Twist Transcription Factors

A highly-conserved family of basic helix-loop-helix (bHLH) transcription factors. They function as dimers with other bHLH proteins and bind E-BOX ELEMENTS to control gene expression during EMBRYOGENESIS and the EPITHELIAL-MESENCHYMAL TRANSITION.

Also Known As:

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gao, Peng: 1 article (04/2021)
2.	Ge, Xiaoxiao: 1 article (04/2021)
3.	Hao, Mingju: 1 article (04/2021)
4.	Li, Yongqing: 1 article (04/2021)
5.	Lu, Sumei: 1 article (04/2021)
6.	Ma, Wanshan: 1 article (04/2021)
7.	Sun, Tao: 1 article (04/2021)
8.	Wang, Peijun: 1 article (04/2021)
9.	Zhang, Bingyang: 1 article (04/2021)
10.	Zhang, Yanmei: 1 article (04/2021)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2017 - "The transcription factors Twist, Snail, Slug, ZEB1 and ZEB2 regulate epithelial-mesenchymal transition (EMT) and their expression has been associated with a poor prognosis in several cancer entities. " 03/01/2021 - "The transcription factors Twist, Slug and Snail regulate epithelial-mesenchymal transition and thereby participate in tumor invasion and metastasis. " 02/23/2016 - "Inhibition of epithelial-mesenchymal transition (EMT)-inducing transcription factors Twist and Snail prevents tumor metastasis but enhances metastatic growth. "
2.	Neoplasm Metastasis (Metastasis) 03/01/2021 - "The transcription factors Twist, Slug and Snail regulate epithelial-mesenchymal transition and thereby participate in tumor invasion and metastasis. " 02/23/2016 - "Inhibition of epithelial-mesenchymal transition (EMT)-inducing transcription factors Twist and Snail prevents tumor metastasis but enhances metastatic growth. "
3.	Hypoxia (Hypoxemia) 01/01/2018 - "Previous work reported that the transcription factors Twist plays an important role in hypoxia-induced EMT and renal fibrosis. " 11/01/2019 - "As markers of EMT, P-cadherin, N-cadherin, vimentin, nuclear transcription factors Twist and Snail, hypoxia inducible factor 1α (HIF-1α), programmed death ligand 1, and vascular endothelial growth factor D, as well as E-cadherin, were examined using immunohistochemistry, Western blot, and enzyme-linked immunosorbent assay. "
4.	Anaplastic Thyroid Carcinoma 04/01/2019 - "The expression of E-cadherin (E-CAD) and transcription factors TWIST, SLUG and SNAIL in follicular thyroid tumours was examined by immunohistochemistry in tissue samples, including 18 follicular adenomas (FA), 12 minimally invasive follicular thyroid carcinomas (MI-FTC), 16 widely invasive follicular thyroid carcinomas (WI-FTC), 10 poorly differentiated follicular thyroid carcinomas (PDTC) and six anaplastic thyroid carcinomas (ATC). "
5.	Non-alcoholic Fatty Liver Disease 04/20/2021 - "To investigate the roles of the transcription factors twist family bHLH transcription factor 1 (TWIST1), twist family bHLH transcription factor 2 (TWIST2), and peroxisome proliferator activated receptor gamma (PPARγ) in the progression of nonalcoholic steatohepatitis. "

Related Drugs and Biologics

1.	Cadherins (E-Cadherin)
2.	Vimentin
3.	B7-H1 Antigen
4.	Basic Helix-Loop-Helix Transcription Factors
5.	PPAR gamma
6.	Vascular Endothelial Growth Factor D
7.	Ephrin-B1 (Ephrin B1)
8.	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)
9.	Proteins (Proteins, Gene)
10.	Immunosorbents