Zika Virus Infection

A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.

Also Known As:

Networked: 1286 relevant articles (85 outcomes, 153 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infections
2.	Microcephaly
3.	Zika Virus Infection
4.	Bites and Stings (Sting)
5.	Congenital Abnormalities (Deformity)

Experts

1.	Harris, Eva: 27 articles (01/2022 - 08/2016)
2.	Diamond, Michael S: 21 articles (10/2020 - 01/2016)
3.	Shi, Pei-Yong: 18 articles (01/2021 - 12/2016)
4.	Balmaseda, Angel: 16 articles (10/2021 - 11/2017)
5.	Honein, Margaret A: 15 articles (01/2022 - 01/2016)
6.	Shresta, Sujan: 15 articles (01/2021 - 01/2017)
7.	Qin, Cheng-Feng: 14 articles (01/2022 - 01/2017)
8.	Meaney-Delman, Dana: 12 articles (01/2022 - 07/2016)
9.	Shan, Chao: 12 articles (01/2021 - 01/2017)
10.	Desprès, Philippe: 11 articles (01/2022 - 01/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Zika Virus Infection:

1.	VaccinesIBA 01/01/2020 - "Both SAM (CNE) vaccines protected these animals from ZIKV challenge, with one candidate providing complete protection against ZIKV infection in nonhuman primates. " 01/01/2018 - "These results demonstrate that attenuated rVSV co-expressing prM, E, and NS1 is a promising vaccine candidate for protection against ZIKV infection and highlights an important role for NS1 in ZIKV-specific cellular immune responses." 01/01/2021 - "In summary, these results suggest that baseline DENV immunity induced by vaccination does not significantly enhance ZIKV infection or impair the protective efficacy of candidate ZIKV vaccines in these models. " 01/01/2018 - "It is of significant importance and urgency to develop safe and effective vaccines to prevent ZIKV infection. " 01/01/2018 - "Overall this study identifies a novel role for polyfunctional and polyclonal CD4+T cells in providing protection against ZIKV infection and highlights the need for vaccines to develop robust CD4+T cell responses to prevent ZIKV neuroinvasion and limit replication within the CNS."
2.	Antiviral Agents (Antivirals)IBA 03/29/2022 - "So far, there is no effective remedy for ZIKV infection, mainly due to the limited ability of antiviral drugs to cross blood-placental and/or blood-brain barriers (BPB and BBB, respectively). " 11/02/2019 - "No therapeutic agents have, so far, been approved for the treatment of ZIKV infection in humans; as such, there is a need for a continuous effort to develop effective and safe antiviral drugs to treat ZIKV-caused diseases. " 07/27/2023 - "Our study therefore highlights an important role for the integrated stress response pathway and ATF3 in establishing an antiviral effect during ZIKV infection." 12/07/2022 - "In this study, we characterized the ZIKV infection, evaluated the antiviral profile, and demonstrated the AXL and TIM-1 expression on the PC3 prostate cell line. " 04/01/2022 - "This study used phenotypic screening to identify a series of 1,2,4-oxadiazole derivatives that possess antiviral activity against ZIKV infection. "
3.	Neutralizing AntibodiesIBA 10/26/2022 - "We found no significant difference in neutralizing antibody titer in vaccinated or unvaccinated challenged animals; therefore, it is likely that cellular immunity plays a major role in ZVAX-mediated protection against ZIKV infection. " 01/01/2018 - "In addition, NS1 alone is capable of conferring partial protection against ZIKV infection in mice even though it does not induce neutralizing antibodies. " 01/01/2018 - "Moreover, using a maternal immunization protocol, neutralizing antibodies provided specific passive protection against ZIKV infection in neonatal mice and effectively inhibited the growth delay. " 01/01/2019 - "In this study, we aimed to determine if EDIII is a major target of the potent serum neutralizing antibodies present in people after ZIKV infection. " 01/01/2022 - "A cytotoxic-skewed immune set point predicts low neutralizing antibody levels after Zika virus infection."
4.	Proteins (Proteins, Gene)FDA Link 01/01/2023 - "The transmembrane protein Axl was proposed as an entry receptor for Zika virus (ZIKV) infection in vitro, but conflicting results from in vivo studies have made it difficult to establish Axl as a physiologically relevant ZIKV receptor. " 12/01/2021 - "Our study showed that 4.1R is an important host cell protein during ZIKV infection and may be involved in the process of viral entry into host cells." 01/01/2019 - "In this study, we investigated the formation of stress granules during Zika virus (ZIKV) infection and the role stress granule proteins play during the viral life cycle. " 01/01/2019 - "This study's objective is to identify host cell proteins that are significantly dysregulated during ZIKV infection. " 12/27/2018 - "Results obtained from this study indicate the potential of the Asian-lineage Zika Env-CD4 and Env proteins in ELISA assays to monitor humoral immune responses in upcoming clinical trials as well as a sero-diagnostic tool in ZIKV infection."
5.	AntibodiesIBA 01/01/2019 - "Because suitable quantities of highly potent human polyclonal antibodies can be quickly produced from the TcB system against ZIKV and have demonstrated therapeutic efficacy in a small animal model, they have the potential as an effective countermeasure against ZIKV infection." 11/03/2021 - "We demonstrated that li-linkage enhanced the production of anti-NS1 antibodies and induced an accelerated and prolonged polyfunctional CD8 T cell response in mice, which ultimately resulted in a high degree of protection against ZIKV infection of the CNS." 10/01/2020 - "DSV4-induced antibodies, known to be predominantly type-specific, provided significant protection against lethal DENV challenge, but did not promote ADE of either DENV or ZIKV infection in vivo. " 01/01/2019 - "The high correlation between the presence of ZIKV NS1 antibodies and ZIKV PRNT suggests that immunological protection against ZIKV infection in Thailand arises from prior exposure to ZIKV, and not through cross neutralization." 10/19/2020 - "Anti-NS1 antibodies provide an alternative strategy for protection against congenital ZIKV infection without causing ADE."
6.	AntigensIBA 01/01/2019 - "In seroconversion panels obtained from patients from Brazil, diagnostic testing for Zika virus infection was improved by combining multiple antibody isotypes, techniques, and antigens, but sensitivity remained suboptimal. " 01/01/2021 - "Here, we employed Western blot analysis using antigens of 6 flaviviruses from 3 serocomplexes to investigate antibody responses following reverse transcription-PCR (RT-PCR)-confirmed ZIKV infection. " 12/01/2020 - "The assay had a broad dynamic range (>5 logs) and has the potential to distinguish antigen-specific responses induced by ZIKV infection from cross-reactive responses. " 01/01/2016 - "Specificity of Dengue NS1 Antigen in Differential Diagnosis of Dengue and Zika Virus Infection." 01/01/2016 - "False positive dengue NS1 antigen test in a traveller with an acute Zika virus infection imported into Switzerland."
7.	DNA VaccinesIBA 12/18/2019 - "We tested the efficacy of ZIKV DNA vaccine VRC5283 in a rhesus macaque model of congenital ZIKV infection. " 01/01/2016 - "In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine." 12/01/2019 - "Here, we describe a novel DNA vaccine encoding a secreted ZIKV NS1, that confers rapid protection from systemic ZIKV infection in immunocompetent mice. " 11/01/2016 - "DNA Vaccine Protects Monkeys Against Zika Virus Infection." 01/01/2020 - "Here, we show that recombinant VSV and DNA vaccines expressing NS1, alone, confer partial protection against ZIKV infection in both immunocompetent and immunodeficient mice, highlighting the value of NS1 as a potential vaccine candidate."
8.	RNA (Ribonucleic Acid)IBA 01/01/2018 - "Aim: The aim of this study was to evaluate the efficacy of saliva and urine to diagnose ZIKV infection in subjects during the acute phase, through ZIKV RNA detection by LAMP. " 09/27/2018 - "The prolonged time until ZIKV RNA clearance in serum in this study may have implications for the diagnosis and prevention of ZIKV infection. " 12/01/2017 - "This is the first study evaluating the prevalence of ZIKV RNA among Brazilian blood donors, which was relatively high and might lead to TT-ZIKV infection. " 07/21/2023 - "Leveraging integrative systems biology, proteomics, and RNA-seq, we analyzed embryonic brain tissues from an immunocompetent, wild-type congenital ZIKV infection mouse model. " 01/01/2023 - "Complement activation and its contribution to testicular damage are validated by ELISA, RT‒qPCR and IFA and further verify in ZIKV-infected northern pigtailed macaques by RNA genome sequencing and IFA, suggesting that this might be the common response to ZIKV infection in primates. "
9.	Viral RNAIBA 02/01/2022 - "Within 48 hours after ZIKV infection at embryonic day 10, viral RNA was detected in placentas and fetuses from ZIKA infected dams, which corresponded with placental damage and reduced fetal viability as compared with mock infected dams. " 01/01/2022 - "In this report we showed that exogenously expressed ZIKV NS2A and NS4A inhibited ZIKV infection by inhibiting viral RNA replication in microglial cells and astrocytes. " 07/30/2021 - "Here, it was found that the multimammate mouse and New Zealand White (NZW) rabbits are not susceptible ZIKV infection as determined by a lack viral RNA in tissues and fluids collected. " 01/01/2018 - "Diagnosing ZIKV infection remains a challenge, as viral RNA detection is only applicable until a few days after the onset of symptoms. " 11/09/2016 - "Dynamics of Human and Viral RNA Methylation during Zika Virus Infection."
10.	Interferon LambdaIBA 01/01/2020 - "In this mSphere of Influence article, she reflects on how the papers "Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection" (https://doi.org/10.1016/j.chom.2016.03.008) and "A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance" (https://doi.org/10.1126/sciadv.1501462) by Carolyn Coyne's group have made an impact on her, inspiring her to explore immunity in the placenta by indicating the unique innate immune control elicited at the maternal-fetal barrier as well as by providing physiologically relevant model systems for study." 05/11/2016 - "Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection." 01/01/2017 - "Collectively, these data provide important insights into the defense mechanisms used by syncytiotrophoblasts at various stages of human gestation to resist ZIKV infection and new human models to study the role of type III IFNs in the vertical transmission of ZIKV and other viruses associated with congenital disease." 01/01/2019 - "As such, this raises the question of a potential role for type III IFN during ZIKV infection. " 01/01/2019 - "Interferon lambda protects the female reproductive tract against Zika virus infection."

Therapies and Procedures

1.	Therapeutics 01/01/2020 - "Further characterization of this neonatal nonhuman primate model of gestational Zika virus infection will provide opportunities to evaluate the efficacy of pre- and postnatal therapeutics for gestational Zika virus infection and CZS." 11/30/2022 - "Our studies highlight the underappreciated role FcRn plays in ZIKV infection and may have implications for anti-ZIKV prophylaxis and therapy in pregnant women." 01/01/2022 - "The findings from this study increase our understanding of persistent ZIKV infection which can inform risk of sexual transmission during assisted reproductive therapies as well as potential impacts on male fertility." 10/05/2021 - "In this study, we characterize the IFNβ-mediated anti-viral response in trophoblast cells in order to identify critical components that are necessary for the successful control of viral replication and determine whether components of the IFN-induced response can be used as a replacement therapy for ZIKA virus infection during pregnancy. " 06/01/2021 - "The active compounds identified in this study represent potential therapies for the treatment of ZIKV infection."
2.	Immunotherapy 01/01/2019 - "Our data indicate that antibody-mediated immunotherapy is effective in treating ZIKV infection. " 01/01/2019 - "Our data describe the coexistence of a recent central nervous system (CNS) ZIKV infection accompanied by a severe ADEM-like syndrome outcome in a patient with clinical history of MS. A de novo immune response concomitant with ZIKV infection might be involved in the mechanism of the ADEM-like syndrome and response to immunotherapy. " 03/01/2018 - "Mechanistically, ZIKV infection preferentially counterbalances monocyte and/or NK cell activity, with implications for targeted cytokine immunotherapies. " 02/28/2016 - "Further studies are needed to confirm the suspected association between ZIKV infection and microcephaly; to identify antiviral, immunotherapy, or prophylactic vaccine; to introduce diagnostic ELISA testing. "
3.	Intraperitoneal Injections 01/01/2018 - "More importantly, a single intraperitoneal injection of pregnant mice with a human monoclonal neutralizing antibody provides full protection against ZIKV infection and its associated damages in the developing fetuses. " 01/01/2018 - "A single intraperitoneal injection of these antibodies conveyed distinct levels of adult and in utero protection from ZIKV infection, which closely mirrored their respective in vitro neutralizing activities. "
4.	Intravenous Injections 01/01/2022 - "In vivo antiviral assay indicated that both of them effectively inhibited ZIKV replication in C57BL/6J and IFNα/β receptor-deficient (Ifnar1-/-) mice when CRAMP or LL-37 was intravenously injected in parallel with or at 1 h after intravenous injection of ZIKV, implying that CRAMP and LL-37 effectively inactivated ZIKV particles and exhibited therapeutic potential against ZIKV infection in vivo. "
5.	Blood Transfusion (Blood Transfusions) 01/01/2020 - "The yearly estimation of the risk of transmitting ZIKV infection by blood transfusion remained low through the study period for all locations, with the highest potential risk estimated in Darwin. " 01/01/2022 - "Zika virus disease is caused by a flavivirus transmitted by Aedes spp. Mosquitoes, although other mechanisms such as blood transfusion, sexual and maternal-fetal transmission have been demonstrated. " 07/01/2018 - "To investigate the risk of Zika virus infection after a blood transfusion in an area of Brazil where a possible transmission by a platelet concentrate has been described. " 04/01/2016 - "In addition to the vector-mediated transmission of Zika fever, probable human-to-human transmission through exchange of body fluids, including sexual and perinatal transmission and through blood transfusion, makes containment of this new entity more challenging. " 01/01/2020 - "Although Zika virus (ZIKV) infection is mainly transmitted through mosquito bite, it can also be transmitted through blood transfusion. "