Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3

A dioxygenase and alkylation repair homolog that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. It has a strong preference for SINGLE-STRANDED DNA and may also act on RNA.

Also Known As:

AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; Alkylated DNA Repair Protein AlkB Homolog 3; Prostate Cancer Antigen 1; AlkB Homolog 3, Alpha Ketoglutarate Dependent Dioxygenase; Alpha Ketoglutarate Dependent Dioxygenase AlkB Homolog 3

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Dioxygenases: 495
        AlkB Enzymes: 4
        Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3: 2
        human ALKBH3 protein
        mouse Alkbh3 protein
  - DNA Repair Enzymes: 492
    - AlkB Enzymes: 4
      - Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3: 2
        human ALKBH3 protein
        mouse Alkbh3 protein

Experts

1.	Tsujikawa, Kazutake: 2 articles (01/2018 - 08/2015)
2.	Hase, Hiroaki: 1 article (01/2018)
3.	Horiike, Kota: 1 article (01/2018)
4.	Kitae, Kaori: 1 article (01/2018)
5.	Mabuchi, Miyuki: 1 article (01/2018)
6.	Shimizu, Tadashi: 1 article (01/2018)
7.	Tanaka, Akito: 1 article (01/2018)
8.	Ueda, Masahiro: 1 article (01/2018)
9.	Ueda, Yuko: 1 article (01/2018)
10.	Anai, Satoshi: 1 article (08/2015)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2018 - "Novel potent prostate cancer antigen-1 (PCA-1)/alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3) inhibitors both in vivo and in vivo were designed and evaluated by a stability assay in an S9 mixture, a mixture of rat liver homogenate and co-factors, and oral absorbability assay in rat, as well as enzyme and cell assays, and resulted in the synthesis of a novel potent PCA-1/ALKBH3 inhibitor in vivo. "
2.	Renal Cell Carcinoma (Grawitz Tumor) 08/01/2015 - "Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma."

Related Drugs and Biologics

1.	Enzymes