (03/2014 - 01/2009)
3.	Lin, Aimee Bence: 5 articles (11/2021 - 01/2016)
4.	Singh, Shivendra V: 5 articles (11/2019 - 08/2005)
5.	Hynes, Scott: 4 articles (11/2021 - 01/2016)
6.	Schwartz, Gary K: 4 articles (09/2014 - 04/2007)
7.	Lawrence, Theodore S: 4 articles (08/2013 - 01/2009)
8.	Maybaum, Jonathan: 4 articles (08/2013 - 01/2009)
9.	Parsels, Joshua D: 4 articles (08/2013 - 01/2009)
10.	Parsels, Leslie A: 4 articles (08/2013 - 01/2009)

Related Diseases

1.	Neoplasms (Cancer) 11/18/2010 - "Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents." 01/01/2023 - "Checkpoint kinase 1 (Chk1) inhibition selectively disrupts homologous recombination (HR)-mediated DNA repair and confers synthetic lethality in p53-deficient tumors, we therefore aim at expounding the chemopotentiating effects of Chk1 inhibition on PARPi in BRCA-proficient and p53-deficient cancer cells. " 01/01/2023 - "Retraction Notice to: Selective Targeting of Checkpoint Kinase 1 in Tumor Cells with a Novel Potent Oncolytic Adenovirus." 10/28/2021 - "Checkpoint kinase 1 (CHK1) plays an important role in the DNA damage response pathway, being a potential anti-cancer drug target. " 01/01/2021 - "Checkpoint kinase 1 (CHK1) plays a broad role in regulating the cell cycle process and is involved in the pathogenesis of various malignant tumors. "
2.	Ataxia Telangiectasia (Louis Bar Syndrome) 04/01/2012 - "Previous studies have demonstrated that inhibition of the ataxia telangiectasia and Rad3-related (ATR) and checkpoint kinase 1 (Chk1) pathway in p53-deficient cells can induce such a synthetic lethal outcome. " 11/01/2011 - "The aim of this study was to identify an inhibitor of the G(2) checkpoint including the ataxia-telangiectasia-mutated and Rad3-related checkpoint kinase 1 pathway that selectively suppresses the growth of p53-deficient cells. " 01/01/2023 - "The ataxia telangiectasia and Rad3-related (ATR) checkpoint kinase 1 (CHK1) pathway is intricately involved in protecting the integrity of the human genome by suppressing replication stress and repairing DNA damage. " 01/01/2023 - "Mechanistically, the combined treatment induced DNA damage, which elicited the activation of ataxia telangiectasia mutated (ATM)/AMT- and Rad3-related (ATR) checkpoint kinase 1 (Chk1)/Chk2 signal transduction pathways. " 09/01/2021 - "The results showed that 6, 16-19 had remarkable inhibitory effects against five tumor cell lines (A549, HepG2, HeLa, MDA-MB-231, and HCT116) with IC50 values ranging from 6.69-33.46 μM, and showed down-regulating the expression of ATR (ataxia telangiectasia mutated and RAD3-related) and CHK1 (checkpoint kinase 1) levels in HCT116 and A549 cell lines. "
3.	Infections 01/01/2018 - "Together our data show that HSV-1 activates the ATR pathway at early stages of infection and that ATR and Chk1 kinase activities play important roles in HSV-1 replication fitness. " 12/01/2023 - "We have previously shown that infection of cells with gammacoronavirus infectious bronchitis virus (IBV) activated the theataxia-telangiectasia mutated (ATM) Rad3-related (ATR)/checkpoint kinase 1 (Chk1) pathway and induced cell cycle arrest in S and G2/M phases, partially through the interaction of nonstructural protein 13 (nsp13) with the p125 catalytic subunit of DNA polymerase delta (pol δ). " 08/01/2021 - "The network pharmacology analysis suggests saikosaponins interact with the proteins CAT Gene CAT (Catalase) and Checkpoint kinase 1 (CHEK1); both of these enzymes play a major role in cell homeostasis and DNA damage during infection, suggesting a possible improvement in immune response toward COVID-19."
4.	Urinary Bladder Neoplasms (Bladder Cancer) 01/01/2021 - "Inhibition of checkpoint kinase 1 potentiates anticancer activity of gemcitabine in bladder cancer cells." 01/01/2017 - "We therefore explored the efficacy of the combination of gemcitabine and AZD7762, a checkpoint kinase 1/2 (CHK1/2) inhibitor, for bladder cancer. " 01/01/2021 - "DNA damage which was observed through the interaction of 19-BJB with nucleotide chains and affected DNA repair resulted in the activation of checkpoint kinase 1 (Chk1) and checkpoint kinase 2 (Chk2) in bladder cancer cell lines. "
5.	COVID-19 08/01/2021 - "The network pharmacology analysis suggests saikosaponins interact with the proteins CAT Gene CAT (Catalase) and Checkpoint kinase 1 (CHEK1); both of these enzymes play a major role in cell homeostasis and DNA damage during infection, suggesting a possible improvement in immune response toward COVID-19."

Related Drugs and Biologics

1.	Gemcitabine
2.	Proteins (Proteins, Gene)
3.	DNA (Deoxyribonucleic Acid)
4.	Enzymes
5.	3- (carbamoylamino)- 5- (3- fluorophenyl)- N- (3- piperidyl)thiophene- 2- carboxamide
6.	Cyclin-Dependent Kinases (cdk Proteins)
7.	Catalase
8.	rucaparib
9.	saikosaponin D
10.	prexasertib

Related Therapies and Procedures

1.	Therapeutics
2.	Craniospinal Irradiation
3.	Investigational Therapies (Experimental Therapy)
4.	Drug Therapy (Chemotherapy)
5.	Radiotherapy