CD48 Antigen

A 40-45 KDa GPI-linked protein in the SLAM family that consists of two IMMUNOGLOBULIN C2-SET DOMAINS. It is expressed on the surface of a variety of cells with immune functions, including THYMOCYTES; mature B-LYMPHOCYTES and T-LYMPHOCYTES; NATURAL KILLER CELLS; DENDRITIC CELLS; MAST CELLS; and EOSINOPHILS. It binds to CD2 and 2B4 (CD244) receptors to activate and modulate the immunologic response.

Also Known As:

B-Lymphocyte Activation Marker BLAST-1; BCM1 Surface Antigen; Blast1 Antigen; Leukocyte Antigen MEM-102; MRC OX-45 Antigen; P41 Antigen; SLAM Family Member 2; SLAMF2 Protein; Signal-Transducing Glycoprotein-60; Signaling Lymphocytic Activation Molecule 2; Signaling Lymphocytic Activation Molecule Family Member 2; Antigen, CD48; Antigen, MRC OX-45; Antigen, P41; B Lymphocyte Activation Marker BLAST 1; Glycoprotein-60, Signal-Transducing; Leukocyte Antigen MEM 102; MEM-102, Leukocyte Antigen; MRC OX 45 Antigen; Signal Transducing Glycoprotein 60; Surface Antigen, BCM1

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Chronic Fatigue Syndrome (Myalgic Encephalomyelitis) 11/01/1995 - "To evaluate the association between human herpesvirus 6 (HHV-6) and chronic fatigue syndrome (CFS), 2 geographically separate groups of CFS patients (125 and 29 patients, respectively) and healthy controls (150 and 15 controls, respectively) were compared, using an EIA, for antibodies to HHV-6 early antigen p41/38 (EA). " 11/01/1995 - "Prevalence of IgM antibodies to human herpesvirus 6 early antigen (p41/38) in patients with chronic fatigue syndrome."
2.	HIV Infections (HIV Infection) 05/02/1986 - "Serum antibody to p41 antigen of HTLV-III and/or direct evidence of HTLV-III in lymphocytes was considered indicative of HTLV-III/LAV infection. "
3.	Malaria 05/20/1988 - "Immunization with a 41-kilodalton blood stage antigen (p41) of Plasmodium falciparum induces immunity to malaria in monkeys. "
4.	Hodgkin Disease (Hodgkin's Disease) 09/01/1998 - "Of interest, the expression of the early p41 antigen was detected in the so-called "mummified" Reed-Sternberg cells, in two Hodgkin's disease cases. "
5.	Autoimmune Diseases (Autoimmune Disease) 12/01/1997 - "In order to extend these observations, we have demonstrated increased IgM serum antibody responses to HHV-6 early antigen (p41/38) in patients with relapsing-remitting MS (RRMS), compared with patients with chronic progressive MS (CPMS), patients with other neurologic disease (OND), patients with other autoimmune disease (OID), and normal controls. "

Related Drugs and Biologics

1.	Immunoglobulin M (IgM)
2.	Antibodies
3.	4-chlorophenyl methyl sulfide (CPMS)