Alpha-Ketoglutarate-Dependent Dioxygenase FTO

A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.

Also Known As:

Networked: 139 relevant articles (1 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Jianjun: 5 articles (01/2022 - 01/2018)
2.	Deng, Xiaolan: 4 articles (01/2022 - 01/2018)
3.	Su, Rui: 4 articles (01/2022 - 01/2018)
4.	Ai, Yilong: 2 articles (09/2022 - 01/2021)
5.	Cheng, Xiufeng: 2 articles (09/2022 - 01/2021)
6.	Gao, Yijun: 2 articles (09/2022 - 01/2021)
7.	Gu, Yangcong: 2 articles (09/2022 - 01/2021)
8.	Li, Xia: 2 articles (09/2022 - 01/2021)
9.	Zhang, Jianming: 2 articles (09/2022 - 01/2021)
10.	Yang, Li: 2 articles (05/2022 - 10/2017)

Related Diseases

1.	Infections 12/22/2022 - "The results of the present study show that fat-mass- and obesity-associated protein (FTO), also known as a m6A demethylase, improved the innate immunity and prevented Siniperca chuatsi rhabdo virus and Vibrio anguillarum infection in miiuy croaker. " 01/01/2021 - "parvum infection is associated with downregulation of alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 and the fat mass and obesity-associated protein with the involvement of NF-кB signaling. "
2.	Neoplasms (Cancer) 01/01/2023 - "FTO gene alpha-ketoglutarate dependent dioxygenase linkage disequilibrium block Single-Nucleotide Polymorphism rs9939609 and rs9940128 threating inference was significant in the cancer and diabetes subjects correspondingly. " 01/01/2022 - "Fat mass and obesity-associated protein (FTO) is a demethylase and plays a vital role in various cancers. " 01/01/2022 - "The multifaceted functions of the Fat mass and Obesity-associated protein (FTO) in normal and cancer cells." 11/01/2021 - "The aberrant expression of fat mass and obesity-associated protein (FTO) has been confirmed to be associated with a variety of cancers and participates in the regulation of multiple biological behaviours. " 01/01/2018 - "In this study, by data mining The Cancer Genome Atlas (TCGA) database, we first identified fat mass- and obesity-associated protein (FTO) as a prognostic factor for lung squamous cell carcinoma (LUSC). "
3.	Obesity 01/01/2020 - "Previous studies could prove a fundamental role of FTO (fat mass and obesity-associated protein) within obesity; however, its functional role within different cell types is less understood. " 02/22/2023 - "Children carrying the minor allele 'A' at the fat mass and obesity-associated protein (FTO) gene have higher obesity prevalence. " 01/01/2022 - "Genome-wide association studies have identified the alpha-ketoglutarate dependent dioxygenase gene (FTO) as the first susceptibility gene of obesity. " 01/01/2020 - "Fat mass and obesity-associated protein (FTO) variants are among genetic variants frequently associated with obesity. " 01/01/2019 - "The Iroquois homeobox 3 (Irx3) gene has been identified as a functional long-range target of obesity-associated variants within the fat mass and obesity-associated protein (FTO) gene. "
4.	Wilms Tumor (Wilm's Tumor) 01/01/2016 - "The dynamic and reversible modification is installed by methyltransferase complex charactered three subunits: METTL3 (Methyltransferase-like protein 3), METTL14 (Methyltransferase-like protein 14) and WTAP (Wilms tumor 1-associating protein), and erased by two independent demethylases, FTO (Fat mass and obesity associated protein) and ALKBH5 (AlkB homolog 5), in an α-ketoglutarate (α-KG)- and Fe(II)-dependent manner. " 04/01/2022 - "The mRNA and protein expression levels of m6A modification-related molecules methyltransferase-like 3 (METTL3), METTL14, METTL16, Wilm's tumor 1-associated protein (WTAP), alkylation repair homolog protein 5 (ALKBH5), fat-mass and obesity-associated protein (FTO), YTH domain-containing 1 (YTHDC1), YTHDC2 were detected through real-time quantitative PCR and Western blot, respectively. " 01/01/2022 - "Quantitative reverse transcription PCR (RT-qPCR), immunofluorescence, and Western blotting revealed that the RNA demethylase fat mass and obesity-associated protein (FTO) was downregulated, whereas the RNA methylases methyltransferase-like 14 (METTL14) and wilms' tumor 1-associating protein (WTAP) were upregulated. " 01/01/2022 - "This study has focused on determining the association of m6A methyltransferase [methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), and Wilms tumor 1-associating protein (WTAP)], demethylase [fat mass and obesity-associated protein (FTO) and alkylation repair homolog protein 5 (ALKBH5)], RNA-binding proteins [YT521-B homology domains 2 (YTHDF2)], and ankylosing spondylitis (AS). " 01/01/2022 - "Compared with healthy control, m6A RNA methyltransferase 3 (METTL3) and METTL14 increased, while Wilms tumor 1-associated protein (WTAP) and RNA-binding motif protein 15 (RBM15) decreased significantly in NAFLD, and the m6A demethylases fat mass and obesity-associated protein (FTO) elevated. "
5.	Body Weight (Weight, Body) 01/10/2019 - "Fat mass and obesity-associated protein gene variants have shown diverse influence on body weight and metabolism across different populations. " 01/01/2019 - "Fat mass and obesity-associated protein (FTO) has been well known for a pivotal role in regulation of fat mass, adipogenesis and body weight. " 01/01/2013 - "The recently-identified fat mass and obesity-associated (FTO) protein is associated with various physiological functions including energy and body weight regulation. " 10/01/2017 - "Fat mass and obesity-associated (FTO) protein is a recently identified RNA demethylase, and its overexpression in mice leads to increased body weight as well as fat mass. " 01/01/2022 - "In the current study, we identified the obesity risk or protective association and BMI raising effect of the minor allele of adiponectin, C1Q and collagen domain containing (ADIPOQ), cholesteryl ester transfer protein (CEPT), FTO alpha-ketoglutarate dependent dioxygenase (FTO), leptin (LEP), and leptin receptor (LEPR) genes in a large cohort stratified into four BMI-based body weight categories i.e., normal weight, lean, over-weight, and obese. "

Related Drugs and Biologics

1.	6-methyladenine
2.	RNA (Ribonucleic Acid)
3.	N-methyladenosine
4.	Methyltransferases
5.	Proteins (Proteins, Gene)
6.	RNA-Binding Proteins (RNA-Binding Protein)
7.	Leptin
8.	Cisplatin (Platino)
9.	Leptin Receptors
10.	Cholesterol Ester Transfer Proteins

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy