Twist-Related Protein 2

A twist family transcription factor that is expressed in MESODERM as well as the DERMIS during mammalian EMBRYOGENESIS. It is structurally and functionally similar to TWIST-RELATED PROTEIN 1; it also regulates OSTEOGENESIS and the expression of CYTOKINES in response to INFLAMMATION.

Also Known As:

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wang, Xin: 2 articles (12/2021 - 10/2019)
2.	Zhang, Wei: 2 articles (01/2021 - 10/2019)
3.	Chen, Yanping: 1 article (01/2022)
4.	Ding, Niu: 1 article (01/2022)
5.	Duan, Xiaojun: 1 article (01/2022)
6.	Liu, Dian: 1 article (01/2022)
7.	Ma, Song: 1 article (01/2022)
8.	Zhang, Jin: 1 article (01/2022)
9.	Long, Xiongwu: 1 article (12/2021)
10.	Pu, Qianqian: 1 article (12/2021)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2019 - "In accordance with these findings, PCa tumor tissues showed markedly decreased TWIST2 protein expression compared to that in both normal and prostatic intraepithelial neoplasia tissues by immunohistochemical staining. " 02/01/2015 - "By comparing the expression of EMT-related proteins in 31 cases of cervical tumors and tumor adjacent tissues and exploring the relationship between HPV16 oncogenes and EMT in vitro, we found that Twist2 protein levels were significantly higher in CIN and cervical cancer than in normal cervical squamous epithelial samples (p<0.01 and p<0.001, respectively). "
2.	Non-alcoholic Fatty Liver Disease 04/20/2021 - "To investigate the roles of the transcription factors twist family bHLH transcription factor 1 (TWIST1), twist family bHLH transcription factor 2 (TWIST2), and peroxisome proliferator activated receptor gamma (PPARγ) in the progression of nonalcoholic steatohepatitis. "
3.	Carcinogenesis 01/01/2021 - "Twist related protein 2 (TWIST2) plays an important role in bone development, tumorigenesis, tumour progression and epithelial mesenchymal transition (EMT). "
4.	Lung Injury 01/01/2022 - "Apart from that, TWIST2 protein could reduce the inflammatory reaction in mice model with infantile pneumonia, resulting in an inhibition in lung injury. "
5.	Prostatic Intraepithelial Neoplasia 10/01/2019 - "In accordance with these findings, PCa tumor tissues showed markedly decreased TWIST2 protein expression compared to that in both normal and prostatic intraepithelial neoplasia tissues by immunohistochemical staining. "

Related Drugs and Biologics

1.	Sirtuin 1
2.	Adipokines
3.	Basic Helix-Loop-Helix Transcription Factors
4.	PPAR gamma
5.	MicroRNAs (MicroRNA)
6.	Proteins (Proteins, Gene)
7.	Twist Transcription Factors
8.	Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
9.	fibroblast growth factor 21