12E7 Antigen

A cell adhesion molecule that, in humans, is encoded by a gene on the PSEUDOAUTOSOMAL REGION of SEX CHROMOSOMES. It functions in CELL ADHESION of T-LYMPHOCYTES and ROSETTE FORMATION by ERYTHROCYTES. It is also involved in the migration of LEUKOCYTES through the ENDOTHELIUM BASEMENT MEMBRANE. The 12E7 antigen co-localizes with, but functions independently of PECAM-1.

Also Known As:

12E7 Protein; Antigens, CD99; CD99 Antigen; CD99 Molecule; E2 Antigen; MIC2 Protein; T-Cell Surface Glycoprotein E2; Antigen, 12E7; Antigen, CD99; Antigen, E2; CD99 Antigens; T Cell Surface Glycoprotein E2

Networked: 43 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cheng, Jun: 2 articles (10/2002 - 04/2002)
2.	Li, Li: 2 articles (10/2002 - 04/2002)
3.	Wang, Gang: 2 articles (10/2002 - 04/2002)
4.	Chen, Chen: 1 article (03/2021)
5.	Deng, Yao-Tiao: 1 article (03/2021)
6.	Jiang, Yu: 1 article (03/2021)
7.	Li, Zhi-Ke: 1 article (03/2021)
8.	Liu, Jie: 1 article (03/2021)
9.	Yang, Ke-Yi: 1 article (03/2021)
10.	Li, Huixin: 1 article (10/2019)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2007 - "The generated MAbs can be used for future study of the function and mechanism of the CD99 molecule, including its role in the immune system, and may have application in tumor diagnosis and treatment." 09/01/2013 - "Excisional biopsy revealed solid tumor with large cavities filled with straw-colored fluid and tumor cells that stained positive for CD34 and CD99 antigens, consistent with SFT. " 01/01/2013 - "Finally, it was tested for staining CD99 antigen on a large panel of tumor and normal cells and tissues by cytofluorimetric and immunohistochemical assays. " 07/01/2004 - "Immunohistochemically, the tumor cells showed intense cell membranous immunoreactivity for MIC2 protein (CD99). " 01/01/2000 - "Both the expression of Mic2 protein and t(11;22)(q24;q12) translocation were proved in the tumor cells. "
2.	Infections 02/01/2009 - "To construct a recombinant lentivirus harboring RNA interference sequence targeting mouse CD99 antigen-like 2 (mCD99L2) gene and observe its infection efficiency of 293FT cells. " 01/01/1980 - "These two separate studies suggest that not only e2 antigen but also e1 antigen are associated with the infection of HBV, but they are distinct from each other; the e2 antigen may have the properties of a signal of the viral activity in the patient as suggested by many others, but e1 antigen does not seem to bear such diagnostic values." 09/01/2005 - "Infection of HCV was demonstrated by positivity for the E2 antigen within THP-1 cells and by indirect immunofluorescence; moreover, HCV-RNA was detected in supernatants of THP-1 cells from day 7 post-inoculation. " 11/01/1998 - "Evaluation of previous HGV infection was carried out by detection of antibodies to E2 antigen. " 01/01/1980 - "In four cases out of five, in which e2 antigen was detected during the course of infection, the initial detection of e2 antigen occurred at or just before the elevation of liver enzyme levels. "
3.	Virus Diseases (Viral Diseases) 02/01/2008 - "The capacity of goat milk-derived E2 antigen to protect pigs from both classical swine fever clinical signs and viral infection was assessed in a vaccination and challenge trial. " 05/01/2023 - "Development and application of an indirect ELISA for the serological detection of bovine viral diarrhea virus infection based on the protein E2 antigen."
4.	Classical Swine Fever (Swine Fever) 02/01/2008 - "The capacity of goat milk-derived E2 antigen to protect pigs from both classical swine fever clinical signs and viral infection was assessed in a vaccination and challenge trial. "
5.	Ewing Sarcoma (Sarcoma, Ewing) 07/01/2013 - "siRNA associated with immunonanoparticles directed against cd99 antigen improves gene expression inhibition in vivo in Ewing's sarcoma." 01/01/1992 - "In the present investigation we have tested the sensitivities of two embedding-labile epitopes (HBA-71 and HBA-45) of the Ewing's sarcoma-associated MIC2-encoded E2 antigen to the effects of the different treatment steps, which are necessary for the preparation of ultrathin sections. " 01/15/2005 - "Immunohistochemical staining was positive for vimentin, synapsin, CD99 (MIC2 protein), and FLI-1, prompting an initial diagnosis of Ewing sarcoma/primitive neuroectodermal tumor. " 03/01/2021 - "Preoperative biopsy pathology results suggested an Ewing sarcoma that was positive for CD99 antigen, vimentin, friend leukaemia integration 1 transcription factor, apoptosis regulator Bcl-2, and synaptophysin; and negative for CD34 antigen, S-100 protein (S-100), smooth muscle antigen, cytokeratin, and Wilms tumour 1 associated protein. "

Related Drugs and Biologics

1.	Antigens
2.	Proteins (Proteins, Gene)
3.	Vimentin
4.	Keratins (Keratin)
5.	Mucin-1 (CA 15-3 Antigen)
6.	Phosphopyruvate Hydratase (Enolase)
7.	Single-Chain Antibodies
8.	Synaptophysin
9.	RNA (Ribonucleic Acid)
10.	Enzymes