Stromal Interaction Molecules

Membrane-associated calcium-binding proteins that are characterized by N-terminal EF HAND MOTIFS and a STERILE ALPHA MOTIF. They function as sensors of ENDOPLASMIC RETICULUM calcium levels and translocate from the ER to the plasma membrane to activate CALCIUM CHANNELS in response to intracellular calcium depletion.

Also Known As:

Networked: 31 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Yih-Fung: 3 articles (06/2016 - 09/2011)
2.	Shen, Meng-Ru: 3 articles (06/2016 - 09/2011)
3.	Feske, Stefan: 3 articles (05/2015 - 11/2010)
4.	Castillo-Galán, Sebastián: 2 articles (01/2022 - 01/2022)
5.	Iturriaga, Rodrigo: 2 articles (01/2022 - 01/2022)
6.	Chen, Ying-Ting: 2 articles (04/2013 - 09/2011)
7.	Chiu, Wen-Tai: 2 articles (04/2013 - 09/2011)
8.	Alharbi, Sulaiman Ali: 1 article (01/2022)
9.	Arenas, Germán A: 1 article (01/2022)
10.	Chinnathambi, Arunachalam: 1 article (01/2022)

Related Diseases

1.	Diabetic Nephropathies (Diabetic Nephropathy) 06/01/2019 - "However, there are no studies on the role of stromal interaction molecule (STIM) and its two subtypes, STIM1 and STIM2, in the epithelial-to-mesenchymal transition (EMT) of podocytes induced by diabetic kidney disease (DKD). "
2.	Neoplasms (Cancer) 03/30/2019 - "Stromal-interaction molecules (STIM)-activated Orai channels are major Ca2+ entry channels in cancer cells and immune cells, they are upregulated in many tumors, and they are strongly regulated by ROS. " 04/17/2013 - "A number of known molecular components involved in Ca2+ influx pathways, including stromal interaction molecule (STIM)/Orai-mediated store-operated Ca2+ entry (SOCE) and the Ca2+-permeable transient receptor potential (TRP) channels, have been implicated in cancer cell migration and tumor metastasis. " 08/01/2001 - "STIM1 (where STIM is stromal interaction molecule) is a candidate tumour suppressor gene that maps to human chromosome 11p15.5, a region implicated in a variety of cancers, particularly embryonal rhabdomyosarcoma. " 01/01/2022 - "SOCs including stromal interaction molecules (STIM) and ORAI proteins have been implicated in tumor growth, progression, and metastasis. " 01/01/2021 - "Store-operated Ca2+ entry (SOCE), which is mediated by stromal interaction molecules (STIM) and ORAI proteins, has been implicated in the tumor invasion-metastasis cascade. "
3.	Neoplasm Metastasis (Metastasis) 04/17/2013 - "A number of known molecular components involved in Ca2+ influx pathways, including stromal interaction molecule (STIM)/Orai-mediated store-operated Ca2+ entry (SOCE) and the Ca2+-permeable transient receptor potential (TRP) channels, have been implicated in cancer cell migration and tumor metastasis. " 01/01/2022 - "SOCs including stromal interaction molecules (STIM) and ORAI proteins have been implicated in tumor growth, progression, and metastasis. " 01/01/2021 - "Store-operated Ca2+ entry (SOCE), which is mediated by stromal interaction molecules (STIM) and ORAI proteins, has been implicated in the tumor invasion-metastasis cascade. " 06/01/2016 - "Stromal interaction molecules (STIM) and Orai proteins, recently identified as critical constituents of store-operated Ca(2+) entry (SOCE), have been implicated in cancer cell migration and tumor metastasis. "
4.	Inflammation (Inflammations) 02/01/2010 - "Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation." 08/01/2012 - "SOCE involves proteins Orai1 and stromal interaction molecule (STIM)1. We investigated the link between caveolae, SOCE and inflammation in ASM. " 04/01/2012 - "Specific topics include Orai1 expression; Orai1 roles in store-operated calcium entry and ionic currents of store-depleted cells; blockade of Orai1-related signals by Synta 66 and other pharmacology; activation or regulation of Orai1-related signals by physiological substances and compartments; stromal interaction molecules and the relationship of Orai1 to other ion channels, transporters and pumps; transient receptor potential canonical channels and their contribution to store-operated calcium entry; roles of Orai1 in vascular tone, remodelling, thrombus formation and inflammation; and Orai2 and Orai3. "
5.	Pulmonary Hypertension 01/01/2022 - "Rats exposed to CIH develop lung vascular remodeling and pulmonary hypertension, which paralleled the upregulation of stromal interaction molecule (STIM)-activated TRPC-ORAI Ca2+ channels (STOC) in the lung, suggesting that STOC participate in the pulmonary vascular alterations. " 01/01/2022 - "Crucial Role of Stromal Interaction Molecule-Activated TRPC-ORAI Channels in Vascular Remodeling and Pulmonary Hypertension Induced by Intermittent Hypoxia." 01/01/2022 - "Stromal interaction molecule (STIM)-activated transient receptor potential channels (TRPC) and calcium release-activated calcium channel protein (ORAI) channels (STOC) play key roles in the progression of pulmonary hypertension in pre-clinical models of animals subjected to sustained and intermittent hypoxia. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Calcium
3.	Calcium Release Activated Calcium Channels
4.	TOR Serine-Threonine Kinases
5.	Inositol 1,4,5-Trisphosphate Receptors (Inositol Triphosphate Receptor)
6.	Transient Receptor Potential Channels
7.	Butyric Acid (Butanoic Acid)
8.	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)
9.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
10.	Inositol 1,4,5-Trisphosphate

Related Therapies and Procedures

1.	Prostatectomy (Retropubic Prostatectomy)