Trefoil Factor-1

A 60 amino acid (6.5 kDa) trefoil factor that contains a single trefoil domain. It is expressed primarily by surface EPITHELIAL CELLS of the GASTRIC MUCOSA, where it associates with MUCIN 5AC.

Also Known As:

Networked: 207 relevant articles (3 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Zheng: 4 articles (10/2019 - 07/2015)
2.	Soutto, Mohammed: 4 articles (10/2019 - 07/2015)
3.	Davie, James R: 4 articles (01/2013 - 01/2005)
4.	Rio, Marie-Christine: 4 articles (09/2012 - 05/2002)
5.	Wang, Lin: 4 articles (12/2008 - 05/2005)
6.	Eletto, Daniela: 3 articles (02/2021 - 01/2017)
7.	Porta, Amalia: 3 articles (02/2021 - 01/2017)
8.	Tosco, Alessandra: 3 articles (02/2021 - 01/2017)
9.	Vllahu, Megi: 3 articles (02/2021 - 01/2017)
10.	Belkhiri, Abbes: 3 articles (10/2019 - 07/2015)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 12/01/1997 - "To study the relationship between the expression of PS2 protein and prognosis in the invasive breast cancer (IBC). " 12/01/1997 - "[Study on the relationship between PS2 protein expression and prognosis in invasive breast carcinoma]." 07/21/2011 - "Although trefoil factor 1 (TFF1; previously named pS2) is abnormally expressed in about 50% of human breast tumors, its physiopathological role in this disease has been poorly studied. " 02/01/2002 - "[Analysis of the cytosolic content of the pS2 protein in breast cancer]." 01/01/1999 - "Expression of the oestrogen responsive protein pS2 in human breast cancer."
2.	Fibroma (Fibromatosis) 02/01/2000 - "To predict if antiestrogenic agents are useful in the treatment of breast fibromatoses, we undertook an immunohistochemical study of sex steroid hormone receptors (estrogen receptor, progesterone receptor, and androgen receptor) and protein pS2 in 33 cases. "
3.	Stomach Ulcer (Gastric Ulcer) 06/12/2012 - "The evaluation of expression profiles of TFF1 protein and PGs is helpful for the differentiation of benign gastric ulcer from malignant ulcerocancer." 06/12/2012 - "The expression of TFF1 protein increases in gastric ulcer but decreases in gastric ulcerocancer. " 06/12/2012 - "The TFF1 protein expression was evaluated by immunohistochemistry in biopsies of gastric mucosa from 18 normal controls, 25 patients with gastric ulcer and 13 patients with ulcerative gastric cancer at our hospital during January to June 2011. " 06/12/2012 - "[Expression and significance of trefoil factor 1 protein and serum pepsinogen in benign and malignant gastric ulcers]." 06/12/2012 - "To explore the clinical significance of trefoil factor 1 (TFF1) protein expression and serum pepsinogen (PG) concentration in benign and malignant gastric ulcers. "
4.	Carcinoma (Carcinomatosis) 11/15/2003 - "As loss of trefoil factor 1 (TFF1) expression leads to neoplastic growth in the antropyloric mucosa of mice, the authors sought to comprehensively study the human TFF1 gene in primary gastric carcinomas. " 09/01/2015 - "Evaluating the utility of trefoil factor 1 as a mammary-specific immunostain compared and in conjunction with GATA-3 and mammaglobin in the distinction between carcinoma of breast and lung." 10/01/2009 - "Furthermore, neutralization of secreted TFF1 protein by polyclonal antibody decreased mammary carcinoma cell viability in vitro and resulted in regression of mammary carcinoma xenografts. " 10/01/2009 - "The functional role of autocrine trefoil factor-1 (TFF1) in mammary carcinoma has not been previously elucidated. " 10/01/2009 - "Trefoil factor-1 (TFF1) enhances oncogenicity of mammary carcinoma cells."
5.	Carcinogenesis 12/01/2008 - "Amplification and invasiveness of epithelial progenitors during gastric carcinogenesis in trefoil factor 1 knockout mice." 12/01/2020 - "Trefoil factor 1 and gastrokine 2 inhibit Helicobacter pylori-induced proliferation and inflammation in gastric cardia and distal carcinogenesis." 12/15/2015 - "Trefoil factor 1 expression suppresses Helicobacter pylori-induced inflammation in gastric carcinogenesis." 09/01/2012 - "To investigate the role of Cox-2 in gastric carcinogenesis in vivo, we utilized trefoil factor 1 (Tff1) deficient mice, which model the neoplastic process of the stomach by developing gastric adenomas with full penetrance. " 04/01/1998 - "Although the function of TFF1 protein in the carcinogenesis of MTC remains to be elucidated, its expression in the majority of cases of both sporadic and hereditary tumours, metastatic tumours, and in C-cell hyperplasia suggests that it may contribute to the pathogenesis of MTC."

Related Drugs and Biologics

1.	Estrogen Receptors
2.	Hormones (Hormone)
3.	Progesterone Receptors (Progesterone Receptor)
4.	Gonadal Steroid Hormones (Sex Hormones)
5.	Androgen Receptors (Androgen Receptor)
6.	Estrogens (Estrogen)
7.	Proteins (Proteins, Gene)
8.	Cathepsin D
9.	Paraffin
10.	Epidermal Growth Factor (EGF)

Related Therapies and Procedures

1.	Therapeutics
2.	Gastrectomy
3.	Drug Therapy (Chemotherapy)