APOBEC-3G Deaminase

An APOBEC deaminase that functions as an inhibitor of RETROVIRIDAE replication and inhibits the mobility of RETROTRANSPOSONS via deaminase-dependent and independent mechanisms. It is selective for SINGLE-STRANDED DNA and does not deaminate double-stranded DNA or single or DOUBLE-STRANDED RNA. It exhibits potent antiviral activity against VIF PROTEIN deficient HIV-1 through the creation of hypermutations in the VIRAL DNA. It also has anti-viral activity against SIMIAN IMMUNODEFICIENCY VIRUSES and HEPATITIS B VIRUS.

Also Known As:

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Li, Zelin: 1 article (03/2011)
2.	Qiao, Xinhua: 1 article (03/2011)
3.	Zeng, Yi: 1 article (03/2011)
4.	Zhang, Wenjun: 1 article (03/2011)
5.	Kryworuchko, Marko: 1 article (07/2008)
6.	Kumar, Ashok: 1 article (07/2008)
7.	Sirskyj, Danylo: 1 article (07/2008)
8.	Thèze, Jacques: 1 article (07/2008)
9.	Kremer, Melanie: 1 article (10/2006)
10.	Martinez-Fernandez, Yolanda: 1 article (10/2006)

Related Diseases

1.	Infections 10/19/2006 - "However, Western blot analysis showed that the levels of APOBEC3G protein were not affected by vaccinia virus infection. " 10/19/2006 - "The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. " 03/01/2011 - "The mammalian APOBEC3G protein (apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 protein G, APOBEC3G) is an important component of the cellular innate immune response to retroviral infection. "
2.	HIV Infections (HIV Infection) 07/01/2008 - "Interestingly, IL-2 and IL-15 are also able to render CD4+ T cells permissive to HIV infection through their influence on the activity of the APOBEC3G deaminase enzyme. "

Related Drugs and Biologics

1.	Interleukin-15 (Interleukin 15)
2.	Proteins (Proteins, Gene)
3.	Peptides (Polypeptides)
4.	Interleukin-2 (IL2)
5.	Enzymes
6.	APOBEC-1 Deaminase