CDX2 Transcription Factor

An antennapedia-like homeodomain transcription factor that regulates the expression of multiple genes in the INTESTINAL MUCOSA. It plays a critical role in many processes from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

Also Known As:

CDX2 Protein; Caudal Type Homeo Box 2 Protein; Caudal Type Homeo Box Transcription Factor 2; Caudal Type Homeobox Transcription Factor 2; Cdx-2 Protein; Cdx-2-3 Protein; Cdx-3 Protein; Homeobox Protein CDX-2; Homeobox Protein CDX2; Transcription Factor CDX2; CDX-2, Homeobox Protein; CDX2, Homeobox Protein; CDX2, Transcription Factor; Cdx 2 3 Protein; Cdx 2 Protein; Cdx 3 Protein; Homeobox Protein CDX 2

Networked: 105 relevant articles (1 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Duluc, I: 4 articles (09/2013 - 01/2008)
2.	Freund, J-N: 4 articles (09/2013 - 01/2008)
3.	Coskun, Mehmet: 3 articles (01/2018 - 04/2010)
4.	Martin, E: 3 articles (09/2013 - 01/2008)
5.	Hisamori, Shigeo: 2 articles (11/2019 - 01/2016)
6.	Hirata, Eiji: 2 articles (11/2019 - 01/2016)
7.	Koh, Iemasa: 2 articles (11/2019 - 01/2016)
8.	Kudo, Yoshiki: 2 articles (11/2019 - 01/2016)
9.	Nosaka, Suguru: 2 articles (11/2019 - 01/2016)
10.	Troelsen, Jesper Thorvald: 2 articles (01/2018 - 06/2013)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 07/01/2015 - "Overexpression of caudal type homeobox transcription factor 2 inhibits the growth of the MGC-803 human gastric cancer cell line in vivo." 03/01/2013 - "Gastric cancer (GC) patients who were positive for caudal type homeobox transcription factor 2 (CDX2) expression showed a higher survival rate compared with those who were CDX2 negative, which suggests that CDX2 performs a tumor suppressor role. " 10/01/2015 - "Recent studies showed that nuclear transcription factor caudal type homeobox transcription factor 2 (CDX2) is a prognostic factor, which acts as a marker of good outcome in gastric cancer (GC) patients. " 12/30/2008 - "[Expression of guanylyl cyclase-c and caudal type homeobox transcription factor 2 in human gastric cancer and precursor lesions]." 02/01/2006 - "The expression of CDX2 protein and mRNA was significantly higher in intestinal-type gastric cancer than in diffuse-type gastric cancer (54.55% vs. 27.78%, 45.45% vs. 22.22%, P<0.05). "
2.	Adenocarcinoma 03/01/2006 - "Recent studies showed that CDX-2 protein expression by immunohistochemistry (IHC) has a high predictive value for confirming the diagnosis of colorectal adenocarcinoma (ACA). " 11/01/2007 - "To characterize the previously unpublished immunohistochemical expression of the relatively new tissue-specific transcription factor Cdx2 in metastatic adenocarcinomas to the brain. " 11/01/2005 - "CDX2 protein expression was assessed by immunohistochemistry in specimens of normal squamous esophagus (n = 13), IM (n = 10), dysplasia (n = 8,) and adenocarcinoma (n = 5). " 07/01/2005 - "Immunostaining with the nuclear transcription factor Cdx2, expressed in normal intestinal epithelia and colorectal adenocarcinomas, could be of potential diagnostic use. " 05/01/2004 - "Expression of CDX2 protein is a new, highly specific and sensitive marker of the intestinal origin of adenocarcinomas. "
3.	Colorectal Neoplasms (Colorectal Cancer) 11/01/2016 - "In the present study, the methylation status of caudal type homeobox transcription factor 2 (CDX2) gene in lesion tissue of colorectal cancer (CRC) was investigated. " 05/15/2014 - "The aim of this study is to determine the specificity of Cdx2 protein expression and CpG promoter hypermethylation for BRAF(V600E) and high-level CIMP in colorectal cancer. " 08/01/2023 - "Colorectal cancer (CRC) with reduced expression of the homeobox transcription factor CDX2, a master gene essential for the development and maintenance of the intestinal tract, is known as a poor prognosis subtype of CRC. " 02/01/2023 - "SATB2 expression in specimens of biopsy, resected primary colorectal carcinomas, and resected metastatic foci were examined by immunohistochemistry and compared to caudal-type homeobox transcription factor 2 (CDX2). " 01/01/2021 - "The transcription factor Cdx2, and to a lesser extent Cdx1, plays essential roles in intestinal homeostasis, and acts as a context-dependent tumour suppressor in colorectal cancer. "
4.	Carcinoma (Carcinomatosis) 05/01/2008 - "A clinicopathological study on the expression of cadherin-17 and caudal-related homeobox transcription factor (CDX2) in human gastric carcinoma." 07/07/2012 - "To investigate the expression and significance of caudal-related homeobox transcription factor (Cdx2) in gastric carcinoma (GC) and precancerous lesions. " 07/15/2009 - "The homeodomain transcription factor CDX2 is a relatively specific immunohistochemical marker for gastrointestinal carcinoma. " 03/01/2009 - "Even in cases of completely gastric and predominantly gastric phenotypes, CDX2 protein was expressed in most cases (90.9% of pT1 and 100% of pT2-3), indicating a possibility that intestinalization of carcinoma cells occurs independently of the background mucosa. " 05/01/2008 - "The association of CDH17, CDX2 protein expression with the clinicopathological characteristics, and with the prognosis of gastric carcinoma were subsequently assessed. "
5.	Colonic Neoplasms (Colon Cancer) 01/01/2021 - "The present study aimed to validate the prognostic value of CDX2 protein expression in colon cancer tissue by routine immunohistochemistry and to evaluate its performance in a head-to-head comparison with tandem mass spectrometry-based proteomics. " 01/01/2021 - "Low levels of CDX2 protein expression in stage II and III colon cancer as determined by immunohistochemistry was associated with poor DSS (hazard ratio [HR] = 1.97 (95% confidence interval [CI]: 1.26-3.06); p = 0.002). " 01/21/2016 - "In the validation data set, which included 314 patients, the rate of 5-year disease-free survival was lower among the 38 patients (12.1%) with CDX2 protein-negative colon cancers than among the 276 (87.9%) with CDX2 protein-positive colon cancers (hazard ratio, 2.42; 95% CI, 1.36 to 4.29; P=0.003). " 10/01/2002 - "In colon cancer cells, PTEN stimulates Cdx-2 protein expression and the transcriptional activity of the Cdx-2 promoter. " 09/25/2009 - "Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2."

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10.	Paraffin

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)