Trefoil Factor-3

A 59 amino acid (6.6 kDa) trefoil factor that contains a single trefoil domain. It is expressed in all tissues with MUCOUS MEMBRANES, including GOBLET CELLS of the SMALL INTESTINE and LARGE INTESTINE. It associates with MUCIN-2 in the small intestine and may regulate epithelial CELL MIGRATION and WOUND HEALING.

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Networked: 250 relevant articles (11 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lobie, Peter E: 12 articles (03/2022 - 12/2010)
2.	Pandey, Vijay: 10 articles (03/2022 - 09/2014)
3.	Zhu, Tao: 10 articles (03/2022 - 12/2010)
4.	Peng, Xi: 7 articles (07/2020 - 07/2008)
5.	Ma, Lan: 6 articles (12/2019 - 06/2017)
6.	Sun, Mei: 6 articles (12/2019 - 04/2005)
7.	Wu, Zheng-Sheng: 6 articles (11/2019 - 09/2014)
8.	Takano, Toru: 6 articles (02/2012 - 01/2004)
9.	Wu, Dan: 5 articles (07/2020 - 10/2011)
10.	Chong, Qing-Yun: 5 articles (12/2019 - 06/2017)

Related Diseases

1.	Colitis 01/01/2005 - "In order to investigate the protective effects of intestinal trefoil factor (ITF) on colonic mucosa in experimental colitis of rats, ITF was detected by RT-PCR and immunohistochemistry at different time points. " 01/01/2005 - "Effects of intestinal trefoil, factor on colonic mucosa in experimental colitis of rats." 10/01/2004 - "Furthermore, colons with constitutive activation of HIF displayed increased expression levels of HIF-1-regulated barrier-protective genes (multidrug resistance gene-1, intestinal trefoil factor, CD73), resulting in attenuated loss of barrier during colitis in vivo. " 05/01/1999 - "In addition, endogenous concentrations of rat TFF2 and TFF3 (intestinal trefoil factor) were increased in the active phase of colitis and were reduced to basal levels by hTFF2 treatment. " 05/10/2022 - "Trefoil Factor 3 accumulates in the intestinal cavity of the colon in the state of colitis, which may increase the adhesion of Painong San particles. "
2.	Wounds and Injuries (Trauma) 07/01/2010 - "Trefoil factor 3 (TFF3) is involved in both protecting the intestinal epithelium against injury as well as aiding in wound repair following injury. " 05/09/2008 - "Intestinal trefoil factor/TFF3 promotes re-epithelialization of corneal wounds." 01/18/2000 - "Intestinal trefoil factor (ITF) is an essential regulator of colonic epithelial restitution, the rapid migration of colonocytes over mucosal wounds. " 03/01/2004 - "Intestinal trefoil factor improved intestinal epithelial cell viability and wound repair after chemotherapy exposure in vitro. " 10/01/2006 - "[Protective effects of recombinant intestinal trefoil factor against intestinal injuries induced by endotoxin in young rats]."
3.	Mucositis 03/01/2004 - "These studies suggest that intestinal trefoil factor is involved in protection against and recovery from intestinal mucositis induced by radiation and chemotherapy." 03/01/2004 - "Intestinal trefoil factor-deficient mice (intestinal trefoil factor(-/-)) were more susceptible to chemotherapy- and radiation-induced mucositis. " 03/01/2004 - "Oral recombinant intestinal trefoil factor reduced the severity of both chemotherapy-induced and chemotherapy/radiotherapy-induced intestinal mucositis. " 10/01/2009 - "Intestinal trefoil factor (ITF), a member of trefoil factor family (TFF) domain peptides, was proved to be very effective in prevention and healing of acute dextran sodium sulfate-induced colitis, and was also involved in protection against and recovery from intestinal mucositis induced by radiation and chemotherapy. "
4.	Necrotizing Enterocolitis 01/01/2014 - "Recombinant human trefoil factor 3 ameliorates bowel injury: its anti-inflammatory effect on experimental necrotizing enterocolitis." 01/01/2007 - "Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model." 01/01/2007 - "Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model." 11/15/2003 - "The aim of this study was to determine the effect of recombinant human trefoil factor 3 (rhTFF3) on hypoxia-induced necrotizing enterocolitis (NEC) in immature rats. " 11/15/2003 - "The therapeutic effect of recombinant human trefoil factor 3 on hypoxia-induced necrotizing enterocolitis in immature rat."
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 08/01/2017 - "Trefoil factor 3 (TFF3) serves an important role in intestinal mucosal damage and healing, and contributes to the pathogenesis and treatment of inflammatory bowel disease (IBD). " 01/01/2013 - "A variant form of the human deleted in malignant brain tumor 1 (DMBT1) gene shows increased expression in inflammatory bowel diseases and interacts with dimeric trefoil factor 3 (TFF3)." 12/01/2019 - "This study aimed to explore the expression and correlation of microRNA-7 (miR-7) and trefoil factor 3 (TFF3) genes and proteins in inflammatory bowel disease (IBD) mouse models and to elucidate the effect of miR-7 inhibition in the intestinal mucosa in IBD models. " 01/01/2019 - "In this study, we aimed to evaluate the role of serum trefoil factor 3 (TFF3) as a biomarker of disease activity in patients with inflammatory bowel disease (IBD) and to compare TFF3 values with those of fecal calprotectin (FC). " 01/01/2002 - "Down-regulation of intestinal trefoil factor TFF3 due to transcriptional repression by IL1beta through NF-kappaB as well as by IL6 through C/EBPbeta activation in vitro may reflect the situation in vivo and may contribute to ulceration and decreased wound healing during inflammatory bowel disease. "

Related Drugs and Biologics

1.	Trefoil Factor-3
2.	Proteins (Proteins, Gene)
3.	Trefoil Factors
4.	Peptides (Polypeptides)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Calbindins
7.	Interleukin-1beta (Interleukin 1 beta)
8.	Amine Oxidase (Copper-Containing)
9.	Cisplatin (Platino)
10.	Oral Sprays

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Neoadjuvant Therapy
4.	Enema (Enemas)
5.	Electronic Nose