beta-Arrestins

Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They bind and recruit many different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES; and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors to determine the specificity of the cellular response to signaling.

Also Known As:

Networked: 73 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lefkowitz, Robert J: 7 articles (05/2009 - 01/2004)
2.	Pei, Gang: 3 articles (08/2008 - 02/2006)
3.	Ge, Lan: 3 articles (07/2007 - 09/2003)
4.	Shenoy, Sudha K: 3 articles (07/2005 - 10/2004)
5.	Bagnato, Anna: 2 articles (08/2010 - 02/2009)
6.	Cianfrocca, Roberta: 2 articles (08/2010 - 02/2009)
7.	Di Castro, Valeriana: 2 articles (08/2010 - 02/2009)
8.	Natali, Pier Giorgio: 2 articles (08/2010 - 02/2009)
9.	Rosanò, Laura: 2 articles (08/2010 - 02/2009)
10.	Spinella, Francesca: 2 articles (08/2010 - 02/2009)

Related Diseases

1.	Dyslipidemias (Dyslipidemia) 05/01/2009 - "Furthermore, G protein-biased ligands that activate GPR109A in a beta-arrestin-independent fashion may represent an improved therapeutic option for the treatment of dyslipidemia."
2.	Pain (Aches) 01/01/2022 - "However, neither G protein-biased agonists nor beta-arrestin-biased agonists are very effective in assays of pain-depressed behavior, which suggests that novel biased agonists may still not be effective analgesics. "
3.	Neoplasms (Cancer) 07/01/2005 - "To our knowledge this is the first study demonstrating a defined molecular role of beta-arrestin with direct relevance to cell growth and cancer." 12/01/2009 - "PAR2 also uniquely triggers tumor cell migration by G protein-independent pathways through beta-arrestin scaffolding. " 07/13/2007 - "Protease-activated receptor-2 (PAR-2), a Galpha(q/11)-coupled receptor, which has been proposed as a therapeutic target for inflammation and cancer, requires the scaffolding function of beta-arrestins for chemotaxis. " 05/01/2009 - "Affinity chromatography results for gefitinib are discussed in detail and while two out of the three kinases with the highest affinity to gefitinib in biochemical assays are detected by affinity chromatography, also the possible involvement of NSF as a target for modulating cancer progressions via beta-arrestin can be proposed by this method." 02/01/2008 - "beta-arrestins (beta-Arrs) are known to be associated with tumor signaling pathways such as transforming growth factor-beta1 (TGF-beta1), P53/Murine double minute (MDM2) and NF-kappaB. "
4.	Ovarian Neoplasms (Ovarian Cancer) 02/24/2009 - "ZD4054 treatment significantly inhibits metastases, suggesting that specific ET(A)R antagonists, by disabling multiple signaling activated by ET(A)R/beta-arrestin, may represent new therapeutic opportunities for ovarian cancer." 02/24/2009 - "Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis." 08/01/2010 - "Because several G protein-coupled receptors have been shown to activate signalling pathways in a beta-arrestin-dependent manner, in this study we explored whether beta-arrestin-1 is involved in a distinct signalling mechanism linking the ETAR to phosphoinositide 3-kinase (PI3K)/integrin-linked kinase (ILK)/Akt in HEY ovarian cancer cells. " 02/24/2009 - "Here, we demonstrate that, in ovarian cancer cells, beta-arrestin is recruited to ET(A)R to form two trimeric complexes: one through the interaction with Src leading to epithelial growth factor receptor (EGFR) transactivation and beta-catenin Tyr phosphorylation, and the second through the physical association with axin, contributing to release and inactivation of glycogen synthase kinase (GSK)-3beta and beta-catenin stabilization. "
5.	Lung Injury 01/01/2015 - "This study suggests that in the CLP-induced lung injury model, PHC could reduce pulmonary microvascular permeability by upregulating expressions of beta arrestins." 01/01/2015 - "This study is to investigate the effects of PHC on pulmonary microvascular permeability and on expressions of beta arrestins in lung injury induced by the cecal ligation and puncture (CLP) procedure. "

Related Drugs and Biologics

1.	GTP-Binding Proteins (G-Protein)
2.	Ligands
3.	Analgesics (Analgesic Drugs)
4.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
5.	Messenger RNA (mRNA)
6.	beta Adrenergic Receptors
7.	Phosphatidylinositols (Phosphatidylinositol)
8.	integrin-linked kinase
9.	Proteins (Proteins, Gene)
10.	Arrestin

Related Therapies and Procedures

1.	Punctures
2.	Ligation
3.	Therapeutics