Protein Deglycase DJ-1

A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.

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Networked: 127 relevant articles (2 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tsuchiya, Benio: 5 articles (05/2022 - 01/2010)
2.	Iwaya, Keiichi: 5 articles (01/2017 - 06/2012)
3.	Kawate, Takahiko: 4 articles (01/2017 - 07/2012)
4.	Kohno, Norio: 4 articles (07/2015 - 06/2012)
5.	Matsubara, Osamu: 4 articles (07/2015 - 06/2012)
6.	Pu, Xiao-Ping: 4 articles (09/2014 - 07/2011)
7.	Heutink, Peter: 3 articles (08/2019 - 01/2003)
8.	Rizzu, Patrizia: 3 articles (08/2019 - 01/2003)
9.	Noguchi, Noriko: 3 articles (03/2018 - 04/2014)
10.	Saito, Yoshiro: 3 articles (03/2018 - 04/2014)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 07/01/2015 - "In order to determine the clinical significance of DJ-1 protein in the sera of breast cancer patients, we examined blood samples from a breast cancer group (n = 180) and a non-cancerous control group (n = 300). " 06/01/2012 - "As we have previously demonstrated that some breast cancer cell lines secrete DJ-1 protein, we examined here whether breast cancer cells secrete DJ-1 protein in vivo. " 06/01/2012 - "High levels of DJ-1 protein in nipple fluid of patients with breast cancer." 05/01/2013 - "This study aimed to determine the association between low DJ-1 protein expression and pathological complete remission (pCR) after neoadjuvant chemotherapy in breast cancer patients. " 05/01/2013 - "DJ-1 protein expression as a predictor of pathological complete remission after neoadjuvant chemotherapy in breast cancer patients."
2.	Carcinoma (Carcinomatosis) 11/01/2015 - "In vitro studies revealed that therapeutic efficacy of the combinatorial approach was enhanced when compared to PDT alone and this enhancement was more pronounced in ovarian carcinoma cells, which are characterized by higher basal levels of DJ-1 protein. " 07/01/2012 - "By immunohistochemistry DJ-1 protein expression was lower than adjacent non-cancerous epithelium in 6 (14.6%) of the 41 DCISs and 146 (53%) of the 273 IDCs, even although all 314 carcinomas retained expression of DJ-1 mRNA, which was higher than that in adjacent non-cancerous epithelium in 220 cases (70%). " 01/01/2004 - "Up-regulated expression of mammary tumor 8 kDa protein (MAT-8), complement component C1S (C1S), ferritin heavy chain (FTH1), peptidyl-prolyl cis-trans isomerase A (PPIA), RNA-binding protein regulatory subunit DJ-1 protein (DJ-1) and vacuolar ATP synthase subunit F (ATP6V1F) was determined in prostate carcinoma and confirmed by using quantitative real-time RT-PCR analyses. "
3.	Parkinson Disease (Parkinson's Disease) 06/01/2021 - "DJ-1 Protein and Its Role in the Development of Parkinson's Disease: Studies on Experimental Models." 02/27/2004 - "Our studies revealed that the Parkinson's disease-linked L166P mutation impaired the intrinsic folding propensity of DJ-1 protein, resulting in a spontaneously unfolded structure that was incapable of forming a homodimer with itself or a heterodimer with wild-type DJ-1. " 01/01/2023 - "Decreased DJ-1 protein impairs antioxidative activity of neurons and plays an important role in the occurrence of Parkinson's disease (PD). " 01/01/2023 - "Inhibition by pesticides of the DJ-1/Park7 protein related to Parkinson disease." 11/01/2022 - "The PARK7 gene, which encodes DJ-1 protein, is the causative gene of autosomal recessive early-onset Parkinson's disease. "
4.	Neoplasms (Cancer) 05/21/2022 - "The overexpression of DJ-1 protein and its secretion into the bloodstream has been reported in various neoplasms. " 01/01/2018 - "Increased protein deglycase DJ-1 in cancer cells is known to promote tumor growth; however, its role in CRC progression is not well defined. " 07/01/2012 - "Patients with IDC whose cancer cells showed low expression of DJ-1 protein had significantly shorter disease-free survival (P = 0.0152) and overall survival (P = 0.0196) than those whose cancer cells retained DJ-1 expression. " 06/01/2012 - "In contrast, the average DJ-1 concentration in samples from 63 women with benign lesions was 2.7 ng/mL, demonstrating that higher DJ-1 protein levels were detected in nipple fluid in the presence of cancer cells than in the presence of benign lesions (P < 0.0001). " 06/01/2010 - "Tumor recurrence rate (53.3%) in the patients with higher expression of DJ-1 protein was higher than the rate (26.8%) in the patients with lower expression of DJ-1 protein (χ(2) = 5.164, P < 0.05). "
5.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2020 - "Using a patient-based in vitro model of PARK7-linked PD, we identified a U1-dependent splicing defect causing a drastic reduction in DJ-1 protein and, consequently, mitochondrial dysfunction. " 01/01/2017 - "In the present study, we explored the protective effect of a possible DJ-1 agonist, sodium phenylbutyrate (SPB), against I/R injury by protecting mitochondrial dysfunction via the upregulation of DJ-1 protein. " 01/01/2022 - "The novel mutation caused DJ-1 protein deficiency, led to mitochondrial dysfunction, inhibited cell proliferation, and anti-oxidant defense." 01/01/2021 - "Subsequent alterations of PARK7 protein function lead to mitochondrial dysfunction, a major element in PD pathology. " 01/01/2020 - "After prioritization of candidate drugs, we identified and validated a combinatorial treatment with the small-molecule compounds rectifier of aberrant splicing (RECTAS) and phenylbutyric acid, which restored DJ-1 protein and mitochondrial dysfunction in patient-derived fibroblasts as well as dopaminergic neuronal cell loss in mutant midbrain organoids. "

Related Drugs and Biologics

1.	1-phenyl-3,3-dimethyltriazene (PDT)
2.	Proteins (Proteins, Gene)
3.	Biomarkers (Surrogate Marker)
4.	Antioxidants
5.	Prohibitins
6.	PTEN Phosphohydrolase (PTEN Phosphatase)
7.	Protein Isoforms (Isoforms)
8.	Glucose (Dextrose)
9.	Monoclonal Antibodies
10.	Kelch-Like ECH-Associated Protein 1

Related Therapies and Procedures

1.	Neoadjuvant Therapy
2.	Therapeutics
3.	Photochemotherapy (Photodynamic Therapy)
4.	Intraperitoneal Injections