Autophagy-Related Protein 5

An autophagy-related protein that functions in AUTOPHAGOSOME biogenesis. It is conjugated to the ATG12 PROTEIN via a process that is similar to UBIQUITINATION and involves the ATG7 PROTEIN and ATG10 enzyme. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme and is required for the localization of ATG8 PROTEINS to AUTOPHAGOSOME vesicle membranes and modification of membrane lipids.

Also Known As:

Networked: 57 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Nakhoul, Farid: 2 articles (11/2021 - 09/2020)
2.	Nakhoul, Nakhoul: 2 articles (11/2021 - 09/2020)
3.	Fan, Xiude: 2 articles (01/2020 - 05/2019)
4.	Han, Qunying: 2 articles (01/2020 - 05/2019)
5.	Li, Na: 2 articles (01/2020 - 05/2019)
6.	Liu, Zhengwen: 2 articles (01/2020 - 05/2019)
7.	Lv, Yi: 2 articles (01/2020 - 05/2019)
8.	Wang, Xiaoyun: 2 articles (01/2020 - 05/2019)
9.	Zhang, Kun: 2 articles (01/2020 - 05/2019)
10.	Zhang, Xiaoge: 2 articles (01/2020 - 05/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "We investigated the consequences of varying levels of the autophagy related 5 (Atg5) protein on pancreatic tumor formation and progression. " 10/01/2017 - "TUNEL and immunohistochemistry assays showed the increase in apoptotic cells and the decrease in both conversion of LC3B-I to LC3B-II and Atg5 protein expression in the tumor tissues from mice with the combined treatment. " 04/26/2021 - "After stratification with demographic and clinicopathologic factors, a high ATG5 protein level was significantly correlated with unfavorable overall survival in female and elder (>60 year) CRC patients and tumor tissues with poor differentiation, late T stages (III + IV), whereas the ATG5 protein level was positively associated with the overall survival in CRC patients without lymph node invasion and radiation therapy. " 12/01/2021 - "The positive rate of ATG5 protein expression was 23.3% in the normal group, 50.0% in the intraepithelial neoplasia group, and 76.7% in the gastric cancer group. " 01/01/2019 - "Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice."
2.	Hypoxia (Hypoxemia) 10/24/2023 - "The hypoxia-induced autophagy was found to induce the migration and proliferation of fibroblasts, a process that could be reversed by knocking down the autophagy-related gene for autophagy protein 5, ATG5. " 12/01/2022 - "Meanwhile, Mn deficiency enhanced the expression levels of hypoxia-inducible factor-1 α (HIF-1α), autophagy-related protein 5 (ATG5), and microtubule-associated protein 1 light chain 3 β (LC3-II) in TGP, but decreased the expression level of SQSTM1 (P62), which suggested that autophagy was activated during this process. " 01/01/2017 - "We also showed that CyPA was upregulated and acetylated under hypoxia and led to the abnormal occurrence of autophagy through its interaction with autophagy protein 5 and autophagy protein 7. Moreover, acetylated CyPA was essential for the excessive proliferation, migration, and tube formation networks of pulmonary arterial endothelial cells. " 01/01/2015 - "In this study, we show that Autophagy can mediate programmed cell death (PCD) of cancer cells in responding to cobalt chloride (CoCl2)-induced hypoxia in a Beclin-1-independent but autophagy protein 5 (ATG5)-dependent manner. "
3.	Carcinoma (Carcinomatosis) 11/01/2011 - "In the present study, we analyzed ATG5 protein expression in 107 prostate carcinomas by immunohistochemistry; additionally, we assayed the presence of ATG5 somatic mutations in 45 prostate carcinomas by single-strand conformation polymorphism. " 07/15/2011 - "Immunohistochemically, ATG5 protein was well expressed in normal stomach, colon, and liver epithelial cells, while it was lost in 21 (21%) of the gastric carcinomas, in 22 (23%) of the colorectal carcinomas, and in 5 (10%) of the hepatocellular carcinomas. "
4.	Asthma (Bronchial Asthma) 01/01/2017 - "No association was detected between ATG5 protein expression and asthma per se, severity, and lung function. " 08/29/2023 - "Autophagy protein 5 (ATG5) regulates airway epithelial cell autophagy, immune response, and inflammation, which is involved in asthma progression. " 08/29/2023 - "Serum autophagy protein 5 is positively related to T helper 2/T helper 1 ratio, inflammation, and exacerbation in adult asthma patients." 01/01/2017 - "This study aimed to determine if (1) collagen deposition in asthmatic airways is associated with ATG5 expression and (2) ATG5 protein expression is associated with asthma per se and severity. "
5.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/01/2023 - "The purpose of the study was to investigate the effect of isoflurane postconditioning on neuron injury in MCAO (middle cerebral artery occlusion) rats and its molecular mechanism of affecting autophagy through miR-384-5p/ATG5 (autophagy-related protein 5). "

Related Drugs and Biologics

1.	Isoflurane
2.	Collagen
3.	cobaltous chloride (cobalt(II)chloride)
4.	Proteins (Proteins, Gene)
5.	Beclin-1
6.	AMP-Activated Protein Kinases
7.	Biomarkers (Surrogate Marker)
8.	Phosphotransferases (Kinase)
9.	Phosphatidylinositols (Phosphatidylinositol)
10.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)

Related Therapies and Procedures

1.	Radiotherapy