Nanog Homeobox Protein

A homeodomain protein and transcription regulator that functions in BLASTOCYST INNER CELL MASS and EMBRYONIC STEM CELL proliferation and CELL SELF RENEWAL. It confers pluripotency on embryonic stem cells and prevents their differentiation towards extraembryonic ENDODERM and trophectoderm (TROPHOBLAST) CELL LINEAGES.

Also Known As:

Networked: 35 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Allonca, Eva: 3 articles (07/2020 - 11/2017)
2.	García-Pedrero, Juana M: 3 articles (07/2020 - 11/2017)
3.	Hermida-Prado, Francisco: 2 articles (07/2020 - 11/2017)
4.	Cheng, Chuan-Dong: 2 articles (04/2020 - 05/2013)
5.	Rodrigo, Juan P: 2 articles (09/2019 - 11/2017)
6.	Chen, Dong: 1 article (01/2022)
7.	Cheng, Zhimeng: 1 article (01/2022)
8.	Chung, Raymond T: 1 article (01/2022)
9.	Duan, Xiaoqiong: 1 article (01/2022)
10.	Holmes, Jacinta A: 1 article (01/2022)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 09/01/2012 - "The purpose of this study was to evaluate the expression and regulatory effects of Nanog in colorectal cancer and the correlation between Nanog protein expression and the prognosis of patients with colorectal cancer. " 09/01/2012 - "Nanog protein may be a potential biomarker for postoperative liver metastasis of colorectal cancer."
2.	Neoplasms (Cancer) 10/01/2021 - "Western blots showed that after the transfection of PDPH/pT2SpCas9-Nanog/SB11, Nanog protein in HeLa cells is knocked out, and the proliferation and migration abilities of tumor cells are significantly decreased. " 11/01/2019 - "However, the regulation mechanism of NANOG protein stability in cancer progression is still elusive. " 05/08/2014 - "Notably, in some cancer cell lines, the NANOG protein levels produced by NANOGP8 are comparable to those produced by NANOG1 in pluripotent cells. " 06/01/2012 - "However, no statistical difference of Nanog protein expression between tumor tissues and metastatic lymph nodes was found (P = 0.143). " 06/01/2012 - "We found that Nanog protein immunostaining in tumor tissues was stronger than that in their corresponding non-dysplastic tissues. "
3.	Neoplasm Metastasis (Metastasis) 01/01/2014 - "The expression of NANOG protein was assessed in 60 patients with OSCC by immunohistochemistry, and its correlation with clinicopathological factors and metastasis was evaluated. " 01/01/2018 - "Human homeobox protein (Nanog) is highly expressed in most cancer cells and has gradually emerged as an excellent target in cancer therapy, owing to its regulation of cancer cell proliferation, metastasis and apoptosis. " 09/01/2012 - "Nanog protein may be a potential biomarker for postoperative liver metastasis of colorectal cancer."
4.	Carcinoma (Carcinomatosis) 11/01/2017 - "NANOG protein expression was immunohistochemically evaluated in the ovarian tissue microarrays of 20 patients with benign ovarian serous tumors, 30 patients with borderline ovarian serous tumors, and 109 patients with ovarian serous carcinomas, from which 106 were of high-grade and 3 of low-grade morphology Immunohistochemical reaction was scored according to signal intensity and the percentage of positive cells in tumor samples. " 07/01/2012 - "The electrochemical gold nanoparticle immunosensor is suitable for measuring NANOG protein expression in stem and carcinoma cell tissue lysates at very low levels." 01/01/2018 - "Insulin-deficient islets had reduced expression of factors normally expressed in maturing β-cells, including muscoloaponeurotic fibrosarcoma oncogene homolog A, homeodomain transcription factor 6.1, and glucose transporter 2. Ins1-/-Ins2-/-β-cells expressed progenitor factors associated with stem cells or dedifferentiated β-cells, including v-myc avian myolocytomatosis viral oncogene lung carcinoma derived and homeobox protein NANOG. "
5.	Lymphatic Metastasis 07/04/2020 - "NANOG protein expression was detected in 250 (72%) cases, more frequently in patients with lymph node metastasis (p = 0.003), and was an independent predictor of better survival in multivariate analysis. " 12/01/2016 - "With increasing TNM stage (p < 0.01) and lymphatic metastasis (p < 0.05), the positive expression rate of Nanog protein increased. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Transcription Factor 4
3.	Biomarkers (Surrogate Marker)
4.	Transcription Factors (Transcription Factor)
5.	Facilitative Glucose Transport Proteins (Glucose Transporter)
6.	Catenins
7.	Octamer Transcription Factor-3 (Oct 4 Transcription Factor)
8.	Ubiquitin
9.	Subfamily B ATP Binding Cassette Transporter
10.	Androgen Receptors (Androgen Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)