Uncoupling Protein 2

A mitochondrial uncoupling protein that is expressed in many tissues and exhibits the greatest expression in SKELETAL MUSCLE. It regulates mitochondrial ATP production and the generation of REACTIVE OXYGEN SPECIES.

Also Known As:

Networked: 434 relevant articles (12 outcomes, 50 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rubattu, Speranza: 8 articles (05/2022 - 02/2013)
2.	Zhao, Yunfeng: 8 articles (01/2020 - 01/2013)
3.	Stanzione, Rosita: 7 articles (05/2022 - 02/2013)
4.	Ricquier, Daniel: 7 articles (01/2019 - 10/2003)
5.	Bianchi, Franca: 6 articles (05/2022 - 02/2013)
6.	Cotugno, Maria: 6 articles (05/2022 - 02/2013)
7.	Forte, Maurizio: 6 articles (05/2022 - 01/2017)
8.	Marchitti, Simona: 6 articles (05/2022 - 02/2013)
9.	Affourtit, Charles: 6 articles (05/2015 - 01/2008)
10.	Horvath, Tamas L: 6 articles (01/2012 - 11/2002)

Related Diseases

1.	Reperfusion Injury 12/01/2019 - "Uncoupling protein 2 prevents ischaemia reperfusion injury through the regulation ROS/NF-κB signalling in mice." 10/01/2008 - "The effect of target-directed regulation of the uncoupling protein-2 (UCP-2) gene expression on the ischemia-reperfusion injury of hepatocytes under different conditions was investigated. " 10/01/2008 - "Effect of target-directed regulation of uncoupling protein-2 gene expression on ischemia-reperfusion injury of hepatocytes." 12/01/2011 - "Uncoupling protein-2 deficient mice are not protected against warm ischemia/reperfusion injury of the liver." 01/01/2020 - "Deletion of mitochondrial uncoupling protein 2 exacerbates mitophagy and cell apoptosis after cerebral ischemia and reperfusion injury in mice."
2.	Insulin Resistance 04/01/2008 - "[Relationship between the expression of uncoupling protein 2 and insulin resistance in fatty liver rats induced by high-fat food]." 07/01/2004 - "The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes." 12/18/2020 - "The role of uncoupling protein 2 in macrophages and its impact on obesity-induced adipose tissue inflammation and insulin resistance." 05/01/2017 - "In particular, the article describes the role of GE neurons in the control of peripheral glucose utilization and insulin sensitivity, which depend on mitochondrial uncoupling protein 2 of the neurons, as well as that of GI neurons in the control of hepatic glucose production through hypoglycemia-induced counterregulatory mechanisms." 01/01/2016 - "Dyslipidemia, insulin resistance and dietary fat intake in obese and normal weight adolescents: the role of uncoupling protein 2 -866G/A gene polymorphism."
3.	Body Weight (Weight, Body) 10/01/2016 - "Uncoupling protein 2 ( UCP2 ) plays an important role in body weight and energy metabolism and may be related to the control of food consumption. " 04/01/2000 - "Uncoupling protein 2(UCP2) could play an important role in energy metabolism and body weight regulation. " 12/01/1999 - "An untranslated insertion variant in the uncoupling protein 2 gene is not related to body mass index and changes in body weight during a 26-year follow-up in Danish Caucasian men." 10/01/2012 - "Jueming Prescription reduces body weight by increasing the mRNA expressions of beta3-adrenergic receptor and uncoupling protein-2 in adipose tissue of diet-induced obese rats." 01/01/2011 - "No significant differences in adipocyte size and hepatic gene expression were observed after treatment with NT-BVT compared with vehicle treated mice, though NT-BVT also decreased body weight gain, improved glucose tolerance, and increased uncoupling protein-2 (UCP-2) mRNA levels in muscle. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2023 - "Both overexpression of mitochondrial uncoupling protein 2 (UCP2) targeted to SNrGAD2 and SNrGAD2-targeted chemogenetic inhibition targeted to SNrGAD2 rescue mitochondrial dysfunction in TAA-induced HE. " 12/01/2018 - "Mitochondrial dysfunction and ROS production were directly correlated with the expression of uncoupling protein 2 (UCP2). " 08/01/2010 - "To investigate whether mitochondrial dysfunction-associated oxidative stress leads to increased formation and accumulation of AGE, we studied hepatic glycation in uncoupling protein-2 (UCP2-/-) knockout mice. " 01/01/2018 - "Sepsis can trigger mitochondrial dysfunction in myocardial cells, which leads to ROS overproduction, while uncoupling protein 2 (UCP2) can reduce ROS production. " 09/15/2012 - "A further quantitative RT-PCR study showed the down-regulation of ATP synthase and the up-regulation of uncoupling protein 2 (UCP2), which indicated mitochondrial dysfunction. "
5.	Stroke (Strokes) 06/16/2020 - "The downregulation of uncoupling protein-2 (UCP2) is associated with increased brain and kidney injury in stroke-prone spontaneously hypertensive rats (SHRSP) fed with a Japanese style hypersodic diet (JD). " 06/16/2020 - "Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats." 01/01/2017 - "A differential expression of uncoupling protein-2 associates with renal damage in stroke-resistant spontaneously hypertensive rat/stroke-prone spontaneously hypertensive rat-derived stroke congenic lines." 01/01/2012 - "Differential Association of Uncoupling Protein 2 Polymorphisms with Pattern Identification among Korean Stroke Patients: A Diagnostic System in Traditional Korean Medicine." 06/01/2009 - "Neuroprotective role of mitochondrial uncoupling protein 2 in cerebral stroke."

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Proteins (Proteins, Gene)
3.	Messenger RNA (mRNA)
4.	Glucose (Dextrose)
5.	Adenosine Triphosphate (ATP)
6.	Antioxidants
7.	Sirtuin 1
8.	PPAR gamma
9.	Enzymes
10.	genipin

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Trabeculectomy (Trabeculoplasty)
5.	Resuscitation