Tartrate-Resistant Acid Phosphatase

One of several acid phosphatases in humans, other mammals, plants, and a few prokaryotes. The protein fold of tartrate-resistant acid phosphatase (TRAP) resembles that of the catalytic domain of plant purple acid phosphatase and other serine/threonine-protein phosphatases that also contain a metallophosphoesterase domain. One gene produces the various forms which include purple acid phosphatases from spleen and other tissues. Tartrate-resistant acid phosphatase is a biomarker for pathological states in which it is over-expressed. Such conditions include GAUCHER DISEASE; HODGKIN DISEASE; BONE RESORPTION; and NEOPLASM METASTASIS.

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Networked: 1230 relevant articles (25 outcomes, 94 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Janckila, Anthony J: 26 articles (01/2020 - 06/2002)
2.	Chao, Tsu-Yi: 22 articles (03/2019 - 05/2003)
3.	Andersson, Göran: 17 articles (10/2021 - 09/2004)
4.	Yam, Lung T: 17 articles (09/2011 - 06/2002)
5.	Terpos, Evangelos: 14 articles (12/2019 - 01/2003)
6.	Halleen, Jussi M: 13 articles (11/2013 - 06/2002)
7.	Xu, Jiake: 9 articles (01/2021 - 11/2016)
8.	Wu, Yi-Ying: 9 articles (01/2015 - 04/2008)
9.	Väänänen, H Kalervo: 8 articles (05/2008 - 10/2003)
10.	Lång, Pernilla: 7 articles (10/2021 - 03/2008)

Related Diseases

1.	Bone Resorption 07/15/2020 - "In addition, low dose administration of AD-EA improved the deterioration of trabecular bone microarchitecture caused by OVX through the inhibition of bone resorption by TRAcP and CTK. " 01/01/2014 - "In our study, gene knockout mice, RNA interference, western blot, quantitative real-time PCR, tartrate-resistant acid phosphatase (TRAP) staining, pit formation assay, histomorphometry and measurement of serum parameters were employed to investigate the role of TRPV6 in bone homeostasis, osteoclastogenesis and bone resorption. " 01/01/2010 - "Tartrate-resistant acid phosphatase 5b, a good bone resorption marker, was significantly decreased at week 2 of the study. " 01/01/2001 - "After 12 weeks histologic studies of treated animals revealed that osteoclasts were positive for tartrate-resistant acid phosphatase but showed markedly abnormal ultrastructure which prevented successful bone resorption. " 07/31/1992 - "This provides opportunities to develop the use of Type 5 acid phosphatase as a reporter of pathophysiological events and an essential, though not sufficient, role in bone resorption by osteoclasts has been established by such studies."
2.	Neoplasms (Cancer) 01/01/2022 - "This study suggested that tartrate-resistant acid phosphatase 5b may be elevated in younger patients and in cases with fewer pathological secondary changes, regardless of tumor volume." 01/01/2022 - "The correlation between tartrate-resistant acid phosphatase 5b before initial treatment and tumor volume was evaluated. " 01/01/2019 - "The tartrate-resistant acid phosphatase (TRAP/ACP5) correlated with tumor progression in many malignancies. " 01/01/2017 - "This was in line with the induction of the number of tartrate-resistant acid phosphatase (TRAP+ )-stained osteoclasts in an orthotopic model of local tumor growth after CHM1 knockdown, indicating that CHM1-mediated inhibition of osteomimicry might play a role in homing, colonization, and invasion into bone tissues. " 02/18/2014 - "Osteoclasts in tumor sections were also stained for tartrate-resistant acid phosphatase (TRAP). "
3.	Osteoporosis 02/01/2015 - "Tartrate-resistant acid phosphatase (TRAP) is well known as an osteoclast marker; however, a recent study from our group demonstrated enhanced number of TRAP + osteocytes as well as enhanced levels of TRAP located to intracellular vesicles in osteoblasts and osteocytes in experimental osteoporosis in rats. " 01/01/2023 - "Effectiveness of ROMO was better in patients who had severe osteoporosis with low TH BMD, low FN BMD, and high tartrate-resistant acid phosphatase 5b level at ROMO initiation." 02/01/2020 - "Higher levels of BALP and TRACP were both associated with increased risk of osteoporosis and higher BALP/TRACP ratios were associated with lower risk of osteoporosis, but no associations were observed for fracture risk. " 02/01/2020 - "In a prospective study of 1709 women on AIs, two bone turnover markers, BALP and TRACP, and two bone regulatory markers, RANKL and OPG, were measured and examined in relation to risk of osteoporosis and fragility fractures during a median follow-up time of 6.1 years. " 01/01/2018 - "The model was constructed using 3410 tartrate-resistant acid phosphatase 5b (TRACP-5b) serum concentrations and 1146 lumbar spine (L2-L4) BMD values from 306 patients with primary osteoporosis. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2019 - "Tartrate-resistant acid phosphatase (TRAP) staining was performed to reconfirm that osteoclasts increase in vertebrae with spinal metastasis. " 04/23/2010 - "We tested the hypothesis that baseline serum TRACP 5b activity and its interval change are potential prognostic markers of survival in BC patients with bone metastasis. " 05/01/2009 - "We also found an unusually low TRACP-5b/RANKL ratio for patients who have or later developed metastasis. " 05/01/2008 - "Predicted and observed risks of bone metastasis were well correlated when TRACP, ALP, and PSA were combined and bone scan could have been omitted in 70% of patients by assessing these three markers. " 05/01/2008 - "Logistic regression analysis demonstrated that PSA, ALP, and TRACP were significant predictors of bone metastasis. "
5.	Hairy Cell Leukemia 03/01/1996 - "Immunohistochemistry was compared directly to TRAcP cytochemistry in fixed smears from hairy cell leukemia specimens to gauge the level of sensitivity of our improved method. " 03/01/2005 - "The value of tartrate resistant acid phosphatase (TRAP) immunoreactivity in diagnosis of hairy cell leukemia." 06/01/2004 - "Tartrate resistant acid phosphatase (TRAP) staining and scanning electron microscopy of peripheral blood lymphocytes indicated hairy cell leukemia. " 11/01/2001 - "TRACP 5b is considered to be a marker of the osteoclasts and 5a is found in Gaucher's cells, or in the leukocytes of patients with hairy cell leukemia." 05/15/1998 - "In addition, Bryo 1 treatment induced WSU-CLL cells to become CD11c, CD25 and tartrate-resistant acid phosphatase-positive, specific markers for hairy cell leukemia, a disease exquisitely sensitive to 2-CdA. "

Related Drugs and Biologics

1.	Alkaline Phosphatase
2.	Proteins (Proteins, Gene)
3.	Cathepsin K
4.	Tartrate-Resistant Acid Phosphatase
5.	Osteocalcin
6.	Messenger RNA (mRNA)
7.	Protein Isoforms (Isoforms)
8.	Collagen Type I (Type I Collagen)
9.	collagen type I trimeric cross-linked peptide
10.	Ligands

Related Therapies and Procedures

1.	Therapeutics
2.	Ovariectomy (Oophorectomy)
3.	Renal Dialysis (Hemodialysis)
4.	Aftercare (After-Treatment)
5.	Hip Replacement Arthroplasty (Total Hip Replacement)