AlkB Enzymes

A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE).

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Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Keng-Yu: 1 article (11/2020)
2.	Cheng, Yuan-Yuan: 1 article (11/2020)
3.	Liu, Jia-Ming: 1 article (11/2020)
4.	Liu, Zhong-Qiu: 1 article (11/2020)
5.	Xian, Cui-Ling: 1 article (11/2020)
6.	Xiao, Ming-Zhu: 1 article (11/2020)
7.	Klungland, Arne: 1 article (12/2015)
8.	Larsen, Elisabeth: 1 article (12/2015)
9.	Ougland, Rune: 1 article (12/2015)
10.	Rognes, Torbjørn: 1 article (12/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "We provide some new directions for the AlkB homologs in cancer research. " 01/01/2023 - "To date, nine AlkB homologs as demethylases have been identified in numerous cancers' biological processes. " 01/01/2023 - "The role of demethylase AlkB homologs in cancer." 10/01/2005 - "In mammals, the corresponding AlkB homologs may defend against aging, cancer and oxidative stress." 01/01/2023 - "In this review, we summarize the latest advances in the research of the structures, enzymatic activities, and substrates of the AlkB homologs and the role of these nine homologs as demethylases in cancer genesis, progression, metastasis, and invasion. "
2.	Inflammation (Inflammations) 11/01/2020 - "Importantly, we discuss the roles of ALKB homologs in the regulation of oxidative stress, inflammation, autophagy, and DNA damage in CVDs, as well as the practical applications of ALKB homologs inhibitors or agonists in treating CVDs. " 12/01/2015 - "The phenotypes of organisms lacking or overexpressing individual AlkB homologs include obesity, severe sensitivity to inflammation, infertility, growth retardation, and multiple malformations. "
3.	Morbid Obesity 12/01/2015 - "The phenotypes of organisms lacking or overexpressing individual AlkB homologs include obesity, severe sensitivity to inflammation, infertility, growth retardation, and multiple malformations. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2023 - "In this review, we summarize the latest advances in the research of the structures, enzymatic activities, and substrates of the AlkB homologs and the role of these nine homologs as demethylases in cancer genesis, progression, metastasis, and invasion. "
5.	Infertility (Sterility) 12/01/2015 - "The phenotypes of organisms lacking or overexpressing individual AlkB homologs include obesity, severe sensitivity to inflammation, infertility, growth retardation, and multiple malformations. "