Uncoupling Protein 3

A mitochondrial uncoupling protein that is expressed in heart and skeletal muscle tissues. It functions to regulate tissue respiration, energy balance, and THERMOGENESIS. Mutations in the UCP3 gene are associated with OBESITY.

Also Known As:

Networked: 136 relevant articles (4 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schrauwen, Patrick: 10 articles (12/2011 - 05/2002)
2.	Hesselink, Matthijs K C: 8 articles (12/2011 - 10/2002)
3.	Harmancey, Romain: 5 articles (01/2021 - 08/2012)
4.	Hoeks, Joris: 4 articles (12/2011 - 01/2006)
5.	Schaart, G: 4 articles (07/2007 - 11/2000)
6.	Schrauwen, P: 4 articles (07/2007 - 11/2000)
7.	Goglia, Fernando: 3 articles (01/2022 - 01/2011)
8.	Lombardi, Assunta: 3 articles (01/2022 - 01/2011)
9.	Ashraf, Sadia: 3 articles (01/2021 - 10/2018)
10.	Clarke, Kieran: 3 articles (10/2018 - 05/2011)

Related Diseases

1.	Insulin Resistance 01/01/2022 - "Ablation of uncoupling protein 3 affects interrelated factors leading to lipolysis and insulin resistance in visceral white adipose tissue." 10/29/2018 - "The mitochondrial uncoupling protein 3 (UCP3) is down-regulated in the heart with insulin resistance. " 01/01/2018 - "UCP3 protein is primarily expressed in the skeletal muscle cells and is involved in energy homeostasis and modulates insulin sensitivity. " 01/01/2013 - "The decreased adiposity in HFD-Leu mice was associated with increased expression of uncoupling protein 3 (UCP-3) in the brown adipose tissue, better insulin sensitivity, increased intestinal gluconeogenesis and preservation of islets of Langerhans histomorphology and function. " 01/01/2011 - "Controversy exists on whether uncoupling protein 3 (UCP3) positively or negatively influences insulin sensitivity in vivo, and the underlying signaling pathways have been scarcely studied. "
2.	Type 2 Diabetes Mellitus (MODY) 10/01/2002 - "In addition our data show that up-regulation of uncoupling protein-3 can be beneficial in the treatment of type 2 diabetes." 11/01/2009 - "Cells from patients with a history of type 2 diabetes were unable to decrease mitochondrial membrane potential in response to HGI, potentially due to lower levels of uncoupling protein-3. " 08/01/2006 - "In patients with type 2 diabetes UCP3 protein in muscle is reduced by 50% compared to healthy controls. " 08/01/2002 - "[Effects of uncoupling protein 3 gene -55 C-->T variant on lipid metabolism, body fat, its distribution and non-insulin-dependent diabetes mellitus in Chinese]." 12/01/2001 - "We found that UCP3 protein levels were twice as low in patients with type 2 diabetes compared with control subjects (117 +/- 16 vs. 58 +/- 12 AU; P = 0.007). "
3.	Hyperphagia (Overeating) 12/01/2002 - "Skeletal muscle mitochondrial efficiency and uncoupling protein 3 in overeating rats with increased thermogenesis." 07/01/2000 - "A reduction of food intake imposed on control rats (pair-feeding), aimed at mimicking leptin-induced hyperphagia, produced a marked decrease in the expression of muscle uncoupling protein-3 (UCP-3), whereas ICV infusion of leptin prevented such a decrease in UCP-3. " 12/01/2002 - "To establish whether changes in skeletal muscle mitochondrial efficiency contribute to increased energy expenditure and decreased metabolic efficiency of overeating rats with increased thermogenesis, we measured basal proton leak, fatty acid-induced uncoupling and uncoupling protein 3 (UCP3) content in subsarcolemmal and intermyofibrillar skeletal muscle mitochondria. "
4.	Infarction (Infarctions) 06/15/2021 - "PPARβ/δ activation improved left ventricular developed pressure recovery, reduced infarct size (IS) and incidence of reperfusion-induced ventricular arrhythmias while it also up-regulated superoxide dismutase 2, catalase and uncoupling protein 3 resulting in attenuation of oxidative stress as evidenced by the reduction in 4-hydroxy-2-nonenal protein adducts and protein carbonyl formation. "
5.	Obesity 07/01/2001 - "Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family Study." 08/01/2000 - "The goal of this study was to determine whether differential induction of skeletal muscle uncoupling protein 3 (UCP3) contributes to the development of diet-induced obesity (DIO) or resistance to the development of obesity (DR) when rats are placed on a moderate fat (31%) high energy (HE) diet. " 01/01/2021 - "The mitochondrial UCP3 (uncoupling protein 3) is downregulated in the heart with obesity. " 05/01/2008 - "Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes." 03/01/2008 - "Uncoupling protein 3 (UCP3) is considered to be associated with obesity, given its function in the regulation of energy and lipid metabolism. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Glucose (Dextrose)
3.	Catalase
4.	Leptin
5.	superoxide dismutase 2
6.	4-hydroxy-2-nonenal (4-hydroxynonenal)
7.	oleoyl-coenzyme A
8.	Messenger RNA (mRNA)
9.	Insulin (Novolin)
10.	Uncoupling Protein 2

Related Therapies and Procedures

1.	Ischemic Postconditioning
2.	Caloric Restriction
3.	Stents